Association between ultrasound findings and serum levels of vascular endothelial growth factor in ampullary pregnancy

Cabar, Fábio Roberto; Pereira, Pedro Paulo; Schultz, Regina; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo

doi:10.1016/j.fertnstert.2014.12.100

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Similar percentages were reported by Cabar et al 15 (27.6%, 28.6% and 43.8%, respectively). The predominance of cases in which trophoblastic invasion reached at least the muscle layer (76.5%) is consistent with previous studies 15,17,20.…”

Section: Discussionsupporting

confidence: 92%

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Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Cabar¹,

Teshima²,

Pereira³

et al. 2016

Clinics

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OBJECTIVE:To evaluate the association between the depth of trophoblastic infiltration and serum vascular endothelial growth factorconcentration in patients with an ampullary pregnancy.METHODS:This prospective cross-sectionalstudy involved 34 patients with an ampullary ectopic pregnancy who underwent salpingectomy between 2012 and 2013. Maternal serum vascular endothelial growth factor concentrations were measured using Luminex technology. Trophoblastic invasion was classified histologically as follows: stage I, limited to the tubal mucosa; stage II, reaching the muscle layer; and stage III,involving the full thickness. The qualitative data were compared using Fisher's exact test. The nonparametric Kruskal-Wallis and Mann-Whitney tests were used to evaluate differences in serum vascular endothelial growth factor among the degrees of trophoblastic invasion. ROC curves were constructed to determine vascular endothelial growth factor cut-off values that predict the degree of tubal invasion based on the best sensitivity and specificity.RESULTS:Eight patients had stage I trophoblastic invasion, seven had stage II, and 19 had stage III. The median serum vascular endothelial growth factorconcentration was 69.88 pg/mL for stage I, 14.53 pg/mL for stage II and 9.08 pg/mL for stage III, with a significant difference between stages I and III. Based on the ROC curve, a serum vascular endothelial growth factor concentration of 25.9 pg/mL best differentiated stage I from stages II and III with asensitivity of 75.0%, specificity of 76.9%, and area under the curve of 0.798.CONCLUSIONS:The depth of trophoblastic penetration into the tubal wall isassociated with serum vascular endothelial growth factor concentration in ampullary pregnancies.

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Section: Discussionsupporting

confidence: 92%

“…These authors concluded that higher serum VEGF levels are related to the discovery of an embryo with a heartbeat by ultrasound. Higher VEGF production is likely to create developmental conditions that are more favorable for ectopic embryos 20.…”

Section: Introductionmentioning

confidence: 99%

Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Cabar¹,

Teshima²,

Pereira³

et al. 2016

Clinics

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“…22 Cabar et al, attempted to correlate the levels of serum vascular endothelial growth factor (VEGF) and ultrasonographic features in EP and concluded that serum VEGF was raised in ectopic pregnancies with cardiac activity. 23 Future studies are required to assess clinical utility of these markers.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of ectopic pregnancies in a tertiary care center: a two-year retrospective study

Airao

Vyas

2022

Int J Reprod Contracept Obstet Gynecol

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Background: Ectopic pregnancy is defined as the implantation and development of blastocyst at a site other than the endometrial lining of the uterine cavity. With its incidence rising, there have been advances in its early diagnosis by Transvaginal sonography, B-Hcg assays and availability of medical and surgical management, thereby reducing mortality and morbidities.Methods: 100 cases were reported in a span of 2 years. Incidence, causes, diagnosis, past history of infertility treatment, tubal ligation, B-Hcg level, hemoglobin level, USG findings were reviewed and the cases were managed accordingly.Results: Incidence was 1/170 pregnancies and was highest between 25-30 years of age; more common in multigravida than primigravida; lower abdominal pain being the most common presenting complain followed by bleeding per vaginum. Etiology-idiopathic>previous abortion>pelvic infection>infertility treatment>previous ectopic>previous pelvic surgeries. Tubal ectopic being the most common followed by cornual>ovarian>rudimentary horn>scar ectopic>abdominal ectopic. More than 2/3rd cases were ruptured ectopics yet most patients were vitally stable at the time of presentation and immediate laprotomy followed by salpingectomy was the preferred modality. Patients who were hemodynamically stable, had Gsac size <4 cm by TVS, B-hcg levels <10,000 U/ml and no free fluid in the pelvic cavity, were managed medically. Most patients required blood transfusion, other than that there was trivial morbidity and no mortality.Conclusions: Most patients being vitally stable on presentation so timely diagnosis and management could prevent mortality and reduce the morbidities to a great extent.

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“…They concluded that serum PGF was undetectable in women with tubal ectopic pregnancies compared to viable intra uterine pregnancies [15] . Cabar et al, correlated the levels of serum vascular endothelial growth factor(VEGF) and ultrasound findings in EP and concluded that serum VEGF was raised in EP with cardiac activity [16] . Further studies are required to evaluate the clinical utility of these markers…”

Section: 7%mentioning

confidence: 99%

Clinical study of ectopic pregnancy

Siripurapu

2020

PIMR

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Background: Ectopic pregnancy is not an uncommon condition and is potentially a life- threatening emergency. There is a rising trend in incidence which necessitates the gynecologists to have comprehensive knowledge about the disease. Aim of the study: To determine the incidence, risk factors, clinical features and management. Materials and method: This study is conducted in Department of Obstetrics and Gynecology of PIMS, Karimnagar. It is a retrospective descriptive study on patients who presented to our department with clinical features of ectopic pregnancy and later confirmed with intraoperative findings or ultrasound, in the 3-year period from January 2017 to January 2020. Result: A Total of 34 patients were diagnosed to have ectopic pregnancy with an incidence of 1in 114 deliveries. The cause of ectopic pregnancy was dilatation and curettage in 11.8% and PID, infertility, prior tubal surgery, previous abortions and OCP usage each contributes by 5.9%. Surgical treatment with salpingectomy was done in majority of the cases and medical management in 3 patients. Blood transfusions were given in 38.2% of cases. Postoperative period is uneventful in all the cases. Conclusion: Gynecologists should have comprehensive knowledge about the clinical presentation and risk factors of EP. If suspected clinically, encouraging women to undergo early ultrasonography allows early detection of EP and can be managed medically or fertility sparing surgical procedures

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Association between ultrasound findings and serum levels of vascular endothelial growth factor in ampullary pregnancy

Cited by 6 publications

References 28 publications

Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Clinical analysis of ectopic pregnancies in a tertiary care center: a two-year retrospective study

Clinical study of ectopic pregnancy

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