Association between urinary propylene oxide metabolite and the risk of dyslexia

Liu, Qi; Wan, Yanjian; Zhu, Bing; Xie, Xinyan; Zhu, Kaiheng; Jiang, Qi; Feng, Yanan; Xiao, Pei; Xiang, Zhen; Wu, Xiaoqian; Zhang, Jiajia; Meng, Heng; Song, Ranran

doi:10.1016/j.envpol.2021.118469

Cited by 14 publications

(6 citation statements)

References 52 publications

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“…Our study shows high levels of PO in exhaled air concentrations in a subset of environmentally sensitive individuals likely having less efficient enzymes unable to detoxify the compound or altered mechanisms of absorption, delaying release of this pollutant or byproduct of other pollutants such as Propene. Our results are in line with other studies that identified byproducts of PO in blood and urine [25,26], showing that exposure to this pollutant is higher than previously thought. Our study aligns with Filser's work also showing that individual metabolism makes a big difference.…”

Section: Propylene Oxide In Exhaled Breathsupporting

confidence: 93%

“…Urinary metabolites of propylene oxide were associated with lower lung function independently of smoking (Liu et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

“…As of 2014, propylene oxide has been reevaluated as a potential biomarker for breast cancer (Turner et al 2023, Garcia et al 2015). Recent research, exemplified by papers such as (Pal & Kannan, 2023, Li et al, 2023, Mendy et al 2022, and Liu et al, 2022), has consistently illuminated the implications of propylene oxide exposures in both humans and animals. These studies indicate associations with various health aspects, including pregnancy and IVF treatment, reduced lung function, oxidative stress, cancer, diabetes, and neurological conditions like dyslexia, highlighting that the broader population’s exposure to propylene oxide is indeed a public health concern.…”

Section: Resultsmentioning

confidence: 99%

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Biological Factors Influencing Individual Responses to Propylene Oxide: A Systematic Review of Exogenous Exposure, Endogenous Production and Detoxification

Gabashvili

2024

Preprint

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Objective: This systematic review aims to synthesize current knowledge on Propylene Oxide (PO) in human exhaled breath, examining its presence across various biological matrices and exploring methodologies for its analysis. It seeks to elucidate the sources of PO in the human body and understand individual variability in detoxification processes. Methods: A comprehensive literature search was conducted across 12 databases and specialized repositories, spanning over 10,000 publications without language restrictions until February 2024. Sixteen AI tools were employed to enhance study identification and analysis, focusing on both direct mentions and indirect evidence of PO behavior and detection in the human body. Assessment tools for risk of bias included SYRCLE's tool for animal studies, the Newcastle-Ottawa Scale for cohort and case-control studies, and the ROBINS-I tool for non-randomized studies. The selection process yielded 88 studies, encompassing a range of research types and species, supplemented by reviews, monographs, and editorials to provide a comprehensive overview. Results: he search revealed limited direct evidence on PO concentrations in exhaled breath, with only one reference providing concrete data (0.083 ppb to 0.3 ppb). However, numerous references offered indirect insights into PO's persistence and detection in the human body, particularly in blood and urine. The review highlights the enzymes involved in PO metabolism, the evolution of analytical methodologies, and the challenges and potentials of employing AI tools in systematic reviews. Conclusions: The scarcity of direct evidence on PO in exhaled breath underscores a significant gap in the literature and indicates variability in environmental compound concentrations influenced by genetics, health status, metabolism, and the microbiome. The review emphasizes the difficulties in synthesizing data on PO effects due to heterogeneous inputs and complex exposure scenarios. It underscores the need for advanced AI capabilities in literature reviews to capture nuanced, indirect evidence more effectively and calls for targeted research and technological innovation in environmental health sciences. This study advocates for the strategic enhancement of AI tools to navigate scientific literature with greater efficacy, leveraging PRISMA guidelines and diverse data sources to minimize bias and enhance reliability.

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Section: Propylene Oxide In Exhaled Breathsupporting

confidence: 93%

“…Urinary metabolites of propylene oxide were associated with lower lung function independently of smoking (Liu et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Biological Factors Influencing Individual Responses to Propylene Oxide: A Systematic Review of Exogenous Exposure, Endogenous Production and Detoxification

Gabashvili

2024

Preprint

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“…No mundo, há uma estimativa de 17,5% de prevalência da dislexia na população infantil mundial (LIU et al, 2022). Já na fase adulta, a cerca de 4% de indivíduos disléxicos (SORIANO-FERRER; PIEDRA MARTÍNEZ, 2017).…”

Section: Humanas E Sociaisunclassified

Neuropsicologia E Psicologia Positiva: Saberes Que Contribuem Para a Compreensão Da Dislexia Na Educação

Dantas Pereira,

Pereira da Silva

2023

ICHS

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O presente artigo se propôs a apresentar como os saberes da neuropsicologia e da psicologia positiva se entrecruzam para a compreensão da dislexia no contexto da educação. Para tanto, o percurso metodológico escolhido no preparo deste texto foi o formato de uma revisão narrativa. Para tanto, foi realizado um levantamento bibliográfico em publicações acadêmicas de circulação nacional e internacional referente ao objeto deste estudo. Esse levantamento foi conduzido através de artigos científicos, livros, páginas eletrônicas, legislações e documentos oficiais. Posto isso, este trabalho foi organizado em duas seções: 1) Breves notas sobre dislexia no contexto educacional; e 2) Contribuições da neuropsicologia e da psicologia positiva para a compreensão da dislexia no campo da educação. Evidenciou-se que a neuropsicologia contribui para a avaliação diagnóstica e reabilitação da dislexia, enquanto, a Psicologia Positiva visa promover o desenvolvimento de habilidades mentais que mudariam a visão da vida do disléxico de modo positivo. Portanto, essas duas áreas da Psicologia devem ser pensadas considerando a subjetividade dos disléxicos e se estão inseridos em escolas ou universidades para resultados mais positivos.

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“…N‐acetyl‐L‐cysteine (NAC) is a mucolytic agent (Liu et al., 2022). Due to its sulfhydryl group, NAC has been demonstrated to possess potent antioxidant and anti‐inflammatory properties in both experimental and clinical studies (Gençosman et al., 2022; Sehirli et al., 2020; Sener et al., 2003; Uzun et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy

Şehirli,

Aksoy,

Sibai

et al. 2023

Int Endodontic J

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AimThis study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases.MethodologyFourty‐eight Wistar albino rats were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1st mandibular molar tooth), (4) AP + ADR Group, (5) AP + NAC group (150 mg/kg/day ip), and (6) AP + ADR + NAC group. After 3 weeks, the rats were decapitated and blood and tissue samples (heart, kidney, and jaw) were collected. Tissue samples were evaluated by biochemical (inflammatory cytokines and hemodynamic parameters) and radiological analyses. One‐way anova with Tukey post hoc tests was used to compare data, considering p < .05 as statistically significant.ResultsThe serum levels of TNF‐α, IL‐1β, BUN, Creatinine, CK, and LDH were elevated in the test groups compared with the control group, and treatment with NAC reduced these levels (p < .05). Heart and kidney tissue analysis showed a higher heart‐to‐body weight ratio (HW/BW) and kidney‐to‐body weight ratio (KW/BW) in the test groups compared with the control group (p < .05). No significant differences in HW/BW and KW/BW were found between the control and AP + NAC groups. Volumetric apical bone resorption analysis showed an increase in periapical radiolucencies in AP‐induced groups indicating apical periodontitis. NAC treatment reduced the total area and volume of resorption cavities (p < .05).ConclusionsThe results suggest that NAC's antioxidant and anti‐inflammatory effects can reduce adriamycin‐mediated heart and kidney damage and may have a positive effect on apical periodontitis in individuals with nephropathy and cardiomyopathy.

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Association between urinary propylene oxide metabolite and the risk of dyslexia

Cited by 14 publications

References 52 publications

Biological Factors Influencing Individual Responses to Propylene Oxide: A Systematic Review of Exogenous Exposure, Endogenous Production and Detoxification

Biological Factors Influencing Individual Responses to Propylene Oxide: A Systematic Review of Exogenous Exposure, Endogenous Production and Detoxification

Neuropsicologia E Psicologia Positiva: Saberes Que Contribuem Para a Compreensão Da Dislexia Na Educação

Effects of N‐acetyl‐L‐cysteine against apical periodontitis in rats with adriamycin‐induced cardiomyopathy and nephropathy

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