Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study

Okada, Hiroshi; Hamaguchi, Masahide; Habu, Momoko; Kurogi, Kazushiro; Murata, Hiroaki; Ito, Masato; Fukui, Michiaki

doi:10.1136/bmjdrc-2021-002123

Cited by 11 publications

(7 citation statements)

References 21 publications

(25 reference statements)

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“…Panasonic cohort study revealed that risk of developing type 2 diabetes mellitus increased 11.1% with 1% increase in coefficient of variation in BMI. 17 Our findings were consistent with these prior studies that higher BMI was associated with more co-morbidities such as hypertension and type 2 diabetes mellitus.…”

Section: Discussionsupporting

confidence: 93%

“…They found out that when BMI increased 3 kg/m 2 , there is higher risk of hypertension by 65% in men and 83% in women compared to those with stable BMI. Panasonic cohort study revealed that risk of developing type 2 diabetes mellitus increased 11.1% with 1% increase in coefficient of variation in BMI 17 . Our findings were consistent with these prior studies that higher BMI was associated with more co‐morbidities such as hypertension and type 2 diabetes mellitus.…”

Section: Discussionsupporting

confidence: 92%

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Obesity paradox in patients with chronic total occlusion of coronary artery

Tsai

Huang

et al. 2021

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Obesity paradox in patients with chronic total occlusion of coronary artery

Tsai

Huang

et al. 2021

Eur J Clin Investigation

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“…This study used the database of the Panasonic cohort study from 2008 to 2018. The Panasonic cohort study is described in detail elsewhere 14 . All participants received a blood examination every year.…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

Fasting plasma glucose level in the range of 90–99 mg/dL and the risk of the onset of type 2 diabetes: Population‐based Panasonic cohort study 2

Munekawa

Okada

Hamaguchi

et al. 2021

J of Diabetes Invest

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Aim/Introduction As the association between a fasting glucose concentration of 90–99 mg/dL and the onset of type 2 diabetes is still controversial, we aimed to assess it in 37,148 Japanese individuals with a normal plasma glucose concentration. Materials and Methods This long‐term retrospective cohort study included individuals having a medical checkup at Panasonic Corporation from 2008 to 2018. In total, 1,028 participants developed type 2 diabetes. Results Cox regression analyses revealed that the risk for the onset of diabetes increased by 9.0% per 1 mg/dL increase in fasting plasma glucose concentration in subjects with the concentration ranging from 90 to 99 mg/dL. Compared with individuals with a fasting glucose concentration of ≤89 mg/dL, the adjusted hazard ratios for developing diabetes were 1.53 (95% CI; 1.22–1.91), 1.76 (95% CI; 1.41–2.18), 1.89 (95% CI; 1.52–2.35), 3.17 (95% CI; 2.61–3.84), and 3.41 (95% CI; 2.79–4.15) at fasting plasma glucose concentrations of 90–91, 92–93, 94–95, 96–97, and 98–99 mg/dL, respectively. In populations with obesity, the adjusted hazards ratios for developing diabetes were 1.56 (95% CI; 1.15–2.09), 1.82 (95% CI; 1.37–2.40), 2.05 (95% CI; 1.55–2.69), 3.53 (95% CI; 2.79–4.46), and 3.28 (95% CI; 2.53–4.22) at fasting plasma glucose concentrations of 90–91, 92–93, 94–95, 96–97, and 98–99 mg/dL, respectively. Conclusions This study demonstrates that the risk of type 2 diabetes among subjects having a fasting plasma glucose concentration of 90–99 mg/dL, is progressively higher with an increasing level of fasting plasma glucose concentration in a Japanese people.

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“…Several previous studies have examined the relationship between the consequence of variabilities in obesity measures on health outcomes in participants with or without diabetes but the results are inconsistent. Some studies have found variability in BMI to be associated with the development of diabetes [ 29 ], increased risk of new-onset atrial fibrillation and myocardial infarction [ 30 ], increased rate of hospitalization from heart failure [ 31 ], whiles WC variability has also been found to be associated with risk of stroke and all-cause mortality [ 28 ]. However, these studies did not assess the relationship between obesity variability and diabetic microvascular complications.…”

Section: Discussionmentioning

confidence: 99%

“…However, it has been suggested that a subsequent increase in weight after an initial decrease may be associated with a more rapid adipose tissue growth and hyperplasia due to metabolic shifts which favor lipid storage [ 15 ]. Since adipose tissue is a highly active metabolic endocrine organ [ 34 ], the rapid remodelling of adipose tissue linked to high obesity variability may provoke abnormal production of proinflammatory adipokines, which may potentially lead to adverse health outcomes including diabetes and its associated complications [ 15 , 17 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial

Hukportie¹,

Li²,

Zhou³

et al. 2022

Diabetes Metab J

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Background: Obesity is associated with adverse health events among diabetic patients, however, the relationship between obesity fluctuation and risk of microvascular complications among this specific population is unclear. We aimed to examine the effect of waist circumference (WC) and body mass index (BMI) variability on the risk of diabetic microvascular outcomeMethods: Annually recorded anthropometric data in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was used to examine the association of WC and BMI variability defined as variability independent of mean, with the risk of microvascular outcomes, including neuropathy, nephropathy, and retinopathy. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) (Trial registration: ClinicalTrials.gov., no. NCT00000620).Results: There were 4,031, 5,369, and 2,601 cases of neuropathy, nephropathy, and retinopathy during a follow-up period of 22,524, 23,941, and 23,850 person-years, respectively. Higher levels of WC and BMI variability were associated with an increased risk of neuropathy. Compared with the lowest quartile, the fully-adjusted HR (95% CI) for the highest quartile of WC and BMI variability for neuropathy risk were 1.21 (1.05 to 1.40) and 1.16 (1.00 to 1.33), respectively. Also, higher quartiles of BMI variability but not WC variability were associated with increased risk of nephropathic events. The fully-adjusted HR (95% CI) for the highest quartile compared with the lowest quartile of BMI variability was 1.31 (1.18 to 1.46). However, the results for retinopathic events were all insignificant.Conclusion: Among participants with type 2 diabetes mellitus, WC and BMI variability were associated with a higher risk of neuropathic events, whereas BMI variability was associated with an increased risk of nephropathic events.

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Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study

Cited by 11 publications

References 21 publications

Obesity paradox in patients with chronic total occlusion of coronary artery

Obesity paradox in patients with chronic total occlusion of coronary artery

Fasting plasma glucose level in the range of 90–99 mg/dL and the risk of the onset of type 2 diabetes: Population‐based Panasonic cohort study 2

Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial

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