Association between vascular endothelial growth factor polymorphism and recurrent pregnancy loss: A systematic review and meta-analysis

Sun, Yaling; Chen, Min; Mao, Baohua; Xia, Cheng; Zhang, Xianping; Xu, Chuanxin

doi:10.1016/j.ejogrb.2017.03.003

Cited by 19 publications

(16 citation statements)

References 20 publications

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“…Although this probably reflects some variation in study characteristics, it is also important to note the inherent heterogeneity of patients with RPL. As demonstrated in other recent reviews on the topic (Jung et al, 2017;Sun et al, 2017), a myriad of underlying aetiologies that contribute to RPL make comparisons between study populations particularly challenging. Importantly, however, all the included studies excluded anatomical contributors to sperm fragmentation, such as varicocele, as well as several other factors such as body mass index, environmental exposures, caffeine and alcohol consumption, and smoking ( Supplemental TABLE 1).…”

Section: Discussionmentioning

confidence: 99%

Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: a systematic review and meta-analysis

Tan

Taşkın

Albert

et al. 2019

Reproductive BioMedicine Online

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Couples with a history of idiopathic recurrent pregnancy loss (RPL) demonstrate higher levels of sperm DNA fragmentation (sDF) than fertile couples. These results support the diagnostic value of sDF over semen analysis in the context of RPL and provide evidence of a possible paternally derived genetic origin of unexplained RPL. ABSTRACTSperm DNA fragmentation (sDF) has emerged as a valuable tool for evaluating male fertility, yet the relationship between DNA fragmentation in the male gamete and idiopathic recurrent pregnancy loss (RPL) remains a topic of ongoing debate. Hence, a meta-analysis was conducted of 12 prospective and 2 retrospective studies involving 530 men with a history of RPL who underwent sDF testing compared with 639 fertile control participants. The main outcome measures were sDF measured by comet assay, TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling (TUNEL), sperm chromatin dispersion (SCD) or sperm chromatin structure assay. Overall, couples with a history of idiopathic RPL demonstrated higher levels of sDF than fertile couples (average mean difference 11.98, P < 0.001). Subgroup analysis demonstrated a similar average mean difference between the RPL and control groups using SCD compared with TUNEL, while mean paternal age and mean sperm motility in the RPL groups tested by meta-regression demonstrated no significant effect on the mean differences in sDF (P > 0.10). These results support the diagnostic value of sDF over standard semen analysis, as well as a possible paternally derived genetic origin of unexplained RPL. Further prospective studies are required to further assess the predictive utility of sDF for assessing couples with unexplained RPL.

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Section: Discussionmentioning

confidence: 99%

Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: a systematic review and meta-analysis

Tan

Taşkın

Albert

et al. 2019

Reproductive BioMedicine Online

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“…11 Specific gene polymorphisms and irregular gene expression are, in turn, recognized as two important risk factors in patients with idiopathic recurrent spontaneous miscarriage (IRSM). 12 Several studies have reported that VEGF polymorphisms and increased risk of IRSM were associated. 13,14 Similarly, other studies showed that abnormal expression of VEGF 15,16 and Cx43 9,10 were related to IRSM.…”

Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Sajjadi

Ghandil

Shahbazian

et al. 2020

J of Obstet and Gynaecol

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Aim Idiopathic recurrent spontaneous miscarriage (IRSM) is one of the pregnancy outcomes that affects 1–2% of women trying to conceive. Specific genotype or aberrant expression of vascular endothelial growth factor A (VEGFA) and connexin 43 (Cx43) as two important genes for embryonic development are deemed to increase the risk of IRSM. Methods To investigate any possible association of VEGFA polymorphisms and aberrant expression of Cx43 and VEGFA with IRSM, we carried out a case–control study including embryo chorionic villus tissues of 100 pregnant women with IRSM and 100 embryo chorionic villus tissues of healthy pregnant women without history of miscarriage. Restriction fragment length polymorphism was used for genotyping of rs699947 (−2578C/A) and rs2010963 (−634G/C) polymorphisms in VEGFA. Besides, quantitative real‐time PCR was performed for VEGFA and Cx43 expression analysis. Results The results showed that the frequency of −634G/C and C/C genotypes was significantly higher in aborted fetuses (P = 0.001 and P < 0.001, respectively) compared to the control group's. However, the frequency of −2578C/A genotypes was not significantly different between the cases and controls. Moreover, a significant higher expression of VEGF (P = 0.0005) and Cx43 (P = 0.0011) was observed in chorionic villus tissues of women with IRSM. Conclusion The finding demonstrated that IRSM frequency may depend on GC and CC genotypes of rs2010963 VEGF polymorphism and expression level of VEGF and Cx43 in IRSM patients was increased.

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“…Many previous studies have suggested that multiple SNPs of VEGF gene increase the risk of diseases such as ovarian malignancies, hypertensive disorder of pregnancy, and idiopathic recurrent pregnancy loss, and thereafter have been confirmed by multiple meta-analyses. Our meta-analysis results revealed certain VEGF gene polymorphisms had a distinct different impact on the pathogenesis of PCOS in contrast to its role in the pathogenesis of other female reproductive system disorders [43][44][45]. There was a significant correlation between VEGF rs2010963 and decreased PCOS susceptibility, suggesting VEGF rs2010963 could be a protective factor for the risk of PCOS.…”

Section: Discussionmentioning

confidence: 73%

Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Zhao

Tang

et al. 2020

Reprod Biol Endocrinol

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Background: Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms are associated with the risk of polycystic ovarian syndrome. However, the results of these studies remain controversial. We performed the present meta-analysis aiming to further investigate the potential relationship between VEGF polymorphisms and susceptibility to PCOS. Methods: The following databases were systematically searched: PubMed, EMBASE, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), and Wanfang Databases. The correlation between VEGF polymorphisms and PCOS risk was assessed by calculating pooled odds ratios (ORs) and their 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were also conducted. Besides, trial sequential analysis (TSA) was done to verify the reliability of the pooled results. Results: 10 relevant case-control studies were incorporated in this meta-analysis, involving 1347 PCOS cases and 1378 controls. The VEGF rs2010963 polymorphism was associated with decreased PCOS risk in the whole population and the Asian populations. The VEGF rs3025039 polymorphism was associated with decreased PCOS susceptibility and the Asian populations, but increased risk of PCOS was observed among the Caucasian populations. In addition, the results of trial sequential analysis (TSA) showed the negative correlation between rs2010963 and PCOS risk, obtained by our meta-analysis, was stable and reliable. Conclusion: Overall, different VEGF gene polymorphisms may exert different effects on PCOS susceptibility. The VEGF rs2010963 polymorphism decreases PCOS susceptibility in both the whole population and the Asian populations, and VEGF rs3025039 polymorphism causes lower PCOS susceptibility in the whole population and the Asian populations but higher in the Caucasian populations.

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Association between vascular endothelial growth factor polymorphism and recurrent pregnancy loss: A systematic review and meta-analysis

Abstract: This meta-analysis showed that only rs1570360 (especially in Caucasians) and rs3025039 (especially in East Asians) may be risk factors for RPL.

Cited by 19 publications

References 20 publications

Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: a systematic review and meta-analysis

Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: a systematic review and meta-analysis

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

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