Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus

Abstract

The aim of the study was to analyse the relationship between the serum level of vascular endothelial growth factor (VEGF) and the incidence of hypertension (HT) in children and adolescents with type I diabetes mellitus (T1DM). One hundred and five patients with T1DM were enrolled in the study. The control group consisted of 30 healthy controls. All the T1DM patients were subjected to biochemical analyses, ophthalmologic examination and 24-h blood pressure monitoring. Besides, all the patients and healthy controls had serum VEGF levels measured with the use of the ELISA methodology. The essence of our research is that patients with T1DM and HT and with microalbuminuria (MA) and diabetic retinopathy (DR) (MA/DR) are characterized by a significantly higher level of VEGF (340.23±93.22 pg ml–1) in blood serum in comparison with the group of T1DM patients without HT and MA/DR (183.6±96.6 pg ml–1) and with healthy controls (145.32±75.58 pg ml–1). In addition, the VEGF level was significantly higher in T1DM patients, who presented all three complications, that is HT, retinopathy and MA in comparison with T1DM patients without HT, but with MA/DR (P=0.036). On the other hand, no statistically significant differences (P=0.19) were noted in the level of VEGF in serum between T1DM patients without HT and MA/DR and the healthy control group. At a further stage of analysis, using the method of multiple regression, it was shown that systolic pressure, HbA1c and duration of disease are independent factors influencing the concentration of VEGF. Summarizing, the measurement of VEGF serum levels allows for the identification of groups of patients who have the highest risk of HT and, subsequently, progression of vascular complications.

Effect of pan retinal photocoagulation on the serum levels of vascular endothelial growth factor in diabetic patients

“…Furthermore, many diabetic complications interfere with VEGF systemic values, which may cause confusion in interpretation of plasma VEGF as a marker of only DR [20][21][22], so the absence of diabetic patients without complications or healthy control group for comparison could be another limitation of this study.…”

No effect of yeast-like fungi on lipid metabolism and vascular endothelial growth factor level in children and adolescents with type 1 diabetes mellitus

“…Our previous studies and studies by other authors have shown that long-term diabetic complications occur after 5 years of the disease [1, 4, 8]. Therefore for the purpose of analyses the study patients with T1DM were divided into two subgroups: patients with duration of diabetes ≤5 years and those with disease duration >5 years.…”

“…Metabolic control of diabetes mellitus is one of the most important factors, but not the only one, that affects the risk of long-term angiopathic complications [4–7]. Several proofs of evidence indicates that the risk of long-term diabetic complications is increased when hyperglycaemia is accompanied by lipid metabolism disorders and high blood pressure values [3, 6, 8]. In our previous studies we showed a correlation between systolic blood pressure values and serum levels of vascular endothelial growth factor (VEGF) in children and adolescents with type 1 diabetes mellitus (T1DM) [8].…”

“…Several proofs of evidence indicates that the risk of long-term diabetic complications is increased when hyperglycaemia is accompanied by lipid metabolism disorders and high blood pressure values [3, 6, 8]. In our previous studies we showed a correlation between systolic blood pressure values and serum levels of vascular endothelial growth factor (VEGF) in children and adolescents with type 1 diabetes mellitus (T1DM) [8]. VEGF is a potent mitogenic and chemotactic factor for endothelial cells, thereby stimulating angiogenesis.…”

Diabetic heart disease: the story continues

“…Recent studies have provided some epidemiological and pathophysiological insights. [26][27][28] Further work is clearly needed.…”