Effect of pan retinal photocoagulation on the serum levels of vascular endothelial growth factor in diabetic patients

Manaviat, Masoud Reza; Rabiei, Maryam; Afkhami-Ardekani, Mohammad; Mohiti-Ardekani, Javad; Bandala-Sanchez, MariaEsther

doi:10.1007/s10792-011-9448-6

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…This technique consists of applying laser burns over the entire retina (except the macula), reducing the metabolic demand and hypoxia of the tissue (1). This arrests the progression of PDR by reducing the levels of hypoxia-driven angiogenic factors such as vascular endothelial growth factor (VEGF) (4). The disadvantage of PRP is the permanent destruction of portions of retina that results from this therapeutic option.…”

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confidence: 99%

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid

2012

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The objectives of this study were to investigate how diabetes mellitus (DM) influences responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underlying mechanism. To this end, we used an ex vivo assay in which neovessels sprouted from retinal explants (isolated from either control or DM mice) when cultured between two layers of collagen and in the presence of vascular endothelial growth factor-A. While DM had no effect on the formation of neovessels, it prevented LPA-induced regression. High-glucose (HG) treatment of retinal explants mimicked the DM phenotype. Similarly, primary retinal endothelial cells (RECs), which were subjected to HG treatment, organized into tubes that were resistant to LPA. HG caused LPA resistance within RECs by elevating ROS, which activated Src-family kinases that stimulated the extracellular signal–related kinase (Erk) pathway, which antagonized LPA-mediated signaling events that were required for regression. This ROS/Src/Erk pathway mechanism appeared to be the same route by which DM induced LPA resistance of retinal neovessels. We conclude that DM/HG reprograms signaling pathways in RECs to induce a state of LPA resistance.

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confidence: 99%

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid

2012

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“…Third, 7 of 19 patients in the IVR group and 5 of the 22 patients in the IVA group had received PRP. Based on previous literature, there is a possibility that previous PRP treatments can influence the VEGF and VIRMs concentrations 57,58 .…”

Section: Discussionmentioning

confidence: 99%

Expression of vascular infarction-related molecules after anti-vascular endothelium growth factor treatment for diabetic macular edema

Sugimoto

Wakamatsu

Miyata

et al. 2019

Sci Rep

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To determine whether an intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) in eyes with diabetic macular edema (DME) affects the vascular infarction-related molecules (VIRMs). Nineteen eyes with DME were treated with 0.5 mg of intravitreal ranibizumab (IVR), and 22 eyes with DME were treated with 2 mg of intravitreal aflibercept (IVA). Blood was collected before, 1 week and 1 month after the injections. Aqueous humor was collected before and 1 month after the injections. The concentration of the VIRMs (cardiac myoglobin, cardiac troponin, intercellular adhesion molecule, monocyte chemotactic protein-1, matrix metalloproteinase-8, placental growth factor [PlGF], tenascin-C, tissue inhibitor of metalloproteinase-1, thrombospondin-2, vascular cell adhesion molecule-1, and VEGF) were determined by the multiplex assay. After the single injection of both types of anti-VEGF agents, the concentration of aqueous VEGF decreased significantly ( P < 0.01). The plasma VEGF was reduced significantly at 1 week after the IVA (93.7 ± 17.6 to 39.5 ± 11.6 pg/ml; P < 0.01) but no significant change was seen after IVR (120.2 ± 11.3 to 137.4 ± 17.7 pg/ml). No significant changes were detected for the other VIRMs in the plasma and aqueous. A single intravitreal injection of anti-VEGF for DME does not significantly affect the concentration of several VIRMs.

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“…This process leads to regression or disappearance of retinal vascular vessels. [52][53][54][55] Pain, development of macular edema, losing visual field, reduction in night vision, color vision loss, retinal scarring, and reduction in contrast sensitivity are seen in several diabetic patients after retinopathy laser therapy. [56][57][58] However, most patients are able to tolerate pain, but shortening the duration of the laser pulse, specifically avoiding prolonged posterior nerves in three to nine hours' position and failing treatment in a few sessions can reduce pain and improve patients' condition.…”

Section: Hypertrichosis After Laser Therapymentioning

confidence: 99%

Evaluation of Laser Effects on the Human Body After Laser Therapy

et al. 2020

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Lasers have wide applications in the treatment and diagnosis of diseases and various medical fields. Laser therapy like the other methods has advantages and disadvantages. Some risks such as bleeding, pain, and infection are created after laser therapy. Explanation and evaluation of laser effects on cell function, tissue, and the body are the aims of this study. We reviewed papers available from 1986 to 2019 about the effects of lasers on cells and tissue. An online search of PubMed, Science Direct and Google scholar using such keywords as "laser", "cell", "tissue", "body" and "side effects" was performed. The laser photons are absorbed by chromophores, resulting in the target heating and localized damage. Laser irradiation alters cellular metabolism and cellular functions. These alterations may be accompanied by undesired side effects which can be monitored via metabolites level change in the body. Based on this finding, laser therapy may be associated with several side effects and complications; therefore, before treatment, the determination of laser types and their properties is necessary to avoid creating side effects. The advantages and disadvantages of the treatment type should be considered in order to choose the best treatment with the least side effects. The patients’ awareness of possible side effects before treatment and also an effective follow-up and management of patients after action are two important points in laser therapy. Training curriculum definition should be determined for laser applicant qualifications in different medical fields.

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Effect of pan retinal photocoagulation on the serum levels of vascular endothelial growth factor in diabetic patients

Cited by 8 publications

References 19 publications

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid

Expression of vascular infarction-related molecules after anti-vascular endothelium growth factor treatment for diabetic macular edema

Evaluation of Laser Effects on the Human Body After Laser Therapy

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