Association Between Visceral Adipose Tissue Area and Coronary Plaque Morphology Assessed by CT Angiography

Ohashi, Norihiko; Yamamoto, Hideya; Horiguchi, Jun; Kitagawa, Toshiro; Kunita, Eiji; Utsunomiya, Hiroto; Oka, Takahiro; Kohno, Nobuoki; Kihara, Yasuki

doi:10.1016/j.jcmg.2010.06.014

Cited by 73 publications

(63 citation statements)

References 29 publications

(32 reference statements)

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“…The amount of plaque non-calcified plaque, as well as with CT-derived features of plaque vulnerability (low attenuation, positive remodeling). 26 The present study, using high-resolution intravascular imaging, extends these previous findings, demonstrating a significant association of obesity with a thin fibrous cap and with macrophage infiltration, in addition to increased plaque burden and the amount of lipid-rich plaque. In the development and progression of atherosclerosis, macrophage infiltration of the coronary arterial wall with formation of foam cells represents a pivotal process, and macrophage-induced degradation of the fibrous cap matrix is an important contributor to plaque instability and disruption.…”

Section: Obesity Overall Plaque Burden and Plaque Phenotypesupporting

confidence: 86%

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―

Rosa

Vasa‐Nicotera

Leistner

et al. 2017

Circ J

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ticular morphological features, which are differentially connected to the risk of plaque disruption and subsequent thrombus apposition, risk of vessel occlusion and acute coronary events. 2 Optical coherence tomography (OCT) is a light-based intravascular imaging modality that allows for high-resolution visualization of the coronary atherosclerotic plaques. 3 Currently, OCT provides the most detailed insights into plaque characteristics, allowing the measurement of lipid-pool extension and the thickness of the fibrous cap, as well as the identification of local plaque inflammation, all of which may represent key factors in A therosclerosis is a multifactorial disease that results from a complex interaction between genetic predisposition and well-recognized cardiovascular risk factors (CVRF), such as diabetes mellitus, arterial hypertension, hypercholesterolemia, smoking, obesity and age. The relationship between CVRF and the risk of experiencing a coronary event is widely acknowledged. 1 Nevertheless, the mechanisms underlying the role of individual risk factors in the development and progression of atherosclerotic plaques are currently not fully understood. Pathological and imaging studies have demonstrated that the morphological composition in large part reflects the fate of an atherosclerotic plaque. 2 It has been demonstrated that "stable" and "vulnerable" plaques show distinct and parEditorial p 1100 The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged.Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.

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Section: Obesity Overall Plaque Burden and Plaque Phenotypesupporting

confidence: 86%

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―

Rosa

Vasa‐Nicotera

Leistner

et al. 2017

Circ J

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show abstract

“…As similar results, apart from those studies using state-ofthe-art methodology (bidimensional echocardiography and coronary angiography) [5][6][7] , more recent investigations have shown, by cardiac computed tomography scan, a significant association between epicardial fat and coronary artery disease 14,16 . However, contrary to our study, a significant association between epicardial fat and the extent and clinical presentation of CAD has also been identified [5][6][7] .…”

Section: Discussionsupporting

confidence: 63%

Parâmetros ecocardiográficos de deposição de gordura epicárdica e sua relação com doença arterial coronariana

Mustelier¹,

Rego²,

González³

et al. 2011

Arq. Bras. Cardiol.

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“…31) Furthermore, it has been reported that visceral adipose accumulation is associated with the presence of non-calcified plaque and plaque vulnerability, as detected by CCTA. 32) It has been reported that a correlation good for CT value OK of plaque and non-calcified plaque was seen in CCTA, 33) and it has also been reported that low attenuation coronary plaques on MDCT can Data are presented as mean ± SD or number (%). V/S indicates the ratio of visceral fat to subcutaneous fat.…”

Section: Discussionmentioning

confidence: 98%

Is Visceral Fat Really a Coronary Risk Factor?

et al. 2013

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SummaryMetabolic syndrome (MS) is currently considered to be a risk factor for arteriosclerotic disease. The accumulation of visceral fat leads to arteriosclerotic disease after other risk factors have developed and either direct or mutual effects occur. The aim of this study was to verify whether visceral fat serves as an independent coronary risk factor. A total of 3157 patients who had undergone multi-detector computed tomography (MDCT) were analyzed via computed tomographic angiography and the measurement of their visceral fat area. Coronary arteries with > 70% stenosis were considered to be significant. The visceral fat area was measured at the umbilical level, and an area of 100 cm 2 or more was defined as visceral obesity. Coronary risk factors (ie, hypertension, dyslipidemia, diabetes mellitus, family history, and smoking) were obtained from the patient medical records. The patients were divided into two groups: a visceral obesity group, 1130 patients (137.0 ± 31.1 cm 2 ) and a nonvisceral obesity group, 2027 patients (57.3 ± 25.8 cm 2 ). A significant difference in the incidence of coronary stenosis between the two groups was observed. According to multivariable analysis, the factors affecting coronary stenosis were age, gender, dyslipidemia, diabetes mellitus, and the ratio of visceral to subcutaneous fat. Visceral obesity was not found to be an independent coronary risk factor. Visceral obesity demonstrated the predominant presence of coronary risk factors. (Int Heart J 2013; 54: 273-278)

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Association Between Visceral Adipose Tissue Area and Coronary Plaque Morphology Assessed by CT Angiography

Cited by 73 publications

References 29 publications

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―

Parâmetros ecocardiográficos de deposição de gordura epicárdica e sua relação com doença arterial coronariana

Is Visceral Fat Really a Coronary Risk Factor?

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Association Between Visceral Adipose Tissue Area and Coronary Plaque Morphology Assessed by CT Angiography

Cited by 73 publications

References 29 publications

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study ―

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study ―

Parâmetros ecocardiográficos de deposição de gordura epicárdica e sua relação com doença arterial coronariana

Is Visceral Fat Really a Coronary Risk Factor?

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Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―

Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study ―