Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection

Ayesh, Mahmoud H.; Jadalah, Khaled; Awadi, Eiman Al; Alawneh, Khaldoon; Khassawneh, Basheer

doi:10.1016/j.bjid.2013.01.009

Cited by 19 publications

(25 citation statements)

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“…Firstly, over half (54.5%) of patients with AIG also had evidence of bacterial infection by biopsy and/or UBT, suggesting the possibility that IM may have also been related to H. pylori rather than being exclusively attributed to hypochlorhydria from autoimmune loss of parietal cells. Moreover, it may support emerging evidence of a causative link between H. pylori and autoimmune gastritis, as evidenced by reports of a significant association between H. pylori infection and presence of APCA and antibodies to an intrinsic factor (AIFA) (22). In our study, 44% of AIG patients with negative histology had evidence of infection on UBT.…”

Section: Discussionsupporting

confidence: 88%

Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Galiatsatos

Wyse²,

Szilagyi³

2020

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 88%

Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Galiatsatos

Wyse²,

Szilagyi³

2020

Turk J Gastroenterol

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“…These results are in agreement with previous studies from other Arabic countries including Jordan and Saudi Arabia. 16 , 17 There was no significant correlation between H. pylori infection and age. These results are in agreement with Khan who concluded that H. pylori infection is acquired early in life and there is no rise in the incidence with advancing age.…”

Section: Discussionmentioning

confidence: 85%

Hematological parameters, serum iron and vitamin B 12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori : a case–control study

Mwafy

Afana

2018

Hematology, Transfusion and Cell Therapy

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ObjectiveThis study aimed to investigate the relationship between hematological parameters, serum iron, and vitamin B12 levels in adult hospitalized Palestinian patients infected with Helicobacter pylori.MethodsThis case–control study included 150 adult (18–50 years old) patients infected with H. pylori and 150 healthy adults. A complete blood count was performed, and serum iron and vitamin B12 levels of the patients were measured, statistically analyzed and compared with the control group. All parameters in cases were reassessed after the triple treatment of omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. for 14 successive days. The triple treatment was the same for males and females.ResultsThe results revealed that the mean levels of hemoglobin, red cell count, white cell count and hematocrit were significantly lower and the red blood cell distribution width significantly higher in cases compared to controls, while no significant differences were found for mean corpuscular volume, mean corpuscular hemoglobin and platelet count. Serum vitamin B12 and iron levels were significantly lower in cases compared to controls (262.5 ± 100.0 vs. 378.2 ± 160.6 pg/mL and 71.6 ± 24.8 vs. 80.1 ± 20.7 μg/dL, respectively). Vitamin B12 and serum iron increased significantly and was restored to close to normal levels after medical treatment.ConclusionsH. pylori infection appears to cause decreases in vitamin B12, iron levels and some hematological parameters. However, these were almost normalized after treatment with omeprazole, amoxicillin and clarithromycin. H. pylori is associated with vitamin B12 and iron deficiency, thus, this may be a useful marker and a possible therapeutic agent of anemic patients with gastritis.

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“…Furthermore, Ayesh et al found that people with H . pylori infection had lower levels of vitamin B12 [ 36 ]. In addition, low plasma levels of vitamin B12 may be associated with low bone mineral density [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Patients with Helicobacter pylori Infection and the Subsequent Risk of Developing Osteoporosis after Eradication Therapy: A Nationwide Population-Based Cohort Study

et al. 2016

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PurposePrevious studies have reported conflicting results on the association between Helicobacter pylori infection and osteoporosis. A few studies have discussed the influence of H. pylori eradication therapy on bone mineral density.MethodsWe assessed the prevalence of osteoporosis among the H. pylori-infected population in Taiwan and the influence of early and late H. pylori eradication therapy on bone mineral density.ResultsUsing data from Taiwan's National Health Insurance Research Database, we identified 5,447 patients who received H. pylori eradication therapy from 2000 to 2010 and 21,788 controls, frequency-matched according to age, sex, and year of receiving H. pylori eradication therapy. Those who received H. pylori eradication therapy were divided into two groups based on the time interval between the diagnosis of a peptic ulcer and commencement of eradication therapy. The risk of developing osteoporosis was higher in the early H. pylori treatment cohort (hazard ratio [HR] = 1.52, 95% confidence interval [CI] = 1.23–1.89) and late H. pylori treatment cohort (HR = 1.69, 95% CI = 1.39–2.05), compared with the risk in the control cohort. When followed for less than 5 years, both the early and late cohorts had a higher risk of developing osteoporosis (HR = 1.69, 95% CI = 1.32–2.16 and HR = 1.72, 95% CI = 1.38–2.14). However, when the follow-up period was over 5 years, only the late eradication group exhibited a higher incidence of osteoporosis (HR = 1.62, 95% CI = 1.06–2.47).ConclusionThe development of osteoporosis is complex and multi-factorial. Via this population-based cohort study and adjustment of possible confounding variables, we found H. pylori infection may be associated with an increased risk of developing osteoporosis in Taiwan. Early eradication could reduce the influence of H. pylori infection on osteoporosis when the follow-up period is greater than 5 years. Further prospective studies are necessary to discover the connection of H. pylori and osteoporosis.

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Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection

Cited by 19 publications

References 13 publications

Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Hematological parameters, serum iron and vitamin B 12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori : a case–control study

Analysis of Patients with Helicobacter pylori Infection and the Subsequent Risk of Developing Osteoporosis after Eradication Therapy: A Nationwide Population-Based Cohort Study

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