Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Galiatsatos, Polymnia; Wyse, Jonathan; Szilagyi, Andrew

doi:10.5152/tjg.2014.6476

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…In the present work, no information concerning treatment with proton pump inhibitors, antibiotics or other medicines was found in the medical records analyzed, since these records were made along diagnosis establishment and, therefore, prior prescription. In addition, the literature evidences that a significant number of false negative in histopathological results occur regardless the staining method used, variability in pathologists' microscopy skills, H. pylori distribution through the stomach in gastritis with atrophy and intestinal metaplasia, local production of antimicrobial factors and hypochlorhydria (21,22) .…”

Section: Discussionmentioning

confidence: 99%

Gender, Age, Endoscopic Findings, Urease and Helicobacter Pylori: All Uncorrelated Within a Sample of a High Gastric Cancer Prevalence Population in Amazon

Miranda

Caldato²,

Said³

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.

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Section: Discussionmentioning

confidence: 99%

Gender, Age, Endoscopic Findings, Urease and Helicobacter Pylori: All Uncorrelated Within a Sample of a High Gastric Cancer Prevalence Population in Amazon

Miranda

Caldato²,

Said³

et al. 2019

Arq. Gastroenterol.

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“…This figure is similar to that recorded by other studies. 8,25,30 Intestinal metaplasia may cause lower diagnostic accuracy of H. pylori with histologic examination. 11 As clearly known, H. pylori selectively lives in gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Premalignant changes associated chronic gastritis in Karbala Province: multi institutional study

AlSafi

Alqanbar

Al-Sabbagh

2019

J. Contemp. Med. Sci.

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Objectives: The aim of this study was to investigate the prevalence of gastric premalignant changes as gastric atrophy, intestinal metaplasia and dysplastic changes in patients underwent esophagogastroduodenoscopy in three health institutions in Karbala province. Methods: The data was collected from patients attended the endoscopy units during a period from January to September 2018 in three medical centers in holy Karbala/ Iraq, Al Hussein teaching hospital, Imam Zain Al Abedin hospital and Imam AL Hujjah hospital. It includes 215 males and 285 females who were subjected to esophagogastroduodenoscopy (EGD) from whom mucosal biopsies were taken. These biopsies were stained by Giemsa to detect H. pylori organisms. Results: The mean age of patients was (40.9 +/- 15 years SD). H. Pylori infection was demonstrated in (71%) patients, (19.4%) were presented with glandular atrophy, (7.4%) out of 500 patients had intestinal metaplasia and only 6 (1.2%) patients had dysplastic changes. there was a significant statistical relation between gastric glandular atrophy and age, p value (0.03). there was a significant statistical relation between glandular atrophy and infection with H. Pylori, p value (0.001). there was a significant negative relation between H. Pylori infection and the existence of intestinal metaplasia, p value (0.0001). this study show a significant statistical relationship between the existence of intestinal metaplasia and the occurrence of dysplastic changes, P value (0.001). Conclusion: the current study show a significant relation between aging and the existence of gastric glandular atrophy. There was a significant relation between each of gastric glandular atrophy and intestinal metaplastic changes with the H. pylori infection. there was a significant relation between gastric intestinal metaplasia and dysplastic changes.

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“…From a mechanistic standpoint, it is plausible that increased or decreased diversity of the microbiota can be associated with the development of gastric cancer. Although present in gastric tissue in >90% of patients with active acute gastritis, 6,7 H. pylori is absent in gastric tissues in the large majority of patients with advanced AG, IM 9 or gastric cancer 8 even when serology is positive; this suggests the disappearance of active H. pylori infection during the later stages of gastric cancer development 29 ( Table 1). The loss of H. pylori and impairment of acid secretion in these lesions may facilitate the colonization of other bacteria in the stomach.…”

Section: Gastric Cancer Development and Diversity Of The Microbiotamentioning

confidence: 99%

The role of gastric microbiota in gastric cancer

2020

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Gastric cancer represents one of the leading causes of cancer deaths worldwide. Helicobacter pylori (H. pylori) infection is the strongest risk factor associated with gastric cancer. Due to new molecular techniques allowing greater identification of stomach microbes, investigators are beginning to examine the role that bacteria other than H. pylori play in gastric cancer development. Recently, researchers have investigated how the composition of the gastric microbiota varies among individuals with various stages of gastric disease. Specific microbes residing in the stomach have been preferentially associated with gastric cancer patients compared to individuals with a healthy gastric mucosa. Studies conducted on the insulin-gastrin (INS-GAS) transgenic mouse model have provided additional insight into the association between the gastric microbiota and gastric cancer. The purpose of this article is to review the current state of literature on the relationship between the gastric microbiota and gastric cancer based on clinical studies performed to date.

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Accuracy of biopsies for Helicobacter pylori in the presence of intestinal metaplasia of the stomach

Abstract: Background/Aims: Gastric cancer is the second leading cause of cancer-related death worldwide.

Cited by 10 publications

References 21 publications

Gender, Age, Endoscopic Findings, Urease and Helicobacter Pylori: All Uncorrelated Within a Sample of a High Gastric Cancer Prevalence Population in Amazon

Gender, Age, Endoscopic Findings, Urease and Helicobacter Pylori: All Uncorrelated Within a Sample of a High Gastric Cancer Prevalence Population in Amazon

Premalignant changes associated chronic gastritis in Karbala Province: multi institutional study

The role of gastric microbiota in gastric cancer

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