The influence of donor age on the outcome of kidney transplantation (TX) was evaluated in 169 patients who received a primary cadaver kidney transplant at our center between September 16,1984, and December 31,1990. All the patients received cyclosporin A as part of the immunosuppressive protocol. Patients were grouped according to donor age: low donor age (LDA; donor age range 12-25 years), medium donor age (MDA; range 26-50 years) and high donor age (HDA; range 51-66 years). There were no differences between groups in graft and patient survival, and multivariate analysis did not show any effect of donor age on those parameters. Proteinuria/day and number of rejection episodes did not differ between groups either. Immediate diuresis was more frequent in group LDA than in the other two groups (73.8, 54.7 and 57.1%, respectively; p < 0.05) and immediate diuresis resulted as a weak positive prognostic factor for graft outcome at multivariate analysis (p = 0.05). At both univariate and multivariate analyses, donor age resulted inversely correlated with creatinine clearance (C_Cr) at every period after TX but the 5th year, with r² from 0.12 to 0.23 (p < 0.01). The LDA group had significantly better C_Crthan the HDA group at every period after TX but for the 5th year (the MDA group behaved intermediately). Moreover, in the 65 patients with a follow-up of 4 years or more, not only did the LDA group have the best C_Cr (LDA vs. MDA and HDA: p < 0.02) but also C_Cr remained roughly stable with time in groups LDA and MDA while it declined progressively with time in group HDA. The influence of donor age on hypertension after TX was negligible when compared to that of dialytic age and recipient sex. Our data show that kidneys from donors 12-25 years old give the best functional results, while those from donors over 50 are associated with the lowest kidney function. Moreover, if the reduced frequency of immediate diuresis and the progressive decline of C_Cr with time are taken into account, kidneys from donors over 50 are also probably associated with reduced graft survival in the long term (after the 10th year). We suggest that kidneys from donors over 50 may be used, but they should be probably given to patients with a life expectation of no more than 10-15 years.

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BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.

Objetivo: Identificar os achados mais comuns encontrados na EDA em pacientes de um hospital do município de Belém-PA. Métodos: Trata-se de um estudo do tipo observacional, analítico e transversal, por meio da análise de laudos das endoscopias digestiva alta (EDA) realizadas em um hospital de Belém-PA, durante 2019, identificando os principais achados desses exames. Resultados: Foram incluídos no estudo 1358 pacientes e a média de idade foi 54 anos. Quase todos os indivíduos (98,2%) tinham alterações gástricas. 5,7% (77 indivíduos) tinham alterações duodenais. 36,2% dos indivíduos tinham alterações esofágicas. 0,8% (11 indivíduos) tinham exames sugestivos de neoplasias apenas 25 (1,8%) deles não apresentava nenhuma alteração na endoscopia. Dentre os pacientes com alterações gástricas, 990 (73,3%) tinham gastrite enantematosa de antro. Nas alterações duodenais, 71,4% dos indivíduos tinham bulboduodenite erosiva. A maior parte (446 ou 90,8%) dos achados no esôfago era de esofagite erosiva. Quanto aos achados sugestivos de neoplasias, 72,7% deles foram encontrados no estômago. Foi verificada a associação entre sexo, faixa etária e a presença de alterações. Conclusão: A realização de uma EDA de qualidade e sua indicação correta é imprescindível para diagnósticos precisos. As principais patologias encontradas foram de origem inflamatória, além de lesões pré-malignas e malignas.

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