Association between vitamin D receptor BsmI polymorphism and bone mineral density in pediatric patients

Abstract

Background:Vitamin D and the vitamin D receptor (VDR) are important in the metabolic processes that affect bone mineral density (BMD). However, the effect of VDR BsmI polymorphism on BMD in pediatric patients is still unclear.Methods:Eligible studies were identified from the following electronic databases: PubMed, Embase, the Cochrane Library, and the Chinese CNKI and Wanfang databases before October 1, 2016. Data were extracted from the eligible studies, and associations between VDR BsmI polymorphism and BMD in pediatric patients were estimated with weighted mean differences (WMDs) and 95% confidence intervals (CIs). Subgroup analysis of ethnicity and sensitivity analyses were used to identify sources of heterogeneity.Results:A significant difference was observed between VDR BsmI polymorphism and pediatric BMD levels of the lumbar spine (LS) in the corecessive model (bb vs BB + Bb: WMD = −0.23, 95% CI [−0.35, −0.11], P < 0.01). No significant relationship was found in the dominant, recessive, or codominant models for LS BMD (BB vs Bb: WMD = −0.56, 95% CI [−1.58, 0.46], P = 0.29; BB vs bb: WMD = −0.54, 95% CI [−1.49, 0.41], P = 0.27; and BB vs Bb + bb: WMD = −0.45, 95% CI [−1.71, 0.26], P = 0.22). In addition, we found no remarkable association between the BsmI polymorphism and BMD levels of the femoral neck (FN) in children (BB vs Bb: WMD = −1.08, 95% CI [−3.13, 0.96], P = 0.30; BB vs bb: WMD = 0.98, 95% CI [−0.89, 2.85], P = 0.31; BB vs Bb + bb: WMD = −0.061, 95% CI [−0.30, 0.17], P = 0.61; and bb vs BB + Bb: WMD = 0.82, 95% CI [−0.59, 2.32], P = 0.25).Conclusion:Our meta-analysis found that the VDR BsmI genetic polymorphism was correlated with LS BMD level in pediatric patients: compared with those with the B allele, children with the bb genotype were less likely to have lower BMD levels. No significant difference was identified in the pediatric FN BMD levels.

Current Knowledge Regarding the Interaction Between Oral Bone Metabolic Disorders and Diabetes Mellitus

“…Vitamin D achieves its effects by regulating the metabolism of calcium and phosphorus, and it is often used to treat calcium and phosphorus imbalances in OP patients (106). Furthermore, it contributes to calcium absorption and deposition in bone (107,108). In diabetic patients, who have a higher risk of fracture, this risk is reduced by increasing the serum vitamin D concentration (109).…”

Вітамін D У Генетичному Аспекті Та Його Роль За Цукрового Діабету 1-Го Типу

“…Наразі в наукових базах даних бракує інформації про зв'язок між рівнем вітаміну D, однонуклеотидними поліморфізмами в генах, які відповідають за його метаболізм, МЩКТ у пацієнтів із ЦД1, надто з точки зору вивчення цих компонентів у комплексі. Генетичні дослідження такого плану, які проводилися, зазвичай охоплювали когорти здорових дорослих осіб, дітей або жінок у постменопаузі [37,38].…”

The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes

“…Nie odnotowano zależności występowania Bsm1 w odniesieniu do zaburzeń mineralizacji i gęstości kości [31,34]. Odmiana polimorficzna Bsm1 została zidentyfikowana również w zaburzeniach BMD odcinka lędźwiowego kręgosłupa u dzieci, podczas gdy nie wykazano takiej zależności dla BMD szyjki kości udowej [40]. Nie stwierdzono zależności występowania Taq1 i zmian w gęstości mineralnej kości oraz ryzyka osteoporozy dla kobiet rasy kaukaskiej [31].…”