Association between Vitamin D Status and Premenstrual Symptoms

Jarosz, Alicia Caroline; El-Sohemy, Ahmed

doi:10.1016/j.jand.2018.06.014

Cited by 17 publications

(11 citation statements)

References 43 publications

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Section: Discussionsupporting

confidence: 57%

“…Inverse associations between vitamin D status or plasma 25(OH)D concentrations and PMSx have been reported previously [14,15]. Our earlier analysis of the TNH population showed that women with inadequate vitamin D status had increased odds of experiencing several common premenstrual symptoms, compared to vitamin D-sufficient women [15]. Similarly, a case-control study nested in the Nurses' Health Study II found an inverse association between 25(OH)D concentrations and premenstrual depression, diarrhea, fatigue, and breast ache [14].…”

Section: Discussionsupporting

confidence: 57%

“…Evidence from a recent meta-analysis indicates that vitamin D supplementation is effective in treating PMS, but it is not clear which specific symptoms are alleviated [13]. Plasma 25(OH)D concentrations have also been shown to be inversely associated with the presence or severity of some PMSx [14,15]. Though, the exact mechanism behind these findings remains equivocal, as there is no evidence to suggest that vitamin D metabolites differ during different phases of the menstrual cycle [16].…”

Section: Introductionmentioning

confidence: 99%

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Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

et al. 2021

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Background Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR). Objective To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype. Methods Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA was obtained from blood samples to genotype for a common VDR single nucleotide variant, rs796858. Using logistic regression, odds of experiencing PMSx were compared between vitamin D-sufficient and insufficient women, stratified by genotype. Results Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue (OR, 2.53; 95% CI, 1.40, 4.56) and nausea (OR, 2.44; 95% CI, 1.00, 5.95). Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue (OR, 0.44; 95% CI, 0.20, 0.97) and increased appetite (OR, 0.48; 95% CI, 0.22, 1.04). Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype (OR, 1.78; 95% CI, 1.03, 3.07). VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039). Conclusion We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

et al. 2021

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“…The most pronounced effects were obtained when supplementation was ordered in women with vitamin D hypovitaminosis [37]. In a cross-sectional study (not included in this review due to the lack of a control group), women with inadequate vitamin D status had an increased risk of experiencing some premenstrual symptoms such as mild confusion and severe fatigue or anxiety [41]. Results of two independent systematic reviews of the literature [42,43] revealed that vitamin D may play an important role in PMS occurrence; however, more randomized controlled trials are needed.…”

Section: Discussionmentioning

confidence: 99%

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Granda¹,

Szmidt²,

Kałuża³

2021

Antioxidants

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Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.

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“…Dietary changes, such as reducing alcohol, caffeine, and sugar intake and increasing complex carbohydrate intake during the luteal phase, may alleviate PMDD symptoms; these changes are frequently recommended, but systematic evaluations of their efficacy are lacking [26]. Vitamin D supplementation benefited women with PMDD who experienced premenstrual symptoms of cramps, fatigue, anxiety, desire to be alone, and confusion; a clinical trial showed that these symptoms are related to inadequate vitamin D intake [27]. Nutritional supplementation with calcium, vitamin B6 [28], and omega 3 fatty acids [29] have been effective in improving premenstrual symptoms.…”

Section: Discussionmentioning

confidence: 99%

Insomnia, Inattention and Fatigue Symptoms of Women with Premenstrual Dysphoric Disorder

Lin

et al. 2021

IJERPH

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Aim: Premenstrual dysphoric disorder (PMDD) has predictable, cyclic, psychological, and somatic symptoms, such as sleep problems. They result in functional impairment, are aggravated in the late luteal phase of the menstrual cycle, and are resolved by menstruation. The present study evaluated the insomnia, inattention, and fatigue symptoms of PMDD and their fluctuations during the menstrual cycle. Methods: A total of 100 women were diagnosed as having PMDD based on psychiatric interviews and a prospective investigation of three menstrual cycles. A total of 96 individuals without PMDD were recruited as controls. Their symptoms, namely insomnia, inattention, and fatigue as well as functional impairment were assessed by using the premenstrual symptoms screening tool, the Pittsburgh insomnia rating scale, the attention and performance self-assessment scale, and the fatigue-assessment scale during both premenstrual and follicular phases. Results: In both the premenstrual and follicular phases, women with PMDD experienced more severe insomnia, inattentiveness, and fatigue than did women in the control group. A paired t-test demonstrated that women with PMDD had more severe severity insomnia, inattentiveness, and fatigue in the luteal phase than in the follicular phase. A repeated-measures analysis of variance demonstrated that the interaction period of PMDD and a menstrual cycle was significantly associated with insomnia, inattentiveness, and fatigue. A further correlation analysis demonstrated that all three symptoms were positively associated with self-reported functional impairment due to PMDD. Conclusions: Our results demonstrated that women with PMDD experienced an exacerbation of insomnia, memory problems, difficulty maintaining focus, and fatigue in the premenstrual phase. These symptoms are correlated with PMDD symptoms severity and functional impairment, and as such, they should be evaluated, and interventions should be employed in the late luteal phase of women with PMDD.

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Association between Vitamin D Status and Premenstrual Symptoms

Cited by 17 publications

References 43 publications

Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Insomnia, Inattention and Fatigue Symptoms of Women with Premenstrual Dysphoric Disorder

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