Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

Abstract

Background Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR). Objective To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype. Methods Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA was obtained from blood samples to genotype for a common VDR single nucleotide variant, rs796858. Using logistic regression, odds of experiencing PMSx were compared between vitamin D-sufficient and insufficient women, stratified by genotype. Results Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue (OR, 2.53; 95% CI, 1.40, 4.56) and nausea (OR, 2.44; 95% CI, 1.00, 5.95). Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue (OR, 0.44; 95% CI, 0.20, 0.97) and increased appetite (OR, 0.48; 95% CI, 0.22, 1.04). Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype (OR, 1.78; 95% CI, 1.03, 3.07). VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039). Conclusion We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype.

Premenstrual syndrome. Nutrient support options

“…Jarosz и соавт. показано, что пациентки с полиморфизмом генов рецептора витамина D в условиях недостаточности витамина D (менее 50 нмоль/л) более часто испытывают слабость и/или повышение аппетита как проявления ПМС [39]. Недостаточность витамина D, в свою очередь, напрямую ассоциирована с симптомами нагрубания молочных желез (ОР = 1,27; 95% ДИ: 1,03-1,55), мышечных болей (ОР = 1,36; 95% ДИ: 0,41-4,45) [40][41][42][43].…”

Plasma Carotenoids and Premenstrual Symptoms in a Multi-Ethnic Population of Young Women

“…However, considerable variation exists in the type and severity of symptoms that women experience. Some of this variation may be due, in part, to factors such as differences in lifestyle, age, genetics, diet and nutritional status [5][6][7][8][9].…”

Correction to: Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

“…https://doi.org/10.1186/s12263-021-00696-2 Following publication of the original article [1], it was brought to our attention that the article had published with incomplete equal contributions information: the third author, who contributed equally along with the first and second authors, had not been marked as contributing equally.…”