Association between Vogt-Koyanagi-Harada Syndrome and HLA-DR1 and -DR4 in Hispanic Patients Living in Southern California

HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada’s disease in Southern California

“…A study looking at HLA associations with VKH disease in mestizo individuals in Southern California found either HLA-DR1 or HLA-DR4 in 84% of patients by means of serologic techniques [3]. Indeed, HLA-DR1 had a higher relative risk than HLA-DR4 (4.11 vs 1.96, respectively) in this population [3].…”

Cytokines and Chemokines in Uveitis - Is there a Correlation with Clinical Phenotype?

“…108 The exact cause of this condition remains unknown, but cell-mediated autoimmunity directed against a melanocyte antigen, which may be a member of the tyrosinase family of proteins, appears to be the common mechanism. 144 VKH is associated with HLA-DR1 and HLA-DR4, 145 highly related to HLA-DRB1*0405 in people of Japanese and Asian heritage. 146,147 In experimental models, tyrosinase family proteins have been documented to induce an autoimmune disease that strongly resembles VKH.…”

Pigmentary disorders of the eyes and skin

“…VKH likely results from the complex interplay of genetic and environmental factors. [120][121][122][123][124][125][126][127][128] There are several criteria required for diagnosis. 129 …”