Association between Waste Management and Cancer in Companion Animals

Marconato, Laura; Leo, Chiara; Girelli, R.; Salvi, Satish; Abramo, Francesca; Bettini, Giuliano; Comazzi, S.; Nardi, Paola De; Albanese, Francesco; Zini, Eric

doi:10.1111/j.1939-1676.2009.0278.x

Cited by 44 publications

(38 citation statements)

References 29 publications

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“…Companion animals also benefit from oncological therapies that are used in human medicine. Companion animals share the same environment as their owners and can therefore act as sentinels for recognition of environmental factors implicated in oncogenesis (Bukowski and Wartenberg, 1997;Backer et al, 2001;Gamlem et al, 2008;Marconato et al, 2009;Bettini et al, 2010). Companion animals, and dogs in particular, share significantly more of their genome with man than do rodents (Pinho et al, 2012).…”

Section: Introductionmentioning

confidence: 95%

The Swiss Canine Cancer Registry: A Retrospective Study on the Occurrence of Tumours in Dogs in Switzerland from 1955 to 2008

Grüntzig

Graf

Hässig

et al. 2015

Journal of Comparative Pathology

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Diagnostic records are a key feature of any cancer epidemiology, prevention or control strategy for both human beings and animals. Thus, the information stored in human and animal cancer registries is essential to comparative epidemiologic, pathogenic and therapeutic research. This study presents the Swiss Canine Cancer Registry, compiled between 1955 and 2008. The data consists of pathology diagnostic records issued by three veterinary diagnostic laboratories in Switzerland. The tumours are classified according to the International Classification of Oncology for Humans (ICD-O-3) guidelines: tumour type, malignancy and body location (WHO, 2013). The dogs are classified according to breed, age, sex, castration status and place of residence. The diagnostic data were correlated to the relative dog population and the occurrence of cancer in dogs was thus investigated. In 121,963 canine patients 67,943 tumours were diagnosed. 47.07% of which were malignant tumours. The most common tumour location was the skin (37.05%), followed by mammary glands (23.55%) and soft tissue (13.66%). The most common tumour diagnoses were epithelial (38.45%), mesenchymal (35.10%) and lymphatic tumours (13.23%). The results are compared with other canine registries. Similarities to tumour distribution and incidence in other findings are listed and specific difficulties in comparison are pointed out. We hope that this study will mark the beginning of a continuous registration of dog tumours in Switzerland, which, in turn, will serve as a reference for research in the fields of animal and human oncology. The diagnostic data were correlated to the relative dog population and the 25 occurrence of cancer in dogs was thus investigated. In 121,963 canine patients 26 67,943 tumours were diagnosed. 47.07% of which were malignant tumours. The 27 most common tumour location was the skin (37.05%), followed by mammary glands 28 (23.55%) and soft tissue (13.66%). The most common tumour diagnoses were 29 epithelial (38.45%), mesenchymal (35.10%) and lymphatic tumours (13.23%). 30The results are compared with other canine registries. Similarities to tumour 31 distribution and incidence in other findings are listed and specific difficulties in 32 comparison are pointed out. We hope that this study will mark the beginning of a 33 continuous registration of dog tumours in Switzerland, which, in turn, will serve as a 34 reference for research in the fields of animal and human oncology. 35 36

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Section: Introductionmentioning

confidence: 95%

The Swiss Canine Cancer Registry: A Retrospective Study on the Occurrence of Tumours in Dogs in Switzerland from 1955 to 2008

Grüntzig

Graf

Hässig

et al. 2015

Journal of Comparative Pathology

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“…Canine lymphoma represents 5-7% of canine tumors and a majority (85%) of canine hematopoetic disease (Ettinger, 2003;Vail and Young, 2013). In addition, tobacco smoke, environmental chemicals, and waste emissions are considered possible risk factors (Marconato et al, 2009;Gavazza et al, 2001) Clinical Signs Multicentric high-grade lymphoma (MHGL) accounts for the majority of reported cases of canine lymphoma. In humans, data implicate the herbicide 2,4-dichlorophenoxyacetic acid as a cause of non-Hodgkin's lymphoma, but studies in dogs with similar conclusions have come under scrutiny (MacEwen and Young, 1991).…”

Section: A Lymphomasmentioning

confidence: 99%

Biology and Diseases of Dogs

Nemzek

Lester

Wolfe

et al. 2015

Laboratory Animal Medicine

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“…Environmental factors have been investigated and are suspected in the development of Non-Hodgkin's lymphoma, especially the herbicide 2, 4-dichlorophenoxyacetic acid (GARABRANT, 2002), tobacco smoke (STAGNARO et al, 2004) and air pollution (GAVAZZA et al, 2001;PAZ et al, 2009;MARCONATO et al, 2009;GOUVEIA et al, 2010;MERLO et al, 2010;ABBA et al, 2011;CHAKRABORTY, 2011;KLIUCININKAS et al, 2011;LIOY et al, 2011).…”

Section: Introductionmentioning

confidence: 99%