Association brain systems and visually guided movements in the cat

Батуев, А. С.; Cherenkova, L. V.; Yunatov, Yu. A.

doi:10.1016/0031-9384(83)90092-6

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…It should, however, be stressed that most studies (including this one) involved overtrained animals performing overlearned movements. The results could have been different if the testing had involved a completely new or newly learned motor skill (Batuev et al, 1983; Fabre & Buser, 1979, 1980). In any case, as far as well-learned motor acts are concerned, it would appear that the role of VL is restricted to the triggering phase of the movement.…”

Section: Discussionmentioning

confidence: 99%

“…Despite its strategic position, and the promising motor-related reactivity of the VL nucleus, bilateral lesions have been found in cats and primates to have remarkably little effect on the execution of well-learned motor acts (Batuev, Cherenkova, & Yunatov, 1983; Bénita, Condé, Dormont, & Schmied, 1979; Fabre & Buser, 1979, 1980; Moll & Kuypers, 1975; Ranish & Soechting, 1976). The only deficits seen were limited to a very transient increase of reaction time.…”

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confidence: 99%

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Visuomotor relearning after brain damage crucially depends on the integrity of the ventrolateral thalamic nucleus.

Fabre‐Thorpe¹,

Levesque²

1991

Behavioral Neuroscience

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The role of the ventrolateral thalamic nucleus (VL) has been analyzed in the phase of motor recovery that takes place when the execution of a previously learned movement has been perturbed by damage to another brain area. Cats were trained to perform a reaching movement toward a moving target-spot; they underwent bilateral brain lesions after performance had stabilized. A VL lesion induced a very transient increase of reaction time. The lesion of the main thalamic relay of the visual extrageniculate pathway (LP) severely disrupted accuracy and reaction time but was followed by full recovery. When both lesions were performed together, the deficits were similar to those induced by LP lesion alone, although they were more pronounced. However, the functional compensation was incomplete, and furthermore, the recovery of accuracy crucially depended on regular testing. These results support the involvement of VL in motor learning or relearning.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Visuomotor relearning after brain damage crucially depends on the integrity of the ventrolateral thalamic nucleus.

Fabre‐Thorpe¹,

Levesque²

1991

Behavioral Neuroscience

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“…10,11 Historical literature on thalamotomy suggests that a thalamic lesion will, at least temporarily, disrupt motor performance, and there is evidence for a nuanced role of the thalamus in motor control. For example, the ventrolateral nucleus (including the Vim) may be more involved in learning a task rather than completing it, 25,26 in integrating sensory information and transforming it into commands, [27][28][29][30] and in initiating movements. [31][32][33] The Kinarm tasks analyzed here do not have a substantial learning component, so this role of the Vim would not be captured in our data.…”

Section: Discussionmentioning

confidence: 99%

Limb Preference Changes after Focused‐Ultrasound Thalamotomy for Tremor

et al. 2023

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Background Magnetic resonance‐guided focused‐ultrasound (MRgFUS) thalamotomy is an effective treatment for essential and other tremors. It targets the ventrointermedius (Vim) nucleus, which is the thalamic relay in a proprioceptive pathway, and contains kinesthetic cells. Although MRgFUS thalamotomy reduces some risks associated with more invasive surgeries, it still has side effects, such as balance and gait disturbances; these may be caused by the lesion impacting proprioception. Objectives Our aim was to quantitatively measure the effects of MRgFUS on proprioception and limb use in essential tremor patients. We hypothesized that this thalamotomy alters proprioception, because the sensorimotor Vim thalamus is lesioned. Methods Proprioception was measured using the Kinarm exoskeleton robot in 18 patients. Data were collected pre‐operatively, and then 1 day, 3 months, and 1 year after surgery. Patients completed four tasks, assessing motor coordination and postural control, goal‐directed movement and bimanual planning, position sense, and kinesthesia. Results Immediately after surgery there were changes in posture speed (indicating tremor improvement), and in bimanual hand use, with the untreated limb being preferred. However, these measures returned to pre‐operative baseline over time. There were no changes in parameters related to proprioception. None of these measures correlated with lesion size or lesion‐overlap with the dentato‐rubro‐thalamic tract. Conclusions This is the first quantitative assessment of proprioception and limb preference following MRgFUS thalamotomy. Our results suggest that focused‐ultrasound lesioning of the Vim thalamus does not degrade proprioception but alters limb preference. This change may indicate a required “relearning” in the treated limb, because the effect is transient. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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“…In spite of their strategic anatomical position and their neuronal activity linked to movement, neither the lesions to MotTh nor RN induce severe motor impairments. VL lesions performed after learning are followed by remarkably little effect on motor function (Batuev, Cherenkova, & Yunatov, 1983; Bénita, Condé, Dormont, & Schmied, 1979; Bornschlegl & Asanuma, 1987; Canavan, Nixon, & Passingham, 1989; Fabre & Buser, 1979; Fabre & Buser, 1980; Fabre-Thorpe & Levesque, 1991b; Moll & Kuypers, 1975). Similar results are seen when the pyramidal tract is lesioned (Gorska & Sybirska, 1980; Laursen & Wiesendanger, 1967; Lawrence & Kuypers, 1968).…”

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Effect of pairing red nucleus and motor thalamic lesions on reaching toward moving targets in cats.

Lorincz¹,

Fabre‐Thorpe²

1997

Behavioral Neuroscience

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The small effects of bilateral lesions of motor thalamus on motor control and the transient deficits induced by bilateral kainic red nucleus (RN) lesions have been explained by a parallel competitive role of the cortico- and rubro-spinal pathways. Either pathway can take over motor control if the other is damaged. In this study the effect of bilateral and simultaneous lesions of both RN and motor thalamus was analyzed on cats overtrained to reach toward a moving target. After lesion, accuracy was impaired, movement onset was delayed, and movement execution was perturbed. However, postoperative retraining led to full recovery of the preoperative accuracy level although movement latency remained higher. The relative mildness of the long-lasting deficit after lesioning 2 main motor brain structures underlines the robustness of overlearned movements and widens the idea of parallelism in the motor system to other (subcortical?) pathways.

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Association brain systems and visually guided movements in the cat

Cited by 9 publications

References 17 publications

Visuomotor relearning after brain damage crucially depends on the integrity of the ventrolateral thalamic nucleus.

Visuomotor relearning after brain damage crucially depends on the integrity of the ventrolateral thalamic nucleus.

Limb Preference Changes after Focused‐Ultrasound Thalamotomy for Tremor

Effect of pairing red nucleus and motor thalamic lesions on reaching toward moving targets in cats.

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