Association immunohistochemical expression of Programmed Death-Ligand 1 (PD-L1) with degree Tumour Infiltrating Lymphocytes (TILs) as a prognosis factor in clear cell renal cell carcinoma and non clear renal cell carcinoma

Abstract

renal cell carcinoma (RCC) is a cancer originating from renal tubular epithelium and is known as a heterogeneous disease that includes different histological subtypes, CcRCC is the most frequent type and other renal epithelial malignancies as non ccRCC. The expression of PD-L1 in RCC can help to determine the prognosis of RCC patients who are known to be at high risk of having a poor prognosis.To assess the association between immunohistochemical expression of PD-L1 with the degree of TILS in patients with clear cell RCC and non clear RCC. PD-L1 immunohistochemical examination was performed on a fixed slide by using an H-score assessment of 26 samples of RCC and non clear RCC patients. Assessment of the degree of TILs is done on a slide with H&E staining. In our study found that Immunohistochemical expression of PD-L1 was found positive in 20 cases (76.9%) and negative in 6 cases (23.1%). There was no significant association between immunohistochemical expression of PD-L1 with histological types of clear cell RCC and non clear cell RCC. Immunohistochemical expression of PD-L1 is strongly correlated with the degree of TILs, where the higher the degree of PD-L1, the lower the degree of TILs in RCC clear cells and non clear RCC cells. Conclusion: The relationship of immunohistochemical expression of PD-L1 correlates strongly with the degree of TILs, so it can be considered for prognostic examination on RCC and may be considered to be a target therapy for RCC.