Association of 25(OH)D and PTH with Metabolic Syndrome and Its Traditional and Nontraditional Components

Kayaniyil, Sheena; Vieth, Reinhold; Harris, Stewart B.; Retnakaran, Ravi; Knight, Julia A.; Gerstein, Hertzel C.; Perkins, Bruce A.; Zinman, Bernard; Hanley, Anthony J.

doi:10.1210/jc.2010-1439

Cited by 108 publications

(94 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(2) What is the 'optimal' oral supplemental dose of vitamin D (taking into account all sources, including UVB exposure and dietary intake) in severely obese individuals, both before and after bariatric surgery? In conclusion, in this review the relationship between low circulating 25-hydroxyvitamin D and obesity was discussed, including potential mechanisms through which each might impact the other.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Obesity and these related issues contribute significantly to modern healthcare costs, morbidity and mortality. 4,5 Furthermore, weight loss is difficult to achieve and sustain, and consequently many individuals, especially those who already have significant co-morbidities, are turning to bariatric weight loss surgery as a way to effectively treat obesity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

View full text Add to dashboard Cite

Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In recent years, a growing body of evidence has demonstrated extraskeletal associations of both vitamin D (25-OH-D) (1-3) and parathyroid hormone (PTH) (4)(5)(6), with particular focus on their metabolic implications. Several studies have suggested that low levels of vitamin D may play a role in the development of type 2 diabetes mellitus (T2DM) (7)(8)(9).…”

mentioning

confidence: 99%

“…Furthermore, deterioration in b-cell function has been suggested as a pathophysiologic mechanism through which lower vitamin D may increase the risk of T2DM (10,11). Previous studies have also reported that increased PTH is associated with insulin resistance (12) and metabolic syndrome (4,13), and deterioration of insulin sensitivity and b-cell function has been described in hyperparathyroid states (14). Conversely, however, many investigators have questioned the association of vitamin D and PTH with glucose metabolism, particularly in light of several observational studies (13,(15)(16)(17)(18) and interventional trials (1,(19)(20)(21) that either have been negative or showed only modest beneficial effects of vitamin D supplementation on glucose homeostasis.…”

mentioning

confidence: 99%

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

et al. 2014

Self Cite

View full text Add to dashboard Cite

Previous studies have yielded conflicting findings on the relationship between low vitamin D (25-OH-D) and impaired glucose homeostasis. In this context, we hypothesized that combined assessment of 25-OH-D with its regulator parathyroid hormone (PTH) may be required for optimal evaluation of the impact of vitamin D status on glucose metabolism. Thus, we evaluated the prospective associations of 25-OH-D and PTH at 3 months postpartum with b-cell function (Insulin SecretionSensitivity Index-2 [ISSI-2]), insulin sensitivity (Matsuda index), and glycemia at 12 months postpartum in 494 women undergoing serial metabolic characterization. Notably, 32% of those with prediabetes/diabetes mellitus at 12 months postpartum had both vitamin D deficiency and PTH in the highest tertile at 3 months postpartum. On multiple-adjusted linear regression analyses, vitamin D deficiency/insufficiency with PTH in the highest tertile at 3 months independently predicted poorer b-cell function (P = 0.03) and insulin sensitivity (P = 0.01) and increased fasting (P = 0.03) and 2-h glucose (P = 0.002) at 12 months postpartum. In contrast, vitamin D deficiency/insufficiency with lower PTH did not predict these outcomes. In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of b-cell dysfunction, insulin resistance, and glycemia, highlighting the need for consideration of the PTH/25-OH-D axis when studying the impact of vitamin D status on glucose homeostasis.

show abstract

“…The prevalence of MS is remarkably high in CKD patients, being approximately 30% -65% for non-dialysis patients (6-8) and 47% -69% for dialysis patients (9-12). MS represents a global epidemic and it is clearly important to explore new, non-traditional risk factors.In the general population, MS has been positively associated with serum intact parathyroid hormone (iPTH) (13-15) and negatively with vitamin D status, as measured using 25-hydroxyvitamin D (25(oH)D) concentrations (16)(17)(18)(19)(20). Decreased vitamin D levels and elevated iPTH levels may play critical roles in the etiology of MS, either through an association with the Correspondence to: Jie Dong,…”

mentioning

confidence: 99%

Associations between Serum-Intact Parathyroid Hormone, Serum 25-Hydroxyvitamin D. Oral Vitamin D Analogs and Metabolic Syndrome in Peritoneal Dialysis Patients: A Multi-Center Cross-Sectional Study

et al. 2014

View full text Add to dashboard Cite

M etabolic syndrome (MS) consists of a cluster of metabolic and hemodynamic abnormalities. The components of MS such as abdominal obesity, high blood pressure, insulin resistance and dyslipidemia are risk factors for chronic kidney disease (CKD) (1,2), diabetes (3), cardiovascular disease (4) and high cardiovascular mortality (5). on the other hand, the components of MS develop early in CKD and are exacerbated during the progression to end-stage renal disease (eSRD) (6,7). The prevalence of MS is remarkably high in CKD patients, being approximately 30% -65% for non-dialysis patients (6-8) and 47% -69% for dialysis patients (9-12). MS represents a global epidemic and it is clearly important to explore new, non-traditional risk factors.In the general population, MS has been positively associated with serum intact parathyroid hormone (iPTH) (13-15) and negatively with vitamin D status, as measured using 25-hydroxyvitamin D (25(oH)D) concentrations (16)(17)(18)(19)(20). Decreased vitamin D levels and elevated iPTH levels may play critical roles in the etiology of MS, either through an association with the Correspondence to: Jie Dong,

show abstract

Association of 25(OH)D and PTH with Metabolic Syndrome and Its Traditional and Nontraditional Components

Abstract: Serum 25(OH)D, but not PTH, was significantly associated with MetS as well as a number of MetS components after multivariate adjustment. These results suggest that low 25(OH)D may play a role in the etiology of the MetS.

Cited by 108 publications

References 35 publications

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

Associations between Serum-Intact Parathyroid Hormone, Serum 25-Hydroxyvitamin D. Oral Vitamin D Analogs and Metabolic Syndrome in Peritoneal Dialysis Patients: A Multi-Center Cross-Sectional Study

Contact Info

Product

Resources

About