Association of 3-O-methylquercetin with β-cyclodextrin: complex preparation, characterization and ex vivo skin permeation studies

Caffeic Acid Loading Wound Dressing: Physicochemical and Biological Characterization

“…Additionally, the low gel-β release was a result of hampered caffeic acid dissociation from the CD cavity, since the complex formed with this CD was more stable than HPβCD [21]. This suggests that the sustained release was dependent on the CD ability to retain the caffeic acid in the network, as previously reported for CD-based hydrogels loaded with hydrophobic molecules [3,17,23,28].…”

“…Figure 3 present the FTIR spectra obtained from the gel-β and gel-HPβ with and without caffeic acid, and also, the network components alone (βCD, HPβCD, HPMC and caffeic acid). Both CD spectra show higher intensity on the following peaks (βCD/HPβCD): 3416/3447 cm -1 (O-H stretching), 2924 cm -1 (asymmetric vibrational stretching of C-H), 1645/1640 cm -1 (hydrogen interactions), 1157 cm -1 (C-O stretching) and 1029/1034 cm -1 (C-O-C) [3,16,17]. The HPMC spectrum showed a profile similar to the CD and the strong intensity peaks were identified: 3447 cm -1 (O-H stretching), 2924 cm -1 (asymmetric vibrational stretching of C-H), 1640 cm -1 (hydrogen interactions), 1115 and 1063 cm -1 (ether bond) [18,19].…”

“…All works stated that the IC, between the guest and the CDs, had a major contribution to the retention ability of CD-based hydrogels, which are in agreement with our results. Inter-actions between the guest molecule and HPMC were also referred, but with lower influence on the loading mechanism [3,17,23,24,25].…”

Quercetin and 3-O-methylquercetin in vitro skin layers permeation/retention from hydrogels: why only a methoxy group difference determines different behaviors?

“…Two polymers suit perfectly in this description: hydroxypropyl methylcellulose (HPMC) and chitosan (CS). The first one is a non‐ionic and hydrophilic cellulose derivative employed in several skin formulations containing phenolic compounds, such as coumestrol, formononetin and biochanin A and also, to 3‐ O MQ . Chitosan is a polymer with polycationic character.…”

Characterization and Functional Properties of Macela (Achyrocline satureioides) Extracts Obtained by Supercritical Fluid Extraction Using Mixtures of CO2 Plus Ethanol

“…Most of the properties of A. satureioides extracts have been attributed to the antioxidant properties of the flavonoids. In this context, a recent study, considering previously described activities indicating that the topical delivery of 3-O-methylquercetin might have therapeutic application for the treatment of Herpes Simplex Virus infections, evaluated the possibility of enhancing its aqueous solubility, and, hence, its bioavailability, through the formation of a complex with β-cyclodextrin (Schwingel et al 2008). SFE has been extensively studied as an alternative method to obtain these substances from vegetable matrices.…”