Association of −344/T/C aldosterone synthase polymorphism (CYP11B2) with left ventricular structure and humoral parameters in young normotensive men

Abstract

In agreement with previous studies, we found that the TT genotype of T-344C polymorphism of aldosterone synthase gene was associated with significantly higher levels of PRA in normotensive men. In subjects with high PRA, the TT genotype was associated with higher values of the LVMI.

Association of the C−344T aldosterone synthase gene variant with essential hypertension: a meta-analysis

“…In the same 13 studies where data about DABP were available in the same conditions described above [9,21,24,28,30,36,[39][40][41]47,48,50,55] no significant association with the variant was found (Table 3). Besides, there was significant heterogeneity (P < 0.01), mainly between studies including Caucasians.…”

“…Twenty-seven studies included Caucasian subjects [4,6,8,12,21,23,26,[28][29][30]33,34,38,[40][41][42][44][45][46]48,[50][51][52][54][55][56][57], two studies included Finnish population [36,47], two studies included Chinese subjects [31,43], nine involved Japanese individuals [7,9,10,13,22,24,35,37,49], one study included African American and White-Latino subjects [32], one study included Himalayan subjects [39] and one study included African or Afro-Caribbean people [45].…”

“…Table 1 Summary estimates for odds ratios (effect), the corresponding 95% confidence interval (CI) limits (lower and upper) and significance (P value) were estimated by fixed and random effects meta-regression analysis for hypertension between the two groups according to the C-344T CYP11B2 variant (homozygous TT and CC) according to ethnicity confounding variable in the analysis [6,12,13,22,33,35,37,[42][43][44]51,56]. Consequently, data about SABP were available in 13 studies encompassing 1775 individuals [9,21,24,28,30,36,[39][40][41]47,48,50,55] and no association with the CYP11B2 CÀ344T variant was found by either fixed or random models (Table 2). There was significant heterogeneity amongst the reports, P < 0.005, particularly in Caucasian populations.…”

“…Twenty-four studies were population-based [6,8,12,13,22,26,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] and 18 were hospital-based studies [4,7,9,10,21,23,24,[46][47][48][49][50][51][52][53][54][55][56].…”

Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

“…7 Then a large number of studies seeking to link the −344C/T polymorphism to LVH were conducted in individuals of different races and ethnic groups using different statistical models in various left ventricular structure and function indicators, but the results have often been unreproducible. [8][9][10][11][12][13] A meta-analysis regarding the relationship between −344C/T and left ventricular size was published in 2008. This meta-analysis covered 14 studies that were performed mainly on Europeans, but in recent years, many studies covering other ethnic groups, especially Asians, have been published.…”