Association of a novel polymorphism in the bovine PPARGC1A gene with growth, slaughter and meat quality traits in Brangus steers

Soria, Laura; Corva, P. M.; Sica, Andrea Branda; Villarreal, E. L.; Melucci, L. M.; Mezzadra, C. A.; Mazzucco, Juliana Papaleo; Macedo, GS; Silvestro, C.; Schor, Alejandro; Miquel, M. C.

doi:10.1016/j.mcp.2009.07.007

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…In dairy cattle, a significant association between an SNP in intron 9 of PPARGC1A and milk fat yield was observed by Weikard et al (2005). Soria et al (2009) studied an SNP in exon 8 of the same gene and could not find a significant association between either final live body weight, gain in BFT, kidney fat weight, kidney fat percentage, Warner-Bratzler shear force at 7 days postmortem, intramuscular fat percentage or meat color, and the SNP studied. In accordance with results presented in the current study, Tizioto et al (2012) reported no association between the same SNP evaluated in this work, and BFT and REA in a Nellore cattle population.…”

Section: Discussionmentioning

confidence: 98%

“…Generally, candidate genes are selected based on their physiological or biochemical function and position. Some genes mapped to these chromosomes, such as leptin; peroxisome proliferative active receptor gamma coactivator 1A (PPARG-C1A); proteasome 26S subunit ATPase 1 (PSMC1); corticotropin releasing hormone (CRH); and fatty acid binding protein 4 (FABP4), have been suggested as candidates that may influence production traits (Buchanan et al, 2002;Liefers et al, 2003;Kononoff et al, 2005;Wibowo et al, 2007;Cho et al, 2008;Guo et al, 2008a;Soria et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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ABSTRACT. Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal's life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which influence BFT and REA in Canchim cattle, a composite beef breed (5/8 Charolais + 3/8 Zebu). BFT and REA phenotypic records were obtained by ultrasound measurements from 18-month-old animals. All SNP markers were genotyped by restriction fragment length polymorphismpolymerase chain reaction. Restricted maximum likelihood analysis revealed that the non-synonymous SNP located in exon 2 of the FABP4 gene has an additive effect on BFT (P ≤ 0.05). Significant allele substitution 16668©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16667-16674 (2015) G. Veneroni-Gouveia et al. effects showed that the substitution of G by A may lead to a decrease of 0.1055 mm in mean BFT. This information can be used for inclusion of this trait-associated marker in commercial SNP panels.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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“…These authors have found an association between an SNP located in intron 9 of bovine PPARGC1A and milk production traits. Soria et al (2009) have identified 2 SNPs in exon 8 of bovine PPARGC1A but found no association with production traits in beef cattle. For this population of Nelore, we also found no significant association between PPARGC1A and any of the traits studied.…”

Section: Resultsmentioning

confidence: 99%

Candidate genes for production traits in Nelore beef cattle

Tizioto

Meirelles²,

Tulio³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Meat quality is an important trait for the beef industry. Backfat thickness, ribeye area, and shear force are traits measured late in life, and the investigation of molecular markers associated with these traits can help breeding programs. In cattle, some polymorphisms have been related to production traits. Thus, the purpose of this study was to assess the presence of polymorphisms in the candidate genes insulinlike growth factor 1 (IGF1), fatty acid-binding protein 4 (FABP4), and peroxisome proliferative active receptor gamma coactivator 1 A (PPARGC1A) and associate them with production traits in reference families of Nelore cattle. We used 270 steers descendent from 20 sires that were chosen to represent variability in this breed. The investigation of marker effects on the traits was performed using a mixed model under the restricted maximum likelihood method. A significant allele substitution effect was found for IGF1 and yearling weight (P ≤ 0.017). 4139©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (4): 4138-4144 (2012) Candidate genes in NeloreThe mean allele substitution effect was 6.9 kg, with the 229 allele associated with reduced yearling weight in this Nelore population.

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“…The most common polymorphism c.1892-19T>C in bovine PPARGC1A intron 9 was studied for the associations with milk production and milk-fat composition traits (Weikard et al, 2005; Khatib et al, 2007; Komisarek and Dorynek, 2009; Schennink et al, 2009; Kowalewska-Luczak et al, 2011). Several other polymorphisms in the bovine PPARGC1A gene have been identified and studied for the association with meat quality and carcass phenotypes (Soria et al, 2009; Ryu et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the Promoter Region of the Chinese Bovine <italic>PPARGC1A</italic> Gene

Liu

et al. 2013

Asian Australas. J. Anim. Sci

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The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level.

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Association of a novel polymorphism in the bovine PPARGC1A gene with growth, slaughter and meat quality traits in Brangus steers

Cited by 16 publications

References 23 publications

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for production traits in Nelore beef cattle

Polymorphisms in the Promoter Region of the Chinese Bovine <italic>PPARGC1A</italic> Gene

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Association of a novel polymorphism in the bovine PPARGC1A gene with growth, slaughter and meat quality traits in Brangus steers

Cited by 16 publications

References 23 publications

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for production traits in Nelore beef cattle

Polymorphisms in the Promoter Region of the Chinese Bovine &lt;italic&gt;PPARGC1A&lt;/italic&gt; Gene

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Polymorphisms in the Promoter Region of the Chinese Bovine <italic>PPARGC1A</italic> Gene