Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Bai, Rongpan; Weng, Yu; Su, Liling; Jin, Mingjuan; Xu, Zhengping; Lu, Liqin; Chen, Guang-Di

doi:10.7314/apjcp.2014.15.23.10107

Cited by 12 publications

(7 citation statements)

References 41 publications

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“…When stratified by the cancer type, our data was consistent with previous meta-analysis reports that the [G] allele of rs895819 was associated with decreased risk in breast cancer for all population and Caucasians, but not Asians [ 29 , 33 ]. For colorectal cancer, the study by Liu et al, pooling seven studies with 2,230 cases and 2,775 controls provided a moderate evidence for the association between rs895819 and increased risk of colorectal cancer under multiple genetic models for all population and Asians, but not Caucasians [ 28 ].…”

Section: Discussionsupporting

confidence: 91%

“…Based on 17 case-control studies with 7,813 cases and 9,602 controls, our previous meta-analysis did not suggest any association between rs895819 and cancer susceptibility, while rs895819 was associated with a reduced cancer risk in heterozygous, dominant or additive model in Caucasians but not in Asians [ 33 ]. By pooling 19 studies (17 articles) involving 7,800 cases and 9,060 controls, a recent study by Feng et al, failed to find any associations between rs895819 polymorphism and cancer risk, while statistically significantly reduced cancer risks were found among Asians for dominant contrast and a subtly decreased risk was observed in the Caucasian population for heterozygous or additive contrast [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Distinct effects of rs895819 on risk of different cancers: an update meta-analysis

Chen

Fang

et al. 2017

Oncotarget

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Previous studies have indicated an association between the genetic variant in pre-miR-27a rs895819 with A->G transition and cancer risk; however, the results remain inconsistent and somehow conflicting in different cancers. Therefore, to obtain a more reliable conclusion, we performed an update meta-analysis by searching PubMed database or other databases. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to evaluate cancer risk. A total of 34 case-control studies involving 15,388 cases and 18,704 controls were included. The results showed that rs895819 was associated with an increased cancer risk (GG vs. AA/AG: OR = 1.15, 95% CI = 1.02–1.29). Furthermore, stratification analyses revealed an association of rs895819 with increased cancer risk among Asians (GG vs. AA: OR = 1.17, 95% CI = 1.01–1.36; GG vs. AA/AG: OR = 1.18, 95% CI = 1.03–1.35), but not Caucasians. Interestingly, the [G] allele of rs895819 was significantly associated with decreased risk of breast cancer (G vs. A: OR = 0.91, 95% CI = 0.86–0.97). However, rs895819 was associated with increased risk of colorectal cancer (GG vs. AA: OR = 1.56, 95% CI = 1.31–1.85; GG vs. AA/AG: OR = 1.53, 95% CI = 1.30–1.79; G vs. A: OR = 1.19, 95% CI = 1.09–1.30) and lung cancer (GG vs. AA/AG: OR = 1.43, 95% CI = 1.00–2.04). In addition, no association was found between rs895819 and risk of gastric cancer or esophageal cancer. In conclusion, our findings suggest distinct effects of rs895819 on risk of different cancers, and future well-designed studies with large samples are required to further validate our results.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Distinct effects of rs895819 on risk of different cancers: an update meta-analysis

Chen

Fang

et al. 2017

Oncotarget

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“…With respect to the meta-analyses, the first, which included 4 studies, concluded that subjects carrying the rs895819 G allele showed reduced BC risk [ 65 ]. The meta-analysis published by Bai et al [ 66 ] found a significant association between rs895819 allele G and reduced BC risk in Caucasians, but not in Asians. A protective effect of rs895819 allele G was seen in the younger BC cases and in the subgroup of unilateral BC cases.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population

et al. 2016

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BackgroundMicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide polymorphisms (SNP) can alter miRNA expression, resulting in diverse functional consequences. Previous studies have examined the association of miRNA SNPs with breast cancer (BC) susceptibility. The contribution of miRNA gene variants to BC susceptibility in South American women had been unexplored. Our study evaluated the association of the SNPs rs895819 in pre-miR27a, rs11614913 in pre-miR-196a2, rs6505162 in pre-miR-423, rs4919510 in miR-608, and rs2682818 in pre-mir-618 with familial BC and early-onset non-familial BC in non-carriers of BRCA1/2 mutations from a South American population.ResultsWe evaluated the association of five SNPs with BC risk in 440 cases and 807 controls. Our data do not support an association of rs11614913:C > T and rs4919510:C > G with BC risk. The rs6505162:C > A was significantly associated with increased risk of familial BC in persons with a strong family history of BC (OR = 1.7 [95 % CI 1.0–2.0] p = 0.05). The rs2682818:C > A genotype C/A is associated with an increased BC risk in non-familial early-onset BC. For the rs895819:A > G polymorphism, the genotype G/G is significantly associated with reduced BC risk in families with a moderate history of BC (OR = 0.3 [95 % CI 0.1–0.8] p = 0.01).ConclusionsThe contribution of variant miRNA genes to BC in South American women had been unexplored. Our findings support the following conclusions: a) rs6505162:C > A in pre-miR-423 increases risk of familial BC in families with a strong history of BC; b) the C/A genotype at rs2682818:C > A (pre-miR-618) increases BC risk in non-familial early-onset BC; and c) the G/G genotype at rs895819:A > G (miR-27a) reduces BC risk in families with a moderate history of BC.

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“…Previous results regarding association of genetic variant rs895819 with cancer risk are contradictory (Bai et al, 2014). Several lines of evidence suggest that minor allele of this variant confers the increased risk of developing specific types of cancer, while some case-control studies supported the protective effect of the same allele.…”

Section: Primer Type Sequencementioning

confidence: 95%

Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

Nikolic

Savić‐Pavićević

Vučić

et al. 2015

Experimental and Molecular Pathology

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Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

Cited by 12 publications

References 41 publications

Distinct effects of rs895819 on risk of different cancers: an update meta-analysis

Distinct effects of rs895819 on risk of different cancers: an update meta-analysis

Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population

Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population

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