Association of A1C Levels With Vitamin D Status in U.S. Adults

Kositsawat, Jatupol; Freeman, Vincent L.; Gerber, Ben S.; Geraci, Stephen A.

doi:10.2337/dc09-2150

Cited by 127 publications

(100 citation statements)

References 12 publications

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“…Interestingly, in our patients, hypovitaminosis D was not associated with worse glycaemic control (HbA1c) or lower testosterone levels as demonstrated by other authors (Kositsawat et al, 2010;Foresta et al, 2011;Ahn et al, 2013;Manickam et al, 2013). The lack of this association should be attributed to the small number of studied subjects.…”

Section: Discussionsupporting

confidence: 60%

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

et al. 2015

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SUMMARYLower urinary tract symptoms (LUTS) may develop more commonly in men with type 2 diabetes mellitus (T2DM). LUTS are often associated with benign prostate hyperplasia (BPH), in general population. An association between LUTS and hypovitaminosis D, and between hypovitaminosis D and type 2 diabetes (T2DM), has also been suggested. Thus, we aim to evaluate possible relationships between hypovitaminosis D, LUTS, and BPH in T2DM men. In this prospective observational study, 67 T2DM males (57.9 AE 9.28 years) underwent medical history collection, International Prostate Symptom Score (IPSS) questionnaire, that allows the identification and grading of LUTS, physical examination, biochemical/hormonal blood tests (fasting plasma glucose, glycated haemoglobin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, creatinine, LH, total testosterone, estradiol (E 2 ), 25-OH-vitamin D, PTH, calcium, phosphate, and PSA) and ultrasound transrectal prostate examination. Subdividing patients into three groups, on the base of 25-OH-vitamin D concentration (sufficiency ≥50; insufficiency >25 < 50; and deficiency ≤25 nM), a significant progressive increase of prostate volume (p = 0.037), IPSS score (p = 0.019), diastolic blood pressure (p = 0.018), and a significant decrease in HDL cholesterol (p = 0.038) were observed. 25-OH-Vitamin D levels were inversely correlated with both IPSS (R = À0.333; p = 0.006) and prostate volume (R = À0.311; p = 0.011). At multivariate analysis, hypovitaminosis D remained an independent predictor of both IPSS and prostate volume. In conclusion, we showed, for the first time, an association between 25-OH-vitamin D deficiency, LUTS, and BPH in T2DM men.

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Section: Discussionsupporting

confidence: 60%

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

et al. 2015

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“…Indeed, 13 observational studies and 18 trials on cardiometabolic outcomes failed to show a clinically significant effect of vitamin D supplementation (14). In the National Health and Nutrition Examination Survey, however, low levels of vitamin D were associated with higher A1c values in a large non-diabetic adult population (15). Low levels of vitamin D have also been shown to be associated with insulin resistance (16,17) and MetS (18).…”

Section: Discussionmentioning

confidence: 99%

Serum calcium level is associated with metabolic syndrome in the general population: FIN-D2D study

Saltevo

Niskanen

Kautiainen

et al. 2011

European Journal of Endocrinology

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Background: The aim of this cross-sectional study was to examine the association between serum calcium and the components of metabolic syndrome (MetS). Methods: As a part of the national prevention program of diabetes in Finland (FIN-D2D), a randomly selected study population of 4500 middle-aged men and women were recruited from three central hospital district areas. Anthropometric measurements were performed by a trained nurse. An oral glucose tolerance test was performed and serum calcium and lipids were measured. We assessed current medications, physical activity, smoking, alcohol consumption, calcium intake, and vitamin D intake. The MetS was defined according to the criteria of the updated National Education Program. The study population consisted of 2896 individuals: 1396 men (62% of invited individuals) and 1500 women (66.7% of invited individuals). Results: The mean age was 60.3G8.3 years in men and 59.8G8.5 years in women. The prevalence of MetS was 50.7% in women and 55.8% in men. The prevalence of MetS and its components, except high-density lipoprotein (HDL)-cholesterol, increased linearly with increasing serum calcium (P!0.001), even after adjustment for age, physical activity, alcohol, vitamin D intake, calcium intake, and smoking. The threshold value for serum calcium for MetS was 2.50 mmol/l in this population. The association of MetS with total serum calcium was similar even after exclusion of patients treated with hypertensive drugs. The drug treatments for hypertension, dyslipidemia, and diabetes increased in a similar pattern. Conclusions: Serum calcium level is associated with MetS and its components, except HDL-cholesterol.

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“…The decreased bone mineral density associated with T1D may be due to a variety of factors, including earlier age at onset of diabetes [3] and coexisting conditions such as celiac disease [4] or thyroid disease [5]. Similarly, low serum 25-hydroxyvitamin D levels are associated with poor bone mineral density, and patients with T1D may have low 25-hydroxyvitamin D levels, which may be most significant in patients with poor diabetes control [6].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Abnormalities: More Common in US Children with T1D than in Healthy Children

Sheedy¹,

Xu²,

Saville³

et al. 2014

JDM

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Background: Pediatric patients with type 1 diabetes (T1D) have increased risk for low bone mineral density, which may be due in part to low 25-hydroxyvitamin D levels. Vitamin D levels are influenced by sunlight exposure and thus display geographical variation. We hypothesize that the prevalence of 25-hydroxyvitamin D deficiency (<20 ng/mL) and insufficiency (20 -29 ng/mL) in children with T1D living in the United States is higher than in healthy children and that diabetes duration, HbA1c, and insulin dose/kg are inversely associated with 25-hydroxyvitamin D levels. Methods: Medical records of patients with T1D being followed in Tennessee were reviewed for demographics, medical information, and 25-hydroxyvitamin D levels during the previous 2 years. Control subjects were obtained from a de-identified database of healthy pediatric subjects living in a similar geographical area. Chi squared tests and multivariable linear regression were performed. Results: Children and adolescents with T1D (n = 276; median age 14 years) have a significantly higher percentage of vitamin D deficiency and insufficiency compared with healthy pediatric controls (n = 100; median age 11.2 years) (68% versus 44%; p < 0.001). The median 25-hydroxyvitamin D level is 24 ng/mL versus 31 ng/mL, respectively. After adjusting for age, race, gender, UV light exposure, BMI, and multivitamin supplementation, children and adolescents with T1D have a serum 25-hydroxyvitamin D level 6.7 ng/mL lower than the control population [CI (4.11, 9.21), p < 0.0001]. Within the T1D population, there is no clear association between diabetes duration, HbA1c, or insulin dose/kg and 25-hydroxyvitamin D levels. Conclusions: There is an increased prevalence of 25-hydroxyvitamin D deficiency and insufficiency in US. children with T1D compared with geographically similar children without diabetes. Further research is needed to determine whether decreased serum 25-hydroxyvitamin D can be alleviated via dietary or behavioral modifications in this population. C. Sheedy et al.325

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Association of A1C Levels With Vitamin D Status in U.S. Adults

Cited by 127 publications

References 12 publications

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes

Serum calcium level is associated with metabolic syndrome in the general population: FIN-D2D study

Vitamin D Abnormalities: More Common in US Children with T1D than in Healthy Children

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