Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort

Guillén, Rebeca; Otero, Fátima; Mosquera, Alejandro; Vázquez-Mosquera, M.E.; Rego‐Pérez, Ignacio; Blanco, Francisco J.; Fernández, José Luis Fernández

doi:10.1038/s41598-021-95326-7

Cited by 6 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteoarthritis (OA), the most common reason for joint disease, is an age-related joint degenerative disease and the leading cause of laboral disability in older adults ( Guillen et al, 2021 ). The main clinical characteristics of patients with OA include pain, swelling, brief morning stiffness, and functional limitations.…”

Section: Introductionmentioning

confidence: 99%

HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

2022

View full text Add to dashboard Cite

Osteoarthritis is a common age-related joint degenerative disease. Pain, swelling, brief morning stiffness, and functional limitations are its main characteristics. There are still no well-established strategies to cure osteoarthritis. Therefore, better clarification of mechanisms associated with the onset and progression of osteoarthritis is critical to provide a theoretical basis for the establishment of novel preventive and therapeutic strategies. Chondrocytes exist in a hypoxic environment, and HIF-1α plays a vital role in regulating hypoxic response. HIF-1α responds to cellular oxygenation decreases in tissue regulating survival and growth arrest of chondrocytes. The activation of HIF-1α could regulate autophagy and apoptosis of chondrocytes, decrease inflammatory cytokine synthesis, and regulate the chondrocyte extracellular matrix environment. Moreover, it could maintain the chondrogenic phenotype that regulates glycolysis and the mitochondrial function of osteoarthritis, resulting in a denser collagen matrix that delays cartilage degradation. Thus, HIF-1α is likely to be a crucial therapeutic target for osteoarthritis via regulating chondrocyte inflammation and metabolism. In this review, we summarize the mechanism of hypoxia in the pathogenic mechanisms of osteoarthritis, and focus on a series of therapeutic treatments targeting HIF-1α for osteoarthritis. Further clarification of the regulatory mechanisms of HIF-1α in osteoarthritis may provide more useful clues to developing novel osteoarthritis treatment strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

2022

View full text Add to dashboard Cite

show abstract

“…indicates an association between telomere loss in leukocytes and development of incident radiographic knee OA. 39 …”

Section: Discussionmentioning

confidence: 99%

Sex‐specific differences in telomere length of patients with primary knee osteoarthritis

Kuszel,

Trzeciak,

Begier‐Krasinska

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

Accelerated telomere shortening is associated with age‐related diseases, including osteoarthritis (OA). We aimed to determine the relative telomere length (TL) in leukocytes and cartilage of patients with primary knee OA and to investigate factors that may affect TL in OA. Relative TL measurements were performed using qPCR in leukocytes of 612 individuals (310 patients with primary knee OA undergoing total knee arthroplasty (TKA) and 302 unaffected controls). We also analysed cartilage in 57 of the 310 OA patients, measuring relative TL in severely affected and less affected (control) cartilage collected from the same knee. Cartilage TLs were compared to leukocyte TLs in all 57 patients. A significant sex‐by‐disease‐status interaction was found in regard to relative TL. Controlling for age, the average difference of leukocyte TL between female OA patients versus female controls was 0.217 units greater than that between male OA patients versus male controls (95% CI; [0.014, 0.421]). Relative TL comparison of severely and less affected cartilage samples from the same joint showed attrition of telomeres corresponding to disease severity (0.345 mean TL difference with 95% CI of [0.151, 0.539]) in the joint. We also noted that both severely and less affected cartilage had shorter telomeres than leukocytes collected from the same patient. Severe and moderate pain in OA patients was associated with shorter TL in leukocytes, but there was no association with depression or smoking in leukocytes and cartilage. Our study indicates that sex is an important factor in OA contributing to leukocyte and cartilage TL and that pain in OA shows an inverse association only with leukocyte TL.

show abstract

“…Osteoarthritis (OA) is a chronic degenerative disease causing articular cartilage breakdown, leading to significant mobility impairment, pain, and reduced activities of daily living (ADL) in the elderly [ 1 , 2 ]. Its prevalence is expected to continue to rise due to increasing life expectancies [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Cartilage Metabolism in Rats through a Novel Thermal Stimulation Technique with Photosensitizers

Cha,

Nakagawa,

Arai

et al. 2024

IJMS

View full text Add to dashboard Cite

Although the moderate thermal stimulation of articular cartilage exerts chondroprotective effects, it is difficult to effectively heat deep articular cartilage with conventional methods. Photosensitizers increase the ambient temperature using near-infrared (NIR) radiation, which has high tissue permeability. We hypothesized that the intra-articular administration of photosensitizers and NIR irradiation would exert a greater heating effect on articular cartilage. We aimed to evaluate the heating effect of this method on cultured chondrocytes and rat knee cartilage. In vitro, we irradiated a photosensitizer-containing medium with NIR and measured changes in the medium temperature, cytotoxicity, and gene expression of heat shock protein (HSP) 70 and aggrecan (ACAN). In vivo, the knee joints of rats treated with photosensitizers were irradiated with NIR, and changes in intra-articular temperature and gene expression were measured, alongside histological analysis. The results showed that the medium and intra-articular temperature were raised to approximately 40 °C with no apparent disruption to articular cartilage or the immunohistochemically enhanced staining of HSP70 in chondrocytes. The gene expression of HSP70 and ACAN was increased in both cultured and articular cartilage. In summary, this method can safely heat joints and enhance cartilage metabolism by inducing HSP70 expression in articular cartilage. It presents a new hyperthermia therapy with effective cartilage protection.

show abstract

Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort

Cited by 6 publications

References 15 publications

HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

Sex‐specific differences in telomere length of patients with primary knee osteoarthritis

Enhancing Cartilage Metabolism in Rats through a Novel Thermal Stimulation Technique with Photosensitizers

Contact Info

Product

Resources

About