Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study

Zadjali, Fahad; Al-Yahyaee, Saeed; Hassan, Mohammed O.; Albarwani, Sulayma; Bayoumi, Riad

doi:10.1016/j.gene.2013.06.057

Cited by 33 publications

(33 citation statements)

References 55 publications

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“…Studies in Omani (Zadjali et al, 2013), Taiwanese (Lin et al, 2012). North Indians (Gupta et al, 2010), Chinese (Tso et al, 2006), European (Gable et al, 2007), Hispanic and African-American populations failed to exhibit significant relationship with the investigated SNP.…”

Section: Discussionmentioning

confidence: 87%

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Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

Kaftan

Hussain

2015

Gene

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Section: Discussionmentioning

confidence: 87%

“…Zadjali et al (2013) and Sun et al (2008) have studied this relationship and found no association. So how does adiponectin affect HDL levels?…”

Section: Discussionmentioning

confidence: 98%

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

Kaftan

Hussain

2015

Gene

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“…Regarding the inverse relationship of HDL levels with rs266729 polymorphism and to our knowledge, it is the first investigation at which such observation was reported, Zadjali et al 2013, andSun et al 2008, have studied this relationship and found no association. So how does adiponectin affect HDL levels?…”

Section: Discussion:-mentioning

confidence: 78%

ASSOCIATION OF ADIPONECTIN GENE POLYMORPHISM rs266729 WITH ADIPONECTIN LEVELS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT CVD. IN AL-NAJAF GOVERNORATE, IRAQ.

Ismail¹,

Hussain²,

Mohammad³

2016

IJAR

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Background:-Cardiovascular diseases are a group of disorders of the heart and blood vessels. Adiponectin is an adipocyte-secreted protein with insulinsensitizing and anti-atherogenic properties. Many studies demonstrated that polymorphisms within the adiponectin gene could be associated in T2DM with and without CVD.Methods:-A case-control study was conducted to find the association between SNP rs266729 in T2DM with and without CVD in Al-Najaf Governorate, Iraq. The study included 203 T2DM patients with CVD randomly selected based on World Health Organization (WHO) guideline and 133 T2DM patients without CVD as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme. Multinomial logistic regression was applied to compare the proportions of genotypes and alleles. The odds ratio for risk of developing CVD in T2DM was calculated with and without adjustment for age, sex, and BMI.Results:-The frequency of G allele of rs266729 (C/G) polymorphism was significantly lower (p=0.0001) in T2DM with CVD (27.3%) compared to that without CVD (33.08%). The homozygous genotype (GG) significantly (0R=7.570, CI 95%(1.597-32.530), P= 0.011) increased the risk of T2DM with CVD seven folds with respect to those of the wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly [0R=2.818,CI 95%(1.00-12.596), P= 0.050] raised the risk of T2DM with CVD by two folds. Homozygous and heterozygous genotypes of rs266729 polymorphism exhibited significant association with decreased adiponectin levels (P= 0.08).Conclusion:-Adiponectin gene polymorphism rs266729 is involved in the pathogenesis of T2DM with CVD. In addition this SNP may play a role in the development of cardiovascular diseases and metabolic syndrome by affecting HDL and adiponectin levels.Copy Right, IJAR, 2016,. All rights reserved.

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“…Although studies on ADIPOQ genetic variations in Arab populations are still limited and there are no metaanalyses showing the frequency of Arabs carrying variants of the ADIPOQ gene, several researchers have reported that a statistically significant number of Arab obese diabetic patients carry variants of the ADIPOQ gene (73,77).…”

mentioning

confidence: 99%

“…Of interest is that one of the variants that showed a strong association with T2DM was the same variant (rs266729) found in the Jordanian study (73,78). A recent cross-sectional analysis examined the association of genetic variants of the ADIPOQ gene with obesity, insulin resistance, dyslipidaemia and hypertension in 328 people from one extended Omani family living in an area where first-cousin marriages represented 50% of all marriages (77). The prevalence of obesity and diabetes were 17% and 27% respectively.…”

mentioning

confidence: 99%

Obesity-linked diabetes in the Arab world: a review

Abuyassin¹,

Laher²

2015

Easter Mediterr Health J

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Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study

Cited by 33 publications

References 55 publications

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

ASSOCIATION OF ADIPONECTIN GENE POLYMORPHISM rs266729 WITH ADIPONECTIN LEVELS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT CVD. IN AL-NAJAF GOVERNORATE, IRAQ.

Obesity-linked diabetes in the Arab world: a review

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