Association of Adrenoreactivity With the Stage of Chronic Heart Failure in Patients With Previous Myocardial Infarction

Александренко, В. А.; Rebrova, Т. Yu.; Afanasiev, S. A.; Гарганеева, А. А.

doi:10.29001/2073-8552-2019-34-2-79-83

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Преимуществом данного метода, определяющим его доступность для реальной клинической практики, является простота использования, высокая информативность и низкая стоимость расходных материалов. В настоящее время накоплены данные об особенностях β-АРМэ у больных после инфаркта миокарда (ИМ) [8][9][10], у пациентов с хронической сердечной недостаточностью (СН) [11], а также у больных РАГ [12]. Тем не менее сведения о степени выраженности симпатической гиперактивации на основе β-АРМэ в селективной группе больных с рфАГ как крайнего фенотипа неконтролируемой АГ до настоящего времени отсутствуют.…”

Section: Beta-adrenergic Reactivity Of Erythrocyte Membranes In Vario...unclassified

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

Manukyan,

Falkovskaya,

Mordovin

et al. 2024

Russ J Cardiol

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Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ damage.Material and methods. The cross-sectional comparative study included 78 patients with uncontrolled hypertension (mean age, 57,4±9,3 years (33 men)) with 24-hour blood pressure (BP) (systolic/diastolic) of 160,0±18,8/88,1±17,3 mm Hg. Thirty-nine (50%) patients had type 2 diabetes (T2D). At baseline, patients were divided into 2 groups depending on the phenotype of uncontrolled hypertension. The first group consisted of patients with rfHTN (n=26 (33,3%)), the second — with rHTN (uncontrolled BP with 3-4 agent therapy) (n=52 (66,7%)). In all patients, office and mean 24-hour blood pressure, EM β-adrenergic reactivity and target organ damage were assessed.Results. The compared groups did not differ in sex and age composition, prevalence of T2D and basic clinical data. However, despite comparable levels of office and mean 24-hour blood pressure, the incidence of left ventricular (LV) hypertrophy according to echocardiography in rfHTN was significantly higher than in rHTN (96,2% vs 76,9%, p=0,027, respectively). An increase in EM β-adrenergic reactivity (>20 conventional units) was documented in 87,1% of patients in the general group. Moreover, the mean EM β-adrenergic reactivity in the rfHTN group was significantly higher than in the rHTN group (51,5±18,7 vs 39,3±18,2, p=0,008). According to ROC analysis, the threshold value of EM β-adrenergic reactivity corresponding to rfHTN was ≥44,8 conventional units (sensitivity — 69,2%, specificity — 64,5%, area under the ROC curve — 0,687). The mean EM β-adrenergic reactivity in the rfHTN group did not have a direct relationship with the LV mass index, but correlated with increased pulse pressure.Conclusion. RfHTN is associated with higher EM β-adrenergic reactivity values than in patients with rHTN, which may indirectly confirm more pronounced sympathetic activity and explain the higher prevalence of LVH, realized through an increase in vascular stiffness and load on the LV.

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Section: Beta-adrenergic Reactivity Of Erythrocyte Membranes In Vario...unclassified

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

Manukyan,

Falkovskaya,

Mordovin

et al. 2024

Russ J Cardiol

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“…Вместе с тем, были установлены существенные различия в носительстве генотипов и аллелей полиморфизма Arg389Gly гена ADRB1 среди пациентов с нормальными и повышенными пациентов с инфарктом миокарда, отражая тем самым повышенную активность САС [9,12]. На сегодняшний день в доступной литературе отсутствуют убедительные доказательства наличия ассоциации гена бета-1-адренорецепторов с показателями бета-адренореактивности мембран эритроцитов, в частности у пациентов с ИМ.…”

Section: материалы и методыunclassified

Association of beta-adrenergic reactivity index of erythrocyte membranes in myocardial infarction with genetic features of the beta-adrenoreceptor apparatus

Гарганеева

Александренко

Кужелева

et al. 2021

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Objective: To study the association of beta-adrenergic reactivity index of erythrocyte membranes with polymorphisms of the beta-1-adrenergic receptor gene ADRB1 (Ser49Gly and Arg389Gly).Material and methods: the study included 62 patients with myocardial infarction (MI) — 49 men (median age of 58.0 (47.5; 64.5) years) and 13 women (median age of 76.0 (61.5; 81.0) years). All patients underwent analysis of beta-adrenoreactivity of erythrocyte membranes using the BETA-ARM AGAT reagent kit within the first 6 hours from the onset of MI. The patients were divided into 2 groups depending on the value of the beta-adrenergic reactivity index (β-ARM). The first group (n = 11) included patients with a normal P-ARM level (from 2 to 20 conventional units). The second group (n = 51) consisted of patients with increased values of β-ARM (more than 20 standard units). Genetic analysis for the determination of ADRB1 gene polymorphisms (Ser49Gly and Arg389Gly) was carried out by isolating DNA from peripheral blood leukocytes (Wizard Genomic DNA Purification Kit) with PCR amplification and further electrophoretic detection. Statistical processing of the obtained data was carried out using Statistica 10 software and the demo version of IBM SPSS Statistics 20.0.Results: patients with elevated β-APM values were characterized by higher levels of myocardial necrosis markers in the blood (CPK, CPK-MB, and troponin I) in acute myocardial infarction than for patients of the first group (p = 0.009, p = 0.032 and p = 0.001, respectively). In addition, the second group of patients was characterized by a more frequent development of acute left ventricular failure (33.3%, p = 0.026), as well as a history of arterial hypertension before the development of index MI (90.2%, p = 0.044). With regard to the Arg389Gly polymorphism, significant differences were found among patients with normal and increased P-APM values in the acute period of MI. Thus, the second group of patients consisted mainly of carriers of the 1165CC genotype of the ADRB1 gene (n = 29, 56.9%, p = 0.043). The carriage of the 1165G allele was much more often observed among patients of the first group (81.8%; OR = 5.93; CI 1.16-30.25; p = 0.043).Conclusion: an association of the 1165CC genotype of the Arg389Gly polymorphism of the ADRB1 gene with increased β-APM values in acute MI was established. The detected associations may indicate a possible genetic predisposition to SAS hyperactivation, and also indicate the need for further study of polymorphisms and the level of expression of the ADRB1 gene in patients with high individual values of β-APM established in the acute period of MI.

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Association between the osmotic fragility of erythrocytes and the course of acute myocardial infarction

Гарганеева

Александренко

Кужелева

et al. 2021

Kompleks. probl. serdečno-sosud. zabol.

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Aim. To investigate the relationship between the osmotic fragility of erythrocytes and the course of acute myocardial infarction (MI).Methods. An analysis of the osmotic fragility of erythrocytes was conducted using beta-blocker-based osmotic fragility test in sixty-two patients within the first 6 hours after onset of MI symptoms.Results. The results revealed that the patients with increased erythrocyte osmotic fragility experienced more complications after acute MI, such as left ventricular failure and cardiac arrhythmias (ventricular extrasystoles and ventricular tachycardia) (p = 0.026). Moreover, these patients exhibited greater myocardial injury - the concentration of biomarkers of myocardial necrosis, such as creatine phosphokinase, creatine phosphokinase MB and Troponin I was increased - p = 0.009, p = 0.032 and p = 0.001, respectively. In addition to that, the patients with high osmotic fragility had a larger number of hypokinetic and akinetic segments, high impaired myocardial contractility index, and low ejection fraction. The impaired myocardial contractility index was significantly higher in patients with increased erythrocyte osmotic fragility (1.5 (1.22; 1.75) vs 1.12 (1.0; 1.56), U = 157.5, p = 0.032).Conclusion. Increased erythrocyte osmotic fragility in patients was associated with greater myocardial injury, manifesting through the higher concentration of biomarkers of myocardial necrosis in blood, as well as higher number of hypokinetic segments.

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Association of Adrenoreactivity With the Stage of Chronic Heart Failure in Patients With Previous Myocardial Infarction

Cited by 5 publications

References 11 publications

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

Association of beta-adrenergic reactivity index of erythrocyte membranes in myocardial infarction with genetic features of the beta-adrenoreceptor apparatus

Association between the osmotic fragility of erythrocytes and the course of acute myocardial infarction

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