The objective of the study was to assess the impact of DM2 at baseline on long-term mortality after acute myocardial infarction (MI) among different age groups. The data were taken from: “Register of Acute Myocardial Infarction.” A total of 862 patients were followed for five years after acute myocardial infarction. The primary endpoint was death from any cause. The patients were categorized into 2 groups based on their ages: group 1—comprised patients older than working age (n = 358) and group 2—comprised employable patients (n = 504). A total of 208 patients were diagnosed with both cardiovascular disease and DM2. Elderly patients with DM2 had worse prognosis and increased five-year mortality compared with patients of the same age group without DM2. Statistically significant differences in long-term outcomes were found in adult patients (p = 0.004) only in group with longer duration of diabetes, unlike the group with DM2 onset. In conclusion, Type 2 DM increased 5-year mortality rate of elderly patients with myocardial infarction. However, younger patients with both myocardial infarction and DM2 had more complications in the early post-MI period compared with patients of the same age group without DM2 but did not show any statistically significant differences in the long-term outcome.

Aim.To investigate the difference in characteristics of patients admitted to the Tomsk National Research Medical Center with a diagnosis of heart failure (HF) in 2002 and 2016.Methods. Medical charts of all patients hospitalised in a single centre, with a diagnosis of HF, were included. Two three‑month periods were compared from January 2002 (n=210) and January 2016 (n=378).Results.Fewer patients with HF had symptoms or required diuretics in 2016 (63 % vs 98,6 %, p<0.001). During this period the percentage of patients with HFpEF increased from 58.6 % to 74.1 % (p=0.001) whereas those with HFrEF remained similar (19.5 % vs 14.0 %, p=0.1) and those with HFmrEF declined (21.9 % vs 11,9 %, p=0.007). In patients with HFrEF the prescription of ACEi / ARB remained similar (80.4 vs 88 %, p=0.3), beta‑blockers increased from 68 to 85 % (p=0.03) and aldosterone antagonists from 9.7 to 49 % (p<0.001).Conclusion.Prescription rates for prognostic medications in HFrEF improved in 2016. The substantial percentage of patients diagnosed with HFpEF without symptoms or diuretic raises the question of whether a diagnosis of HF was appropriate in some cases.

Aim To study the role of inflammation markers and endothelial dysfunction in predicting the risk of cardiovascular event following a percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) and metabolic syndrome (MS).Materials and methods 80 patients (72 men; median age, 56 (50;63) years) with IHD and PCI were evaluated. Based on the presence of MS according to NCEP-ATP III criteria, patients were divided into two groups, group 1 without MS (n=32) and group 2 with MS (n=48). The control age- and sex-matched group included 15 people without cardiovascular diseases. Serum concentrations of tumor necrosis factor α (TNFα), interleukin 6 (IL-6), IL-10, lipoprotein-associated phospholipase A2 (LP-PLA2), and endothelin 1 were measured by enzyme-linked immunosorbent assay (ELISA). Patients were followed up for 12 months after PCI with evaluation of the incidence of adverse cardiovascular events. Statistical analysis was performed with Statistica 10.0 and Medcalc 19.2.6 software. Differences between variables were considered statistically significant at р<0.05. Potential predictors were determined by the ROC analysis with construction of ROC curves, calculation of AUC (area under the curve), identification of COP (cut-off point by the Youden’s index), and sensitivity (Se) and specificity corresponding to the COP.Results Patients with MS had statistically significantly higher serum levels of inflammatory markers than patients of the control group. Concentration of the intravascular inflammation marker, PL-PLA2, was 2.7 times higher in group 1 and 5.1 times higher in group 2 than in the control group (р<0.001). Concentrations of endothelin 1 were 1.9 times higher in group 1 and 3.7 times higher in the MS group compared to the control. At one year after PCI, the incidence of adverse outcomes in the form of cardiovascular events was higher for patients with MS: 10 (20.8 %) cases of stent restenosis and 13 (27.1 %) episodes of coronary atherosclerosis progression according to results of repeated coronarography vs. 2 (6.3%) restenosis cases (χ2–10.853; р=0.002) and 2 (6.3%) episodes of atherosclerosis progression (χ2–23.651; р=0.001) for patients without MS. The groups did not differ in rates of myocardial infarction and cardiac death. The most significant predictors of unfavorable prognosis were LP-PLA2 concentration >983.83 ng/ml (area under the ROC curve, 0.867; sensitivity, 80 %; specificity, 100%; р<0.001) and endothelin 1 overexpression >0.852 fmol/ml (area under the ROC curve, 0.885; sensitivity, 85.5 %; specificity, 83.6 %; р<0.001).Conclusion Patients with MS were characterized by more pronounced imbalance of pro- and anti-inflammatory factors. Concentrations of LP-PLA2 >983.83 ng/ml and endothelin 1 >0.852 fmol/ml were shown to be predictors of unfavorable prognosis for patients with IHD and MS after PCI with coronary stenting.

Цель. Оценить влияние изменений демографической ситуации на показатели заболеваемости, смертности и летальности населения от острого инфаркта миокарда в Томске за 1984-2010гг. Материал и методы. Исследование проводилось в рамках эпидемиологиче-ской программы ВОЗ "Регистр острого инфаркта миокарда". Эпидемиология инфаркта изучалась среди постоянного населения города в возрасте старше 20 лет. За исследуемый период было зарегистрировано 24850 случаев забо-левания. В остром периоде погибло 9390 больных, в том числе 3314 (36,3%) в стационаре и 6076 (64,7%) -на догоспитальном этапе. Информация о численном и возрастно-половом составе населения города изучалась на основании данных, полученных из областного управления статистики. Результаты. В течение наблюдения демографическая ситуация в городе характеризовалась стойкой тенденцией к постарению населения и увеличе-нию в возрастной структуре больных лиц пожилого и старческого возраста. Этот фактор способствовал росту заболеваемости и смертности населения города от инфаркта миокарда, зарегистрированного в первые годы исследо-вания. Негативно постарение населения сказалось на показателе госпиталь-ной летальности. Преобладание среди больных лиц пожилого и старческого возраста повлекло за собой утяжеление анамнестического фона инфаркта и рост числа случаев атипичного клинического проявления заболевания (аст-матического, абдоминального, коллаптоидного и других вариантов). Это создавало трудности в диагностике заболевания на догоспитальном этапе и способствовало увеличению в структуре госпитализированных больных лиц, получавших лечение в непрофильных стационарах. Высокая летальность в непрофильных лечебных учреждениях и повлекла за собой рост госпиталь-ной летальности в целом по городу. На уровне догоспитальной летальности постарение населения Томска не сказалось. Тем не менее, следует отметить, что в возрастной структуре больных, погибших на догоспитальном этапе, удельный вес лиц пожилого и старческого возраста был практически таким же, как и больных молодых возрастных групп. Заключение. Таким образом, постарение населения способствовало тому, что особенности эпидемиологической ситуации в отношении инфаркта мио-карда в Томске определялись частотой развития данной патологии среди населения старше 60 лет. Сложившаяся ситуация достаточно обоснованно указывает на необходимость изменения стратегии совершенствования сис-темы медицинской помощи больным с острой коронарной патологией в сто-рону акцента последней на контингент старших возрастных групп. Aim. To evaluate the changes in demographic situation influence on morbidity, mortality and lethality from acute myocardial infarction in Tomsk in 1984-2010 y. y. Material and methods. The study was done under the WHO program "Registry of acute myocardial infarction". Epidemiology of infarction was studied among citizens older than 20 y. o. For the period studied there were 24850 cases of the disease registered. In the acute phase 9390 patients died, including 3314 (36,4%) inpatients and 6076 (64,7%) -prehospital patients. Information on...