Association of aging-related obesity and metabolic syndrome in men

Пинхасов, Б. Б.; Selyatitskaya, V. G.; Karapetyan, A. R.; Lutov, Yu. V.

doi:10.1134/s2079057016030085

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Анализ возрастной и антропометрических характеристик мужчин в выделенных группах представлен в таблице 1. Динамика увеличения возраста мужчин от группы 2 к группе 3 и далее к группе 4 согласуется с ранее полученными результатами [20], указывающими, что в ходе онтогенеза частота ПТРЖ снижается и в старших возрастных группах доминирует АТРЖ. Мужчины группы 2 с ПТРЖ по всем антропометрическим характеристикам, кроме величины ОТ/ОБ, отличались в большую сторону от мужчин группы 1 с нормальной массой тела.…”

Section: результаты объекты (участники) исследованияunclassified

“…Тип распределения жировой ткани в организме определяется конституцией человека, возрастом и другими факторами [20]. Обсуждается гипотеза, что за общую эпидемию ожирения в мире отвечают условия окружающей среды, в то время как тип распределения жира в организме определяют генетические факторы [25].…”

Section: обсуждение основного результата исследованияunclassified

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The features of psychological state, eating behavior, hormonal and adipokine regulation of metabolism in men with subcutaneous and abdominal fat distribution

Mokhova¹,

Пинхасов²,

Shilina³

et al. 2020

Obes. metabol.

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BACKGROUND: development of obesity and obesity related conditions are directly associated with eating disorders and psychological state. There is increasing focus on the assessment the characteristics of these indicators in men with subcutaneous and central fat distribution, which are associated with various hormonal and adipokine mechanisms that effect on parameters of metabolism and eating behavior. AIMS: to study the characteristics of the psychologycal state, eating behavior and their relationship with hormonal and adipokine status in men with different fat distribution. MATERIALS AND METHODS: a single-center, cross-sectional study of 99 men aged 27 to 68 years was performed. 4 groups of men were formed after anthropometric examination. Group 1 (comparison) consisted of men with normal body weight. Group 2 consisted of overweight men, class I obesity and lower subcutaneous fat distribution (SFD). Group 3 consisted of overweight men, men with class I obesity and abdominal fat distribution (AFD); group 4 - men with class II obesity and class III obesity AFD. Eating behavior were determined with DEBQ questionnaire, severity of anxiety-depressive disorders were investigated with the Hospital Anxiety and Depression Scale; body image satisfaction was assessed with body image questionnaire. Serum glucose, triglycerides, insulin, leptin and adiponectin were estimated. RESULTS: it was shown, that men with AFD had severe metabolic disorders: hyperglycemia, hypertriglyceridemia, hyperinsulinemia and insulin resistance, hyperleptinemia and hypoadiponectinemia, than men with SFD. Men with AFD had an external type of eating behavior, with sever expressed depressive disorders and body image dissatisfaction. Men with SFD had an emotional type of eating behavior and higher body image satisfaction. A comparative analysis between men from 3 and 4 groups with AFD showed that in group 4 in men had higher hyperleptinemia and insulin resistance and there are no differences in severity of eating disorders, anxiety and depression between the groups. CONCLUSIONS: adipose tissue topography is associated with the psychophysiological, metabolic, hormonal and adipokine characteristics that underlie the development of primary obesity in men.

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Section: результаты объекты (участники) исследованияunclassified

Section: обсуждение основного результата исследованияunclassified

The features of psychological state, eating behavior, hormonal and adipokine regulation of metabolism in men with subcutaneous and abdominal fat distribution

Mokhova¹,

Пинхасов²,

Shilina³

et al. 2020

Obes. metabol.

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“…MS is often associated with depression of pulmonary function and reduction of forced expiratory volume in one second (FEV 1 ) rather than only with abdominal obesity, arterial hypertension and different cardiovascular diseases [12,13]. MS, bronchial obstruction and deterioration of pulmonary function can mutually potentiate one another [14,15].…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of Metabolic Changes in Asthma

et al. 2020

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The aim: Revealing of clinical-pathogenetic peculiarities in manifestations of uncontrolled As+MS. Materials and methods: Sixty-five cases, divided into 2 groups: Group I – severe As (n=20), Group 2 – severe As+MS (n=45). The general clinical examination included fasting blood glucose, insulin level, HOMA-IR index, body mass index (BMI), spirometry, levels of ММР-9, МСР-1, IL-8 and IL-12. Results: In Group I, 20 patients (100%) had obstructive respiratory dysfunction. Group II had 13 cases (28.88%) with the restrictive, 15 (33.33%) with the obstructive and 17 (37.77%) with the mixed types. BMI revealed: Group I had the normal mass (BMI averaged 24.62 [22.76; 25.71]; Group II had 21 overweighed cases (46.66%) and 24 (53.33%) with grade 1 obesity, averaging 29.70 [28.35; 31.23]. Correlation analysis in Group II showed significant correlations between: age and WHR (r=0.52, p<0.001) (increase of abdominal fat depots during life), FEV1 and BMI (r=-0.63, р<0.001) (obesity affects pulmonary function). IL-8 and IL-12 levels in Group II were increased, respectively, by 27.86 and 13.18 times versus Group I. A relationship was found between MCP-1 and MMP-9 (r=0.77, р<0.05), Group II revealed direct correlation between MCP-1 and total FEV1 (r=0.53, р<0.05). Conclusions: Overweight and obesity in As+MS deteriorate respiratory function versus the same indices in isolated As. Relationships between proinflammatory cytokines and MMP-9 and MCP-1 prove pathogenetic peculiarities of systemic inflammation and metabolic homeostasis. As and MS can cause their coexistence, facilitating development of mutual aggravation.

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“…We have previously shown that men and women with android and gynoid obesity have different frequencies of metabolic syndrome (MS) and its components with significantly higher frequency for android obesity (5,6,7). Men and women with gynoid obesity had no hyperglycemia (MS component), and the risk of insulin resistance, and T2DM was therefore minimal (5).…”

Section: Introductionmentioning

confidence: 99%

Hormonal Regulation of Carbohydrate and Fat Metabolism in Women with Different Obesity Types in the Food Deprivation Test

et al. 2019

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Context. The dominant type of adipose tissue accumulation in the body is associated with the peculiarities of using key substrates in energy metabolism and their hormonal regulation. Hormonal and metabolic parameters were investigated in women with android and gynoid obesity before and after the short-term food deprivation test.Results. At baseline, at gynoid obesity as compared to android obesity, the women's blood contained lower glucose and insulin levels and higher FFA levels. The reaction to food deprivation manifested by a decrease in glucose level and an increase in FFA level in the blood is less pronounced in women with gynoid obesity than in those with android obesity. At the same time, a similar (though varying in expression) decrease in insulin level and elevated levels of glucagon, growth hormone and thyroxine were revealed in women's blood in both groups. Blood cortisol level increased in women with gynoid obesity and remained unchanged in those with android obesity.Conclusions. More pronounced activation of hormonal mechanisms for maintaining blood glucose levels at gynoid obesity as compared to android one suggests that glucose is the preferable substrate for energy metabolism at gynoid obesity in women.

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Association of aging-related obesity and metabolic syndrome in men

Cited by 5 publications

References 11 publications

The features of psychological state, eating behavior, hormonal and adipokine regulation of metabolism in men with subcutaneous and abdominal fat distribution

The features of psychological state, eating behavior, hormonal and adipokine regulation of metabolism in men with subcutaneous and abdominal fat distribution

Peculiarities of Metabolic Changes in Asthma

Hormonal Regulation of Carbohydrate and Fat Metabolism in Women with Different Obesity Types in the Food Deprivation Test

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