Association of alcohol withdrawal severity with MTNR1A (rs34532313) and MTNR1B (rs10830963) genes polymorphisms

Efremov, I. S.; Tukhvatullina, Dina; Efremova, U. S.; Gashkarimov, V. R.; Tulbaeva, N. R.; Akhmetova, E. A.; Гизатуллин, Т. Р.

doi:10.52667/2712-9179-2021-1-2-111-116

Cited by 2 publications

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“…The relationships found correlate with previously discovered clinical results [18]. Despite the description in literature of some genetic associations of melatonin receptor genes [19,20,21,22], the connections found by us are described for the first time. The results obtained indirectly confirm our hypothesis about the connection between suicidal behavior and insomnia disorders through genetic variants of melatonin receptor genes.…”

Section: Discussionsupporting

confidence: 83%

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Association of single nucleotide variants rs34532313 of the MTNR1A gene and rs10830963 of the MTNR1B gene with suicidal risk in alcohol dependence syndrome and insomnia

Efremov

Asadullin

Akhmetova

et al. 2022

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Background: Suicidal behaviour is the leading cause of mortality from external causes at all ages worldwide. More than a million people commit completed suicide each year. According to the World Health Organisation, 25-50% of suicide victims suffered from alcohol and other substance use disorders, 22% of all suicide deaths were attributable to alcohol use (WHO, 2014). Several papers have suggested potential associations of insomnia and increased suicide risk in patients with alcoholism. We hypothesise that mutations in melatonin receptor genes may be associated with suicide risk in patients with alcoholism.Methods. The Insomnia Severity Index (ISI) was used as a tool to assess the presence and severity of insomnia. The Columbia Suicide Severity Rating Scale (C-SSRS) was used as a method to examine suicidal behavior. Genotyping of MTNR1A (rs34532313), MTNR1B (rs10830963) genes was performed using real-time polymerase chain reaction (RT-PCR). A comparative genetic study of two groups of patients was carried out: the first group, patients with alcohol dependence syndrome (F10.2); the second group, patients with alcohol dependence syndrome (F10.2) and insomnia, which persisted 7-14 days after starting alcohol withdrawal therapy.Results. Suicidal thoughts and a history of auto-aggressive behaviour were more common in subjects with insomnia in the post-withdrawal period. Carriers of the TT genotype of the MTNR1A gene (rs34532313) were more likely to have suicidal thoughts and a history of suicide attempts in a genetic study of patients with insomnia.Conclusions. Our study found that the TT genotype of the MTNR1A gene (rs34532313) is a genetic marker of suicidal behaviour risk in patients with insomnia in the post-withdrawal period. However, the same pattern was not observed in patients without insomnia.

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Section: Discussionsupporting

confidence: 83%

“…All patients underwent a neurological examination; no severe neurological pathology was revealed. 325 patients were screened, 19 were not included in the study in accordance with the exclusion criteria. The final sample included 306 patients.…”

Section: Methodsmentioning

confidence: 99%