Association of ALOX5AP with ischemic stroke in eastern Chinese

Abstract

BACKGROUND: 5-lipoxygenase protein (ALOX5AP) has been recognized as a susceptibility gene for stroke and coronary artery diseases. The present study was to explore the role of this gene in the eastern Chinese patients with ischemic stroke. METHODS: Using a case-control design, we studied 658 patients with ischemic stroke and 704 unrelated population-based controls who were age-and sex-matched. The 658 patients were classified by the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Two single-nucleotide polymorphisms (SNPs) covering ALOX5AP were genotyped. RESULTS: The genotype frequencies of TG of the SNPs rs17222919 located in the promoter of the ALOX5AP gene were significantly higher in patients with ischemic stroke than in controls (OR * =1.34, 95%CI * =1.02-1.75), especially in patients with ischemic stroke caused by small-artery occlusion (SAO) (OR * =1.40, 95%CI * =1.02-1.93). Meanwhile, the genotype frequencies of TG and TG/ GG were higher in female patients than in the controls. After specifi cation, the genotype frequencies of TG and TG/GG were higher in the patients than in controls with hypertension. The genotype frequencies of AG and AG/GG of the SNPs rs9579646 located in the intron of the ALOX5AP gene were higher in the controls than in the patients. After specification, the genotype frequencies of TG were higher in the controls than patients without hypertension. CONCLUSION: The present study suggests that sequence variants in the ALOX5AP gene are signifi cantly associated with ischemic stroke.

Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance

“…T allele carriers were found to possess lower expression of ALOX5AP1 gene. It has been shown that there is an increased production of LTB4 in neutrophils from patients with a history of myocardial infarction compared to controls without history of myocardial infarction [17]. Expression studies have supported this where an increased expression of members of 5 lipoxygenase pathway including 5 lipoxygenase and ALOX5AP in atherosclerotic lesion at various stages of their development has been shown [28].…”

“…Expression studies have supported this where an increased expression of members of 5 lipoxygenase pathway including 5 lipoxygenase and ALOX5AP in atherosclerotic lesion at various stages of their development has been shown [28]. These studies suggest that chronic upregulation of leukotriene pathway may be harmful to the vasculature, in terms of atherosclerotic progression and plaque stability [17].…”

“…Leukotriene-based inflammation has been known to play a crucial role in atherosclerosis [2]. Many studies have shown the association of variants in leukotriene pathway genes with the risk of atherosclerotic disease including stroke [14][15][16][17]. Therefore, the present study was carried out with an aim to investigate the association of SG13S113 T/A polymorphism of ALOX5AP1 gene with stroke and stroke subtypes in a South Indian population from Andhra Pradesh.…”

Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times

“…The death rate in the two groups was approximately 6.7%, which was lower than the results of the NINDS test (17%) and ECASS test (22.4%). [ 6 , 11 ] Therefore, we consider that it is safe to perform rt-PA thrombolysis within 4.5–6 hours after the onset of ACI. García-Bermejo et al[ 19 ] has the same result.…”

“…The sooner the treatment begins, the better the efficacy would be. [ 6 , 7 ] Our department has a multidisciplinary team in collaboration with the departments of neurology, neurosurgery, radiology, and clinical laboratory in the second half of year 2008. In this study, cerebral stroke patients were primarily selected from the department of emergency medicine to enter the green channel.…”