Association of alterations in energy metabolism with lead-induced delays in rat cerebral cortical development

McCauley, P T; Bull, Richard J.; Lutkenhoff, S.D.

doi:10.1016/0028-3908(79)90014-5

Cited by 34 publications

(4 citation statements)

References 30 publications

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“…Investigation to a study reported that high Pb exposure in nursing rat pups causes an increase in ADP-independent respiration in brain, mitochondria and delayed development of brain dicarboxylic amino acid metabolism. Epidemiological studies have also found correlative evidence of modestly increased exposure to Pb with mental retardation [63].…”

Section: Alpha Thalassemiamental Retardationmentioning

confidence: 99%

Toxicology of Heavy Metals Used in Cosmetics

Raza-Naqvi

Idrees

Sherazi

et al. 2022

J. Chil. Chem. Soc.

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Cosmetics have been used by humans since the start of human civilization. Initially, it was typically consisting of natural products but to get prompt results, heavy metals were frequently added to cosmetics to accelerate the affects. Heavy metals such as mercury (Hg), lead (Pb), cadmium (Cd) and chromium (Cr) are detected in various cosmetic products; most frequently in color cosmetics, hair cosmetics, face-body care products and beauty cosmetic products. These metals are included in toxic metals. The application of cosmetics to different body parts leads to the absorption of metals through the stratum corneum into the blood, accumulate or replace essential elements of different biomolecules which triggers the unfavorable mechanism. Reported data shows that in some common cosmetic products toxic metals are being used greater than permissible limit. The United States Food and Drug Administration (FDA) and World Health Organization (WHO) have established the highest permissible limit of exposure for heavy metals in different cosmetic products. However, commonly in developing world no care is taken for permissible limit set by FDA and WHO and to obey cosmetic production legislations which resulted in fatal health consequences. Thus, in this review article we are focusing on the permissible limits, hazardous effects of the toxic metals and mechanisms associated with the hazardous effects related to heavy metals found in cosmetics. Owing to the growing usage of cosmetics it is necessary to explore the possible sources and routs of metals toxicity to fix the hazardous effects related to heavy metals found in cosmetics.

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Section: Alpha Thalassemiamental Retardationmentioning

confidence: 99%

Toxicology of Heavy Metals Used in Cosmetics

Raza-Naqvi

Idrees

Sherazi

et al. 2022

J. Chil. Chem. Soc.

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“…11 " 16 Smith, et al 17 and Winneke, et al 18 report an inverse but less significant association between body lead burdens and childrens' intellectual performance. This general consistency in findings is probably due to the neurotoxic potency of lead, a property that has been demonstrated in rodents, 19 and primates, 20 and has been suggested by studies of the effect of lead in brain homogenates. 21 Recently, a spate of papers has conjectured that the reports of Needleman et al* and others could be spurious because of measurement error and omitted variable bias.…”

Section: Discussionmentioning

confidence: 61%

The importance of specification uncertainty and intolerance to measurement error in a study of the impact of dentine lead on childrens’ IQs

Atkinson

Crocker

Needleman

1987

International Journal of Environmental Studies

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Needleman et al. concluded that, on average, an increase in the dentine lead of children from <6 ppm to >24 ppm was associated with a 4-point IQ decrement. Recently, a spate of papers has conjectured that the reports of Needleman et al. and others could be spurious because of measurement error and omitted variable bias. In this Bayesian analysis of the reconstituted Needleman et al. data set, we replace such conjectures by empirical tests. Even though we structure the tests to provide very favourable opportunities for the conjectures to acquire support, the possibility is seen to be remote that omitted variable bias significantly alters the estimated influence of lead exposures upon childrens' psychometric intelligence. Similarly, the Bayesian analysis demonstrates that other included covariates are likely to affect the estimated influence of lead exposures only if they are quite poorly measured.

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“…Wrist drop is an obvious sign of of cytochrome metabolism has also been found (294)(295)(296). Wrist drop is an obvious sign of of cytochrome metabolism has also been found (294)(295)(296).…”

Section: Peripheral Nervous Systemmentioning

confidence: 83%

Metabolism and Toxicology of Lead

Taylor

1986

Reviews on Environmental Health

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Metabolism and toxicology of leadAmong the metals which are described as biological trace elements, lead has attracted the greatest interest.In part, this is a reflection of the extensive use of the metal for industrial and related purposes over several thousands of years (1-3) and the well recognised symptoms of toxicity (4).In addition, concern has been increasing at the amount of "environmental lead" to which the population may be exposed.Environmental sources of lead include foods, paint pigments and lead in petrol and are discussed in greater detail below.Lead has not been demonstrated to be an essential trace element with symptoms of deficiency developing if inadequately supplied. Nevertheless, nutritional aspects of the metal have been recently studied following recognition that interactions with other dietary constituents can influence toxicity.With very few exceptions exposure is to metallic lead e.g. as the vapour or to inorganic lead salts. Tetra-ethyl and other organo lead compounds are exceedingly toxic, but it is unusual for persons not associated with their manufacture or their use in the petroleum industry to receive significant exposure.This review, therefore, will not include details of organolead toxicity.

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Association of alterations in energy metabolism with lead-induced delays in rat cerebral cortical development

Cited by 34 publications

References 30 publications

Toxicology of Heavy Metals Used in Cosmetics

Toxicology of Heavy Metals Used in Cosmetics

The importance of specification uncertainty and intolerance to measurement error in a study of the impact of dentine lead on childrens’ IQs

Metabolism and Toxicology of Lead

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