Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome

Zhang, Bingjie; Wang, Jing; Shen, Shanmei; Liu, Jiayi; Sun, Jie; Gu, Tianwei; Xiao, Ye; Zhu, Dalong; Bi, Yan

doi:10.1155/2018/6869705

Cited by 38 publications

(32 citation statements)

References 37 publications

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“…Furthermore, insulin directly stimulates androgen synthesis by the theca cell. Therefore, the improvement of insulin sensitivity and the resultant decrease in circulating insulin could decrease testosterone levels, as previously reported, that improvement in insulin resistance through weight loss or the use of insulin-sensitizing drugs leads to a decrease in hyperandrogenemia [43,44]. For the rst time, we observed that thylakoid-rich spinach extract with a hypocaloric diet decreased DBP and serum levels of hs-CRP, without effect on the SBP in obese women with PCOS after 12 weeks.…”

Section: Discussionsupporting

confidence: 71%

The Effects of Thylakoid-Rich Spinach Extract Combined with the Calorie-Restricted Diet on Cardiometabolic Risk Factors in Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial

Tabrizi

Farhangi

Vaezi

et al. 2020

Preprint

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Background: The polycystic ovary syndrome (PCOS) was associated with a higher risk of cardiovascular diseases, related to metabolic dysfunction, due to its peculiar hormonal pattern, dyslipidemia, and inflammatory state. This study was aimed to investigate the effects of thylakoid-rich spinach extract supplementation combined with a hypocaloric diet on cardiometabolic risk factors in obese women with PCOS. Methods: In a double-blind, placebo-controlled design, forty-eight participants (age 20–45 years) consumed in random order either a thylakoid-rich spinach extract powder (5g) or a matched placebo (5g starch), given daily combined with the hypocaloric diet for 12 weeks. The samples were collected at baseline and after the end of the supplementation. The primary outcome was the measure of anthropometric changes, glycemic indices, and lipid profile. The secondary outcomes included inflammatory status and blood pressure. Results: Thylakoid-rich spinach extract supplementation combined with the restricted-calorie diet was associated with significant reductions in abdominal obesity indicators, insulin resistance, lipid accumulation product (LAP), and diastolic blood pressure (DBP) (P< 0.05). Significant decreases were also seen in serum triglycerides (TG), insulin, high-sensitivity C-reactive protein (hs-CRP), and total testosterone compared with the placebo group (P< 0.05). However, no significant differences in systolic blood pressure (SBP) and in serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and fasting blood glucose were evident between groups at the end of study ( P>0.05). Conclusions: Thylakoid-rich spinach extract supplementation combined with the calorie restriction for 12 weeks may improve the cardiometabolic risk factors in obese women with PCOS.Trial registration: The study was approved by the Ethics Committee of Research Vice-chancellor of Tabriz University of Medical Sciences, Tabriz, Iran, and was registered in the Iranian Registry of Clinical Trials (IRCT20140907019082N9).

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Section: Discussionsupporting

confidence: 71%

The Effects of Thylakoid-Rich Spinach Extract Combined with the Calorie-Restricted Diet on Cardiometabolic Risk Factors in Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial

Tabrizi

Farhangi

Vaezi

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Rather, they are closely associated with testosterone levels (Holte et al 1994). Finally, there is a robust relationship between β cell dysfunction and testosterone concentrations in these women (Goodarzi et al 2005, Zhang et al 2018. Since the AR is expressed in β cells in females, this raises the possibility that excess testosterone produces insulin hypersecretion and β cell dysfunction.…”

Section: Testosterone Action In β Cells In Womenmentioning

confidence: 99%

Emerging role of testosterone in pancreatic β cell function and insulin secretion

Morford

Mauvais-Jarvis

2019

Journal of Endocrinology

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One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose homeostasis by testosterone in male and females. Severe testosterone deficiency predisposes men to type 2 diabetes (T2D), while in contrast, androgen excess predisposes women to hyperglycemia. The role of androgen deficiency and excess in promoting visceral obesity and insulin resistance in men and women respectively is well established. However, although it is established that hyperglycemia requires β cell dysfunction to develop, the role of testosterone in β cell function is less understood. This review discusses recent evidence that the androgen receptor (AR) is present in male and female β cells. In males, testosterone action on AR in β cells enhances glucose-stimulated insulin secretion by potentiating the insulinotropic action of glucagon-like peptide-1. In females, excess testosterone action via AR in β cells promotes insulin hypersecretion leading to oxidative injury, which in turn predisposes to T2D.

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“…Several factors support the fact that hyperandrogenism can determine the characteristic phenotype PCOS, including, abnormalities of the menstrual cycle, hirsutism and polycystic ovaries [35][36][37]. Excessive levels of androgens may also promote insulin resistance and the dysfunction of β-cells in PCOS patients [38]. One previous study showed implicated lncRNA H19 in the development of neuroendocrine prostate cancer (NEPC), an androgen-related disease; this was suggestive of a potential regulatory role for lncRNA H19 expression with androgen levels [28].…”

Section: Discussionmentioning

confidence: 98%

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study

et al. 2019

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Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. In the current study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to determine lncRNA H19 expression levels in peripheral blood leukocytes from patients with PCOS and compared this data with that derived from normal controls. We also screened data for potential relationships between lncRNA H19 and a range of endocrine variables in PCOS. The expression of lncRNA H19 was significantly higher in cases of PCOS than in controls. Individuals exhibiting higher expression levels of lncRNA H19 were associated with a significantly higher risk of PCOS than those with lower expression levels. Moreover, lncRNA H19 expression was positively correlated with fasting plasma glucose levels; this was the case with both raw data, and after adjustment for age and BMI in the PCOS group. However, lncRNA H19 expression showed no significant correlation with total testosterone or insulin resistance in either PCOS cases or the controls. In conclusion, we demonstrate the first evidence to indicate that lncRNA H19 is associated with PCOS, suggesting that elevated lncRNA H19 levels are a risk factor for PCOS. For susceptible individuals, lncRNA H19 may represent a useful biomarker of the early stages of endocrine and metabolic disorders in PCOS.

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Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome

Cited by 38 publications

References 37 publications

The Effects of Thylakoid-Rich Spinach Extract Combined with the Calorie-Restricted Diet on Cardiometabolic Risk Factors in Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial

The Effects of Thylakoid-Rich Spinach Extract Combined with the Calorie-Restricted Diet on Cardiometabolic Risk Factors in Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial

Emerging role of testosterone in pancreatic β cell function and insulin secretion

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study

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