Association of angiotensin converting enzyme (ACE) gene I/D polymorphism and polycystic ovary syndrome (PCOS)

Bayram, Banu; Kilicci, Cetin; Önlü, Harun; Özkurt, Mete; Erkasap, Nilüfer; Yıldırım, Engin; Şahin, Fezan

doi:10.1016/j.gene.2011.08.012

Cited by 17 publications

(16 citation statements)

References 20 publications

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“…In addition, BMI and W/H ratio were also higher in the patient group than controls. Our study results correspond to the findings by Karabulut et al and Bayram et al [18,20].…”

Section: Discussionsupporting

confidence: 94%

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Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Deepika

Reddy

Rani³

et al. 2012

J Assist Reprod Genet

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Background Polycystic ovary syndrome (PCOS) is an endocrine disorder exhibiting variable age at onset of clinical features allied with complex diseases in the later life. ACE is a pleiotropic molecule associated with various pathophysiological functions. The present study was aimed to establish the frequency of ACE I/D gene polymorphism in patients and controls and to assess the influence of this polymorphism on anthropometric and various clinical features of the condition. Methods ACE I/D genotyping was carried out in 259 PCOS patients and 315 healthy ultrasound scanned women of South Indian origin.Results The distribution of DD, ID and II genotypes in patients was 39, 37 and 24 %, whereas in the controls it was 31, 51 and 18 % respectively. Significant difference was observed in the genotypic frequency distributions between the patients and controls, however the allelic frequencies did not vary between the groups (p>0.05). Quartile analysis revealed preponderance of DD genotype in the first two quartiles and a linear increase of II genotype from first to the last quartiles. Further, Multiple Logistic regression analysis revealed significant association of ACE I/D gene polymorphism with acanthosis and age at onset (AAO) of the syndrome (p<0.05). Conclusion The present study is the first report to highlight the predisposing role of DD and protective role of ID genotype towards PCOS. Patients with single or double dose of D allele may develop PCOS symptoms at an early age and also significantly associated with acanthosis, a marker of insulin resistance.

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“…In addition, BMI and W/H ratio were also higher in the patient group than controls. Our study results correspond to the findings by Karabulut et al and Bayram et al [18,20].…”

Section: Discussionsupporting

confidence: 94%

“…The production angiotensin II of the RAS can make follicle atresia in every period of the follicle development and promote the formation of polycystic ovary and hyperandrogenism [20]. ACE is expressed in multiple tissues including ovaries and also implicated in various diseases [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Deepika

Reddy

Rani³

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

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“…However, a study in the Turkish population that analysed 100 patients with PCOS and 100 controls, and a Polish study with 138 patients and 110 controls showed differences between the groups using the same analysis, indicating that the deletion may be a risk factor for PCOS. 17,18 Our results are according to a study in South India with 582 women of reproductive age (346 with PCOS and 236 controls) who found no association between the I/D polymorphism in the ACE and PCOS, but the multiple logistic regression analysis found an association of the deletion polymorphism with age of onset of disease and acanthosis. 19 In our study multiple logistic regression analysis was performed and no differences were detected between the clinical consequences of PCOS analysed (clinical hyperandrogenism, pregnancy-related problems), and presence of the polymorphism.…”

Section: Discussionmentioning

confidence: 51%

Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene

Cintra

Balarin

Tanaka

et al. 2018

Rev. Assoc. Med. Bras.

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SUMMARY PURPOSE: To investigate the contribution of the deletion polymorphism and insertion (rs1799752) of the angiotensin converting enzyme (ACE) gene in the aetiology of Polycystic Ovarian Syndrome (PCOS). METHODOLOGY: 97 women diagnosed with PCOS who received care at the Gynaecology and Obstetrics clinic of the Hospital das Clínicas of UFTM, participated in this study. The control group consisted of 94 women. All participants were submitted to the collection of 10 mL of whole blood and the genomic DNA was obtained by the saline extraction method. The genotyping of the samples was performed by means of the Polymerase Chain Reaction (PCR). The statistics analyses were performed by descriptive analysis, univariate analysis and logistic regression model. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p≤0.05). RESULTS: There were no statistical differences between patients and controls for the genotypic (χ2 = 1.52, p = 0.47) and allelic frequencies (χ2 = 0.21, p = 0.76). The distribution of the genotypic frequency is not in HWE for patients (χ2 = 18.80, p <0.05) and for controls (χ2 = 6.85, p <0.05). In relation to the risk factors for the syndrome, the history of familial PCOS is more frequent between women with the syndrome. CONCLUSION: In the study population, there was no association between I/D polymorphism of the ACE gene and PCOS.

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“…Among the 8 studies imported in the meta-analysis, 6 of them had been covered by Jia et al meta-analysis (13)(14)(15)(16)(17)(18). Analyses were performed in 5 different groups of alleles and genotypes including D vs I (Figures 2, 3), DD vs II (Figures 4, 5), DD+DI vs II (Figures 6, 7), DD vs DI+II (Figures 8, 9), and DI vs DD+II (Figures 10, 11).…”

Section: Resultsmentioning

confidence: 99%

Polycystic Ovary Syndrome is Affected and Protected by DD and DI Genotypes of Angiotensin Converting Enzyme, Respectively: An Update of a Meta-Analysis

Yari¹,

Ali²,

Abbaszadeh³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

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IntroductionAngiotensin converting enzyme (ACE) is a renal enzyme catalyzing the conversion of angiotensin 1 to angiotensin 2. This, results in production of the aldosterone resulting in natrium retention and potassium excretion. ACE gene has 3 polymorphic genotypes of II, DI and DD. It has been observed in several studies and meta-analyses that patients with DD genotype are more at risk of renal and cardiovascular diseases. It seems that these effects could be due to hyperactivity of ACE gene in such patients (1,2). In addition to kidneys, ovaries have renin angiotensin system (RAS). The role of this system in ovulation and reproduction is not completely understood (3).Different histopathologic and angiogenic abnormal conditions result in pregnancy complications (4). Polycystic ovary syndrome (PCOS) is one of such conditions resulting in infertility and other complications of women's reproductive system (5). Based on a metaanalysis conducted by Jalilian et al, prevalence of PCOS in Iran was 6.8%, 4.41% and 19.5% based on NIH, ultrasound and Rotterdam criteria, respectively (6). Type 2 diabetes, obesity, metabolic syndrome, hypertension and so on are considered as risk factors of PCOS (7-9). Also metformin is used for the treatment, because of insulin resistance in such patients (10). All of these evidences give us clues that hypertension related genes like ACE my play roles in pathogenesis of PCOS. Of course it is not clear whether this role is associated with renal RAS, ovarian RAS or both.On the occasion of the clues and findings above, we intend to update the only meta-analysis conducted by Jia et al in 2013 on the association of ACE gene polymorphism and risk of PCOS (11). The reason of our attempt to update this meta-analysis was that Jia et al did not find any significant relation in their random-effect model meta-analysis. Materials and MethodsWe searched in databases for relevant keywords in the titles of the articles (Figure 1). Finally we found 8 relevant papers based on our inclusion criteria (similar protocols including similar criteria for their PCOS and control groups). In order to perform this meta-analysis, we used comprehensive meta-analysis version 2 software (Biostat, US). The analysis was done through the P value and sample size of each study using fixed-effect model. Analyses were performed in 5 different groups of allele and genotype comparisons (Table 1). This meta-analysis Abstract Objectives: Angiotensin converting enzyme (ACE) is an important enzyme involved in the physiopathology of renal, cardiovascular and ovarian systems. One of these ACE related diseases is polycystic ovary syndrome (PCOS). Materials and Methods:We intend to update the only meta-analysis written by Jia et al in 2013 on the association of ACE gene polymorphism and risk of PCOS. The reason of our attempt to update this meta-analysis was that they found no significant relation in their meta-analysis. For this aim, we searched in databases for relevant documents. Results: We found 8 relevant papers, 6 of which had bee...

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Association of angiotensin converting enzyme (ACE) gene I/D polymorphism and polycystic ovary syndrome (PCOS)

Cited by 17 publications

References 20 publications

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene

Polycystic Ovary Syndrome is Affected and Protected by DD and DI Genotypes of Angiotensin Converting Enzyme, Respectively: An Update of a Meta-Analysis

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