Association of angiotensin-converting enzyme G2350A gene polymorphisms with hypertension among patients with intracerebral haemorrhage

Abstract

Objectives To evaluate the correlation of angiotensin-converting enzyme (ACE) G2350A gene polymorphisms with hypertension, brain hematoma volume (BHV), level of consciousness, and disease outcome among intracerebral haemorrhage (ICH) patients. Methods A cross-sectional study was conducted in Zainoel Abidin General Hospital from May 2016 to June 2017. Polymerase chain reaction was used to genotype ACE G2350A gene polymorphisms. BHV was assessed using the ABC/2 volume estimation formula. Level of consciousness was assessed by Glasgow coma scale (GCS). Disease outcome was assessed using Glasgow outcome scale (GOS). Association tests for ACE G2350A genotype in the context of hypertension status, BHV, GCS score, and GOS score in subjects with ICH was analysed by multiple logistic regression. Results A total of 75 ICH patients were included in the study. Of those, 59 patients exhibited hypertension, 24 patients had BHV ≥60 cm 3 , 16 patients possessed GCS scores ≤8, and 72 patients had GOS scores of 1–3. Our analysis determined that the A allele of the ACE G2350A gene polymorphism was significantly associated with a 3.6-fold increase in hypertension; however, this polymorphism was not associated with BHV, level of consciousness, and disease outcome among ICH patients. Conclusion The A allele of the ACE G2350A gene polymorphisms is associated with hypertension among ICH patients.

Polymorphism Patterns and Socioeconomic Characteristics and Their Influence on the Risk of Preeclampsia

“…Research suggests that genetic variations within RAS genes, such as angiotensin-converting enzyme (ACE), may influence the balance of vasoactive substances, leading to characteristic aberrant vascular responses in PE [ 15 ]. Specifically, the ACE G2350A polymorphism, through its impact on ACE enzyme activity, has been linked to altered levels of angiotensin II and bradykinin, key mediators of vascular tone and endothelial function [ 16 ]. Additionally, emerging evidence suggests a link between immune dysfunction and the pathogenesis of PE [ 17 ].…”

Angiotensin-converting enzyme G2350A gene polymorphisms and hypertension among patients with intracerebral hemorrhage

“…” We would like to share ideas on the present report. In this article, the G to A variant was found for relationship with increased risk of HT 1 . In fact, the important change due to ACE G2350A gene polymorphism is the molecular structure change.…”

“…Dear Editor, we read the publication on “Association of angiotensin-converting enzyme (AVE) G2350A gene polymorphisms with hypertension (HT) among patients with intracerebral haemorrhage”” with a great interest 1 . Imran et al.…”

“…Imran et al. concluded that “ The A allele of the ACE gene polymorphisms is associated with hypertension among ICH patients 1 …”