Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis

Xu, Guodong; Fan, Guohui; Sun, Yingtong; Yu, Lili; Wu, Sinan; Niu, Wenquan

doi:10.1177/1470320318770546

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…Twelve articles were in English, 7 , 10 , 11 , 13 , 15 – 20 , 23 , 25 and three were in Chinese. 21 , 22 , 24 Among these studies, five were conducted in Asians and ten in Caucasians. Additionally, according to the quality-score evaluation, six articles were of moderate quality, and the others were of high quality.…”

Section: Resultsmentioning

confidence: 99%

<em>ACE</em> gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

Ma¹,

Xiang²,

Liu³

et al. 2018

COPD

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PurposeAngiotensin-converting enzyme (ACE) gene I/D polymorphism has been studied in relation to the susceptibility to COPD and COPD with pulmonary hypertension (PH) with inconclusive results. We performed the first comprehensive meta-analysis to evaluate accurately the association between the ACE gene polymorphism and the risk of COPD.MethodsData were analyzed using odds ratios (ORs) and the corresponding 95% CIs to measure the strength of the models. Subgroup analyses were conducted by ethnicity and complication which referred to PH.ResultsIn total, 15 studies (2,635 participants) were included in our study, of which four studies (288 participants) were for PH subgroup. The overall analysis results indicated that the ACE gene polymorphism was not associated with COPD susceptibility in all gene models. However, the ethnic subgroup analysis results indicated that ACE gene polymorphism was associated with Asians’ susceptibility to COPD (DD+DI vs II, OR=1.47, P=0.019, 95% CI: 1.07–2.02). Further, the overall results of the present study detected no statistical significance between ACE gene polymorphism and the risk of COPD with PH, but the homozygote variant (DD) increased the risk of PH in Asian COPD patients (DD vs ID+II, OR=2.05, P=0.05, 95% CI: 1.00–4.19).ConclusionThe current study suggests that ACE polymorphism, particularly the homozygote variant (DD), might contribute to the risk of COPD and COPD with PH among Asians. Further studies with larger sample size and more ethnicities are expected to be conducted in the future to validate the results.

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Section: Resultsmentioning

confidence: 99%

<em>ACE</em> gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

Ma¹,

Xiang²,

Liu³

et al. 2018

COPD

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“…Analysis of other published studies on whether ACE gene insertion/ deletion polymorphism was associated with the risk of chronic obstructive pulmonary disease suggests lack of significant association between I/D polymorphism and COPD. Carriers of II and ID genotypes had significantly lower levels of circulating angiotensin-converting enzyme than subjects with DD genotype 58 . A noteworthy detail is that an interaction between allele 894G of the gene encoding endothelial nitrogen oxide synthase and allele I of the ACE gene may reduce vasoconstriction and increase vasodilatation 61 , which is a positive effect in both COPD and hypertension.…”

Section: Discussionmentioning

confidence: 88%

“…Association between I/D polymorphism of the ACE gene and the risk for COPD is a very timely and widely studied issue; however, existing data need to be clarified and appended [55][56][57] . The low activity of ACE was recognized to play a positive role in the development of COPD 58 . It is worth noting that the DD genotype of ACE is generally associated with increased circulating and cellular levels of ACE and increased cardiovascular risk 59 .…”

Section: Discussionmentioning

confidence: 99%

The role of insertion-deletion polymorphism of the ACE gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease

Maksiv

Krynytska

Koval

2020

Bangladesh J Med Sci

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Objective. This study aims to establish the role of insertion-deletion polymorphism of the angiotensin-converting enzyme gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease. Materials and Methods: The study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Plasma ACE activity was determined photometrically by a commercially available kit. Results and Discussion: The distribution of polymorphic variants of the ACE gene among COPD-only patients genotype spreading was close to the data obtained in controls. In hypertensive patients, there were fewer ID heterozygotes and more ІІ homozygotes compared to controls. In the COPD+AH category of patients, II genotype was predominant in 7.1% subjects, DD genotype was predominant in 10.0% subjects and the proportion of ID heterozygotes was 17.1% lower compared to controls. The II genotype had a positive relationship with patient age and a negative relationship with body weights and respiratory rates of COPD+AH patients. The ID genotype was associated with increased respiratory rates; however, its correlation with the duration of the disease was negative. Conclusion: The data obtained in the study allow suggesting that polymorphism of the ACE gene doesn’t relate to development of AH in patients with COPD. The highest activity of ACE was found in patients with combination of COPD and AH; maximum findings of ACE activity were seen in patients with DD genotype. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.543-551

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“…The low activity of ACE was recognized to play a positive role in the development of COPD (28). It is worth noting that the DD genotype of ACE is generally associated with increased circulating and cellular levels of ACE and increased cardiovascular risk (29). However, most of overall ACE activity in the body is located in the pulmonary tissue, Fisher's exact p, two tailed (disease/control group) p = 1.0 p = 0.75 p = 0.75 -ACE, angiotensin-converting enzyme; COPD, chronic obstructive pulmonary disease; AH, arterial hypertension.…”

Section: Discussionmentioning

confidence: 99%

Comorbidities and medical course in a young patient diagnosed with severe obstructive sleep apnea

et al. 2019

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Background Cardiovascular diseases (CVDs) are common in people with chronic obstructive pulmonary disease (COPD), and their presence is associated with an increased risk for hospitalization, longer length of stay and all-cause and CVD-related mortality. We assessed the role of angiotensin-converting enzyme (ACE) gene polymorphism in the occurrence of arterial hypertension (AH) in patients with COPD. Methods The study group consisted of 96 patients. Group 1 had 25 individuals with COPD, Group 2 had 23 individuals with AH and Group 3 had 28 individuals with COPD and AH. The control group consisted of 20 healthy subjects. I/D genotypes of ACE were determined by polymerase chain reaction amplification. Results The frequency distribution of polymorphic genotypes of the gene encoding ACE and assessment of compliance with the Hardy-Weinberg population equilibrium were carried out in groups of patients with COPD, AH and COPD + AH combination. The frequencies of the genotype responsible for I/D polymorphism of the ACE gene in the control and experimental groups were not found to deviate significantly from the Hardy–Weinberg equilibrium. The results of the study have not demonstrated any significant impact of alleles of ACE genes or ACE genes on occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated that the presence of the D allele of the ACE gene may increase the risk for occurrence of the COPD + AH (OR = 1.26). Conclusion The data obtained in the study allow suggesting that the presence of D allele of the ACE gene may increase the risk for AH in patients with COPD.

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Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis

Cited by 9 publications

References 32 publications

<em>ACE</em> gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

<em>ACE</em> gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

The role of insertion-deletion polymorphism of the ACE gene in development of arterial hypertension in patients with chronic obstructive pulmonary disease

Comorbidities and medical course in a young patient diagnosed with severe obstructive sleep apnea

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