Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss

Bukreeva, Larisa; Grigorov, Alexandre; Kiesewetter, H.; Hoppe, Berthold

doi:10.1177/1470320309343813

Cited by 14 publications

(20 citation statements)

References 18 publications

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“…Our results are supported by the findings of Vettriselvi et al., Goodman et al., Al Sallout et al., Bagheri et al., and Aarabi et al., but our results are not supported by others (Fatini et al., Buchholz et al., Bukreeva et al., Corbo et al., Zhang et al., Ozdemir et al.) . An association between the ethnicity of the study population and the genetic contribution to the etiology of venous thromboembolism is possible, and ACE I/D has been found to be significantly associated with VTE, especially in African‐American populations .…”

Section: Discussionsupporting

confidence: 49%

“…The I/D polymorphism accounted for 47% of the phenotypic variance of serum ACE concentration, and the variant D/D genotype was associated with a high circulating ACE level; thus, the D allele of the ACE gene might be associated with increased levels of PAI‐1 . Given this, the ACE gene I/D polymorphism has also been investigated in connection with RPL, and these studies have yielded diverse results . Recently, three meta‐analyses reported a significant association between the ACE I/D polymorphism and idiopathic RPL .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study

Kim

Choi

Lee

et al. 2014

Am J Reprod Immunol

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study

Kim

Choi

Lee

et al. 2014

Am J Reprod Immunol

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“…There were some significant evidences showing that the RAS had taken part in the onset of some renal diseases [9], [10], [11], [12]. The level of plasma ACE, constitutively expressed in several types of somatic cells, is linked to an I/D polymorphism of 287 bp in intron 16 of the ACE gene [35], [36], [37]. D allele and DD homozygous have been reported to be associated with higher plasma ACE level [6], [16].…”

Section: Discussionmentioning

confidence: 99%

ACE I/D Gene Polymorphism Can't Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome: A Meta-Analysis

Zhou

Qin

et al. 2011

PLoS ONE

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BackgroundThe results from the published studies on the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and the treatment response to steroid in Asian children with idiopathic nephrotic syndrome (INS) is still conflicting. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and treatment response to steroid in Asian children and to explore whether ACE D allele or DD genotype could become a predictive marker for steroid responsiveness.Methodology/Principal FindingsAssociation studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of September 1, 2010, and eligible investigations were synthesized using meta-analysis method. Five investigations were identified for the analysis of association between ACE I/D gene polymorphism and steroid-resistant nephrotic syndrome (SRNS) risk in Asian children and seven studies were included to explore the relationship between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) susceptibility. Five investigations were recruited to explore the difference of ACE I/D gene distribution between SRNS and SSNS. There was no a markedly association between D allele or DD genotype and SRNS susceptibility or SSNS risk, and the gene distribution differences of ACE between SRNS and SSNS were not statistically significant. II genotype might play a positive role against SRNS onset but not for SSNS (OR = 0.51, P = 0.02; OR = 0.95, P = 0.85; respectively), however, the result for the association of II genotype with SRNS risk was not stable.Conclusions/SignificanceOur results indicate that D allele or DD homozygous can't become a significant genetic molecular marker to predict the treatment response to steroid in Asian children with INS.

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“…15 relevant studies were identified that described the association between the ACE I/D polymorphism and RPL. While reading the full texts, the following articles were removed: two studies did not meet Hardy-Weinberg equilibrium (P 0 0.0003 and P 0 0.0217, respectively) [25,26]; one study could not extract the allele data (ACE I/D in RPL) from its groups [27]; one study was not only focused on RPL, but also on pre-eclampsia and foetal growth restriction which made it hard to get the data required [28]; and the other two studies included the data of case and control groups, but little information about the ACE I/D polymorphism [16,29]. Finally, there were 9 studies meeting the inclusion criteria that were included [11,[30][31][32][33][34][35][36][37].…”

Section: Characteristicsmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2012

J Assist Reprod Genet

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Background Recurrent pregnancy loss (RPL) had said to be related to the angiotensin converting enzyme insertion/deletion polymorphisms (ACE I/D) gene polymorphisms. But the conclusions were controversial. This meta-analysis was conducted to investigate the real association in ACE I/D polymorphisms and RPL firstly. Methods Combine Pubmed Embase and HuGENet database in data analysis for this meta-analysis from October 2000 to November 2011. The metagen system was used to select the models and effects. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results 9 studies from six countries with 1264 RPL and 845 controls were included according to our criterion. Following the metagen system, we used the dominant model with random effects. The summary OR 01.61 (95% CI: 1.10-2.36, I 2 0 59.0%), which suggested the ACE D allele might increase the RPL risk in Asia (OR01.97, 95% CI: 1.31-2.98, I 2 0 44.4%), among Asians (OR01.69, 95% CI: 1.06-2.36, I 2 032.7%). In additional, after conducting sensitivity analysis, the results had no differences except for Caucasian subgroup reached to the significance (OR02.059, 95% CI: 1.455-2.914), so we couldn't ignore the relationship between the polymorphisms of ACE D/I gene and Caucasians yet. There seemed no publication bias in our eligible studies with Begg's test (P 0 0.867). Conclusions Results in this meta-analysis presented the positive function of the ACE I/D polymorphism in increasing the RPL risk. Furfure prospective studies were needed to confirm the precise relationship between the ACE I/D and RPL.

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Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss

Cited by 14 publications

References 18 publications

The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study

The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study

ACE I/D Gene Polymorphism Can't Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome: A Meta-Analysis

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

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