Association of annexin A5 polymorphisms with obesity

Seok, Ho-Sik; Lee, Byoung Wook; Kim, Jong Woo; Jung, Min Hyung; Lee, Seo Ra; Park, Ki Ho; Park, Young-Guk; Baik, Hee Jung; Chung, Joo‐Ho

doi:10.3892/br.2013.118

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…Whereas adipocytes of both fat depots had similar AnxA5 mRNA levels, stromal vascular cells in subcutaneous fat expressed less AnxA5 mRNA (Table 2). In line with other differentiation models, AnxA5 protein expression was induced in adipocytes during aging [35] and one study demonstrated an association of AnxA5 polymorphisms with obesity in a Korean patient cohort [78], which may suggest a function of AnxA5 directly or indirectly contributing to fat deposition, storage or mobilization.…”

Section: Annexin Expression Patterns In Adipose Tissue and Their Psupporting

confidence: 54%

Annexins in Adipose Tissue: Novel Players in Obesity

Grewal

Enrich

Rentero

et al. 2019

IJMS

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Obesity and the associated comorbidities are a growing health threat worldwide. Adipose tissue dysfunction, impaired adipokine activity, and inflammation are central to metabolic diseases related to obesity. In particular, the excess storage of lipids in adipose tissues disturbs cellular homeostasis. Amongst others, organelle function and cell signaling, often related to the altered composition of specialized membrane microdomains (lipid rafts), are affected. Within this context, the conserved family of annexins are well known to associate with membranes in a calcium (Ca2+)- and phospholipid-dependent manner in order to regulate membrane-related events, such as trafficking in endo- and exocytosis and membrane microdomain organization. These multiple activities of annexins are facilitated through their diverse interactions with a plethora of lipids and proteins, often in different cellular locations and with consequences for the activity of receptors, transporters, metabolic enzymes, and signaling complexes. While increasing evidence points at the function of annexins in lipid homeostasis and cell metabolism in various cells and organs, their role in adipose tissue, obesity and related metabolic diseases is still not well understood. Annexin A1 (AnxA1) is a potent pro-resolving mediator affecting the regulation of body weight and metabolic health. Relevant for glucose metabolism and fatty acid uptake in adipose tissue, several studies suggest AnxA2 to contribute to coordinate glucose transporter type 4 (GLUT4) translocation and to associate with the fatty acid transporter CD36. On the other hand, AnxA6 has been linked to the control of adipocyte lipolysis and adiponectin release. In addition, several other annexins are expressed in fat tissues, yet their roles in adipocytes are less well examined. The current review article summarizes studies on the expression of annexins in adipocytes and in obesity. Research efforts investigating the potential role of annexins in fat tissue relevant to health and metabolic disease are discussed.

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Section: Annexin Expression Patterns In Adipose Tissue and Their Psupporting

confidence: 54%

Annexins in Adipose Tissue: Novel Players in Obesity

Grewal

Enrich

Rentero

et al. 2019

IJMS

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“…Importantly, the current study revealed that Anxa2 was overexpressed in PA-induced IR, and the silencing of Anxa2 inhibited the NF-B signaling pathway. Interestingly, a previous study verified the important role of Anxa5 in obesity (51) while concluding that the silencing of Anxa1 may attenuate the development of obesity (21). Previously, Anxa2 has been speculated to potentially serve as an endogenous modulator of low-density lipoprotein receptor degradation (50).…”

Section: Discussionmentioning

confidence: 90%

Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway

Wang

Cheng

Yin

et al. 2019

American Journal of Physiology-Cell Physiology

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Insulin resistance (IR) continues to pose a major threat to public health due to its role in the pathogenesis of metabolic syndrome and its ever-increasing prevalence on a global scale. The aim of the current study was to investigate the efficacy of Anxa2 in obesity-induced IR through the mediation of the NF-κB signaling pathway. Microarray analysis was performed to screen differentially expressed genes associated with obesity. To verify whether Anxa2 was differentially expressed in IR triggered by obesity, IR mouse models were established in connection with a high-fat diet (HFD). In the mouse IR model, the role of differentially expressed Anxa2 in glycometabolism and IR was subsequently detected. To investigate the effect of Anxa2 on IR and its correlation with inflammation, a palmitic acid (PA)-induced IR cell model was established, with the relationship between Anxa2 and the NF-κB signaling pathway investigated accordingly. Anxa2 was determined to be highly expressed in IR. Silencing Anxa2 was shown to inhibit IR triggered by obesity. When Anxa2 was knocked down, elevated expression of phosphorylated insulin receptor substrate 1 (IRS1), IRS1 and peroxisome proliferator-activated receptor coactivator-1a, and glucose tolerance and insulin sensitivity along with 2-deoxy-d-glucose uptake was detected, whereas decreased expression of suppressor of cytokine signaling 3, IL-6, IL-1β, TNF-α, and p50 was observed. Taken together, the current study ultimately demonstrated that Anxa2 may be a novel drug strategy for IR disruption, indicating that Anxa2 gene silencing is capable of alleviating PA or HFD-induced IR and inflammation through its negative regulatory role in the process of p50 nuclear translocation of the NF-κB signaling pathway.

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“…Moreover, there is an association between inflammatory molecule levels and visceral obesity [37,38]. A recent study demonstrated that SNPs of ANXA5 are associated with susceptibility to being overweight or obese in Koreans [39]. Taken together, both ANXA1 and ANXA5 may play important roles in lipid metabolism and may be associated with obesity development in HFD-fed mice.…”

Section: Discussionmentioning

confidence: 99%

Differential Protein Expression in White Adipose Tissue from Obesity-Prone and Obesity-Resistant Mice in Response to High Fat Diet and Anti-Obesity Herbal Medicines

Kim

Park²,

Choi³

et al. 2015

Cell Physiol Biochem

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Background: One of the most interesting issues in obesity research is why certain humans are obesity-prone (OP) while others are obesity-resistant (OR) upon exposure to a high-calorie diet. However, the pathways responsible for these phenotypic differences are still largely unknown. Methods: In order to discover marker molecules determining susceptibility and/or resistance to obesity in response to high fat diet (HFD) or anti-obesity herbal medicine (TH), we conducted comparative proteomic analysis of white adipose tissue (WAT) from OP, OR, as well as TH-treated mice. Results: OP mice fed HFD gained approximately 33% more body weight than OR mice, and TH significantly reduced body weight gain in HFD-fed mice by 30%. These mice were further subjected to proteomic analysis using two-dimensional electrophoresis (2-DE) combined with matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). Proteomic data revealed 59 spots that were differentially regulated from a total of 1,045 matched spots, and 57 spots of these were identified as altered WAT proteins between OP and OR mice by peptide mass finger printing. Interestingly, 45 proteins were similarly regulated in OR mice in response to TH treatment. Of these, 10 proteins have already been recognized in the context of obesity; however, other proteins involved in obesity susceptibility or resistance were identified for the first time in the present study. Conclusion: Our results suggest that TH actively contributed to body weight reduction in HFD-fed obese mice by altering protein regulation in WAT, and it was also found that TH-responsive proteins can be used as potent molecules for obesity treatment.

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Association of annexin A5 polymorphisms with obesity

Cited by 11 publications

References 23 publications

Annexins in Adipose Tissue: Novel Players in Obesity

Annexins in Adipose Tissue: Novel Players in Obesity

Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway

Differential Protein Expression in White Adipose Tissue from Obesity-Prone and Obesity-Resistant Mice in Response to High Fat Diet and Anti-Obesity Herbal Medicines

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