Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery

Gelaye, Bizu; Sánchez, Sixto E.; Andrade, Ana Claudia; Gómez, Oswaldo; Coker, Ann L.; Dole, Nancy; Rondón, Marta B.; Williams, Michelle A.

doi:10.1016/j.jad.2019.11.006

Cited by 37 publications

(29 citation statements)

References 66 publications

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“…Furthermore, different from other studies in China (44,45), the association between antepartum depression and birth weight and birth weight z-scores in our study was not significant. Studies in other countries also suggested no evidence that antepartum depressive symptoms are associated with birth weight (15) or a higher odds of delivering a low-birth-weight infant (16), which was consistent with our conclusion.…”

Section: Discussionsupporting

confidence: 92%

“…In summary, according to existing studies, there is no general conclusion regarding the relationship between maternal depression and neonatal outcomes, (15,16,34) and this issue deserves further investigation. Because of the lack of attention in China, neither issue has been sufficiently studied.…”

Section: Introductionmentioning

confidence: 93%

“…Some studies have demonstrated that depressed pregnant women may have a shorter birth duration (13), a greater risk of preterm birth, delayed fetal development, and a greater risk of low birth weight than non-depressed women (11,14). Also, some studies showed that depression in pregnant women is not associated with preterm birth, low birth weight, or developmental delay (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies

Wei

Zhang

et al. 2022

Front. Public Health

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Background and aimsMaternal depression before and after delivery has dramatically increased in China. Therefore, this study aimed to examine the association between antepartum and postpartum depression and neonatal outcomes.DesignA population-based retrospective cohort study.SettingChina.ParticipantsData were obtained from China Family Panel Studies (CFPS). Different mother-child/infant samples were included in this study. Mother in CFPS2012 and CFPS2016 were linked with 1–2-year-old children in CFPS2014 and CFPS2018, respectively. Besides, and mothers in CFPS2012, CFPS2016, and CFPS2018 were linked with 0–1-year-old infants in CFPS2012, CFPS2016, and CFPS2018, respectively.MethodsMaternal depression was measured using the Center for Epidemiologic Studies Depression Scale. The neonatal outcomes included duration of gestational days, preterm birth, birth weight, birth weight z-score, weight, weight z-score, illness in the past month, and hospitalization in the past year. Propensity score matching was used to balance maternal, family, and infant/child characteristics between the maternal depression and non-maternal depression groups.ResultsMultivariable regression analysis of matched samples estimated that antepartum depression was associated with a shorter duration of gestation by 3.99 days (95% confidence interval [CI] = −7.21, −0.78). The association between antepartum depression and preterm birth, birth weight and birth weight z-score were not statistically significant. Postpartum depression was associated with more episodes of illness in the last month by 0.23 times (95% CI = 0.11, 0.36) and a higher odd of hospitalization in the previous year (OR = 1.59, 95% CI = 1.15, 2.20). The association between postpartum depression and weight or the weight z-score was not significant.ConclusionMaternal depression appears to be associated with worse neonatal outcomes.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies

Wei

Zhang

et al. 2022

Front. Public Health

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“…In the study, we found that prenatal maternal stress not only increased plasma corticosterone, but also decreased the weight gain of offspring. It has also been discovered that the presence of generalized anxiety disorder during pregnancy increases the incidence of low birth weight infants ( Gelaye et al, 2020 ). Further, using multiple behavioral experiments, the results showed that prenatal maternal stress leaded to the decline of independent and inquiry behavior ability in new and different environment of open-field test, decreased responsiveness to rewards in sucrose preference test and the generation of despair in suspended tail test of offspring, betoken that the prenatally stressed offspring had emergence of emotional behavior damage.…”

Section: Discussionmentioning

confidence: 99%

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Zhao

Wang

Wen

et al. 2022

PeerJ

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Background Numerous studies have shown that exposure to prenatal maternal stress (PMS) is associated with various psychopathological outcomes of offspring. The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota-gut-brain axis) has been aconsensus; however, there is a lack of research on the involvement mechanism of gut microbiota in the regulation of the BDNF/CREB signaling pathway in the hippocampus of prenatally stressed offspring. Methods Pregnant rats were subjected to chronic unpredictable mild stress (CUMS) to establish the prenatal maternal stress model. The body weight was measured and the behavioral changes were recorded. Offspring were tested to determine emotional state using sucrose preference test (SPT), open-field test (OFT) and suspended tail test (STT). Gut microbiota was evaluated by sequencing the microbial 16S rRNA V3–V4 region, and the interactive analysis of bacterial community structure and diversity was carried out. The expression of hippocampal BDNF, TrkB and CREB mRNA and proteins were respectively measured using RT-PCR and Western blotting. Results Prenatal maternal stress increased maternal plasma corticosterone levels, slowed maternal weight gain and caused depression-like behaviors (all P < 0.05). In offspring, prenatal maternal stress increased plasma corticosterone levels (P < 0.05) and emotional behavior changes (depression-like state) were observed (P < 0.05). The species abundance, diversity and composition of the offspring’s gut microbiota changed after the maternal stress during pregnancy (P < 0.05). Compared with the control group’s offspring, the species abundance of Lactobacillaceae was dropped, while the abundance of the Muribaculaceae species abundance was risen. Concurrent, changes in the hippocampal structure of the offspring and decreases in expression of BDNF/CREB signaling were noted (P < 0.05). Conclusions Prenatal maternal stress leads to high corticosterone status and abnormal emotion behavior of offspring, which may be associated with the abnormal BDNF/CREB signaling in hippocampus of offspring caused by the change of gut microbiota composition.

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“…The 2019/2020 Australian bushfire crisis is known to have elicited stress among pregnant women with asthma (Asthma Australia, personal communication), and previous studies have associated prenatal stress with low birth weight and preterm birth [ 39 ], including a study linking in utero stress related to a natural disaster (Montreal Ice storm) with lowered birth weights [ 40 ]. Furthermore, low birth weight and preterm birth are known risk factors for asthma and respiratory illnesses in childhood.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

Murphy

Karmaus

Mattes

et al. 2021

IJERPH

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Due to climate change, bushfires are becoming a more frequent and more severe phenomenon which contributes to poor health effects associated with air pollution. In pregnancy, environmental exposures can have lifelong consequences for the fetus, but little is known about these consequences in the context of bushfire smoke exposure. In this review we summarise the current knowledge in this area, and propose a potential mechanism linking bushfire smoke exposure in utero to poor perinatal and respiratory outcomes in the offspring. Bushfire smoke exposure is associated with poor pregnancy outcomes including reduced birth weight and an increased risk of prematurity. Some publications have outlined the adverse health effects on young children, particularly in relation to emergency department presentations and hospital admissions for respiratory problems, but there are no studies in children who were exposed to bushfire smoke in utero. Prenatal stress is likely to occur as a result of catastrophic bushfire events, and stress is known to be associated with poor perinatal and respiratory outcomes. Changes to DNA methylation are potential epigenetic mechanisms linking both smoke particulate exposure and prenatal stress to poor childhood respiratory health outcomes. More research is needed in large pregnancy cohorts exposed to bushfire events to explore this further, and to design appropriate mitigation interventions, in this area of global public health importance.

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Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery

Cited by 37 publications

References 66 publications

Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies

Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?

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