Association of Antibiotic Resistance With Antibiotic Use for Epidermal Growth Factor Receptor Inhibitor–Related Papulopustular Eruption

Hirotsu, Kelsey E.; Dang, Timothy; Li, Shufeng; Neal, Joel W.; Pugliese, Silvina; Subramanian, Aruna; Kwong, Bernice Y.

doi:10.1001/jamadermatol.2019.0063

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…Life-threatening grade 4 rashes associated with severe superinfection warrant permanent discontinuation of targeted therapy, along with hospitalization, supportive care, and initiation of appropriate antibiotics and oral or intravenous corticosteroids (prednisone equivalent of 1–2 mg/kg/day). Of note, topical retinoids and benzoyl peroxide are generally avoided because they may be irritating (Burtness et al, 2009, Scope et al, 2007); however, with increasing reports of bacterial resistance in this setting, benzoyl peroxide or antiseptic washes should be considered (Hirostu et al, 2019). Steroid-sparing drugs, such as calcineurin inhibitors, may be used but are less effective (Burtness et al, 2009, Scope et al, 2009).…”

Section: Targeted Therapiesmentioning

confidence: 99%

Dermatologic conditions in women receiving systemic cancer therapy

Ferreira

Ramseier

Leventhal

2019

International Journal of Women's Dermatology

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As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman’s self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt cancer therapy and can therefore affect overall survival and treatment response. In this article, we review the dermatologic adverse effects from traditional chemotherapy, targeted therapy, immune checkpoint inhibitors, and endocrine therapy that disproportionately affect women. The timely diagnosis and management of these dermatologic conditions is crucial in the multidisciplinary care of women with cancer.

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Section: Targeted Therapiesmentioning

confidence: 99%

Dermatologic conditions in women receiving systemic cancer therapy

Ferreira

Ramseier

Leventhal

2019

International Journal of Women's Dermatology

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Inpatient Evaluation and Management of Generalized Pustular Dermatoses

Davis,

Spencer,

Elhage

et al. 2023

Curr Derm Rep

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Purpose of Review The purpose of this paper is to discuss the evaluation and management of the most encountered pustular dermatoses in the inpatient setting. Recent Findings Generalized pustular psoriasis (GPP), acute generalized exanthematous pustulosis (AGEP), and acneiform eruptions are three pustular dermatoses encountered in the inpatient setting. New insights into the pathophysiology of these diseases are guiding the investigation of novel treatments for pustular dermatoses. Summary Although cases of pustular dermatoses are often benign and self-limited, careful evaluation and management are indicated as severe cases may pose legitimate health risks and require systemic therapy. Biologic agents are playing a larger role in the management of pustular dermatoses such as GPP.

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