Association of anxiety-depressive disorders with irritable bowel syndrome among patients attending a rural family practice center: a comparative cross-sectional study

Abstract

BackgroundComorbidity of irritable bowel syndrome (IBS) and psychiatric disorders is common, and the prevalence of at least one psychiatric disorder has been reported as high as 80% among patients with IBS.AimsTo explore the association of anxiety-depressive disorders with IBS and its different subtypes, and to evaluate the associations of lifestyle habits, dietary habits and sleeping quality with IBS.MethodsA comparative cross-sectional study was conducted at the AL-Mahsama Family Practice Center, Ismailia, Egypt. It was carried out between October 2019 and October 2020. Participants were categorised into 175 patients with IBS, diagnosed using the Rome IV criteria, and 175 patients without IBS. A semistructured questionnaire was used to collect data on sociodemographic characteristics, lifestyle habits, dietary habits and sleep quality from both groups. The Hamilton Anxiety Rating Scale was used to assess anxiety symptoms, whereas the Beck Depression Inventory Second Edition was used to assess depression symptoms.ResultsThere was a high statistically significant difference between both groups with regard to age, education, occupation and socioeconomic status (SES), being a smoker, being physically inactive, having sleep disturbance and having irregular meals; being either obese or overweight was more reported in the IBS group. There was a high statistically significant difference in the rate of anxiety and depression between patients with and without IBS. Mild, moderate and severe anxiety were reported in 37.1%, 42.9% and 20.0% of patients with IBS while most (80.0%) of the patients without IBS reported mild anxiety. Regarding depression, mild, moderate and severe depression were reported in 60.0%, 14.3% and 25.7% of the patients with IBS while most (82.9%) of the non-IBS participants reported mild depression.ConclusionsThe study shows a significant association between anxiety-depressive disorders and IBS, but no significant associations between anxiety-depressive disorders and IBS subtypes.

TNF-α, IL-6 and hsCRP in patients with melancholic, atypical and anxious depression: an antibody array analysis related to somatic symptoms

“…Besides, it is known that CRP may be a manifestation of a broader metabolic syndrome, especially in patients who currently have multiple, significant disease symptoms. Patients with the anxious depression subtype tend to have more somatic comorbidities28 and a wider range of physiological stress responses,29 leading to more severe HPA axis activation and oxidative stress, which may be related to anxious depression 21. In addition, pain, like loneliness, is an uncomfortable physical and mental experience and is one of the most common physical symptoms of a depressive disorder, which has a proven relationship to CRP 30.…”

Effect of Visceral Mobilization on Abdomino-Phrenic Dyssynergia in Irritable Bowel Syndrome Patients

“…In this study, each patient has been thoroughly assessed pre-and post-intervention protocol application utilizing the following materials: girth measurement using the metric tape to assess changes in abdominal circumference with the distance around the abdomen near the belly was calculated [7] and psychiatric assessment using two scales. The Beck Depression Inventory (BDI) includes 21 questions on a 4-point scale ranging from 0 (no symptom) to 3 (severe symptoms), with scores indicating depression level as follow: 0-13 (minimal), 14-19 (mild), 20-28 (moderate), and 29-63 (severe) [8] . Scores of 20-39, 40-59, and 60-80 on the Spielberger State-Trait Anxiety Inventory's 40 items on a 4-point Likert-type scale (0-3) for each item indicate low, moderate, and high anxiety, respectively [9] .…”

Evolution and significance of the psychosomatic model in gastroenterology

“…From the publication of the first document on diagnostic criteria for IBS in 1989 to the publication of Rome Ⅳ in 2016, 9 it has been clear that psychosocial aspects are widely involved in the development of FGID. 37 At the same time, it has also been suggested that psychological interventions, tricyclic antidepressants and selective serotonin reuptake inhibitors can be added to the treatment strategies of FGID, according to the condition of the patient, and making an active psychiatric referral when needed has been seen as a wise clinical principle. 15 IBD-IBS have been mentioned in cases within the Rome Ⅳ Multidimensional Clinical Profile for Functional Gastrointestinal Disorders.…”