Association of Apa I polymorphism of vitamin d receptor gene with type 2 diabetes mellitus in Saudi population

Iyer, Archana; New, Susan Lanham; Khoja, Sawsan; Al-Ghamdi, Maryam A.; Bahlas, Sami

doi:10.18006/2017.5(2).271.276

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…DM is a group of metabolic disorders which is characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. Although many studies have been carried out on the VDR gene and its association with various types of diabetes, the results seem to be highly population dependent (Iyer et al, 2017). Our study has clearly shown that the recessive t allele at TaqI site is associated with the prognosis of GDM.…”

Section: Discussionmentioning

confidence: 61%

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

Iyer¹,

New²,

Khoja³

et al. 2017

JEBAS

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Vitamin D is primarily associated with a major role in bone formation. It is also associated with onset and progniosis of diseases such as diabetes, cancer and cardiovascular diseases. In Saudi Arabia, the prevalence of DM is one of the highest reported in the world. There is accumulating evidence suggesting an association between the DM and vit D deficiency. This study was proposed to establish a possible correlation between gestational diabetes mellitus (GDM) and the polymorphisms in the vitamin D receptor (VDR) gene at the sites namely TaqI, BsmI, and ApaI. Results of this study revealed that homozygous recessive genotype tt of the TaqI site with GDM. This study will help to establish the role of VDR gene in occurrence of various subsets of DM which is a major metabolic disorder in Saudi Arabia.

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Section: Discussionmentioning

confidence: 61%

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

Iyer¹,

New²,

Khoja³

et al. 2017

JEBAS

Self Cite

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“…Our results are consistent with those reported in other studies in several countries indicating that there is no significant association of this SNP with type I diabetes (Denise et al, 2009, Lemos et al, 2008). A recent study showed that the FokI polymorphism is a risk factor for insulin resistance and susceptibility to type 2 diabetes (Iyer et al, 2017). Several groups have reported that VDR - FokI polymorphism is associated with cancers and autoimmune diseases, although the mechanisms remain to be determined (Dankers et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Receptor Gene Polymorphisms With the Evolution of MODY Diabetes: Study in Tunisian Patients

Guesmi

Zouaoui

Haouat

et al. 2021

Biological Research For Nursing

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Vitamin D (VD) cannot be considered as a true vitamin, but rather as a hormone, which exerts its action via a vitamin D receptor (VDR). Many genes have been shown to be involved in the evolution of diabetes in various populations, such as the vitamin D receptor gene. The aim of our study was to investigate if BsmI, TaqI, ApaI, FokI, and Tru9I, polymorphisms of VDR gene have an impact on MODY diabetes and its clinical aspects in a Tunisian population. A total of 95 patients and 153 controls were genotyped using PCR-RFLP. The comparison of the allelic and genotypic frequencies of the five polymorphisms between MODY subjects and control groups revealed the association of MODY diabetes with TaqI, Tru9I and BsmI polymorphisms and no significant differences were observed in the distributions for the ApaI and FokI polymorphisms. After stratification with biochemical and clinical parameters and TaqI, Tru9I and BsmI polymorphisms, we found an association between the three SNPs and different parameters such as age of diagnosis, therapy, hsCRP and HDL-C levels. Our results revealed that TaqI, Tru9I and BsmI polymorphisms may be more related to the progression of MODY diabetes. The possible role of vitamin D in the pathogenesis of MODY is far from being completely understood. Further knowledge on this issue may identify new candidate targets in the treatment and prevention of the disease. Our findings suggest that the TaqI, Tru9I and BsmI polymorphisms may be more related to the progression of MODY diabetes.

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“…The previous studies on the T2DM population in Jeddah, Saudi Arabia, showed the genotype and allele of the Apa-I Vitamin D receptor gene polymorphism as a risk factor for developing T2DM [8], but on the T2DM population in Turkey and Mexico showed the different results [9], [10]. Based on differences in the previous studies in various populations, this present study aims to analyze the role of the Apa-I Vitamin D receptor gene polymorphism in T2DM patients in the Universitas Sumatera Utara Hospital.…”

Section: Introductionmentioning

confidence: 99%

The Role of Apa-I Vitamin D Receptor Gene Polymorphism in Type 2 Diabetes Mellitus

Sari

Rusdiana

Daulay

2021

Open Access Maced J Med Sci

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome caused by insulin secretion abnormalities, insulin action, or both. Gene polymorphism is a risk factor of T2DM. AIM: This study aims to see the role of Apa-I Vitamin D receptor gene polymorphism on T2DM. METHODS: This study was an analytic observational with a case–control approach, consisting of 70 T2DM patients and 70 healthy subjects as a control. Genotyping of the Apa-I Vitamin D receptor gene polymorphism was performed using the polymerase chain reactions-restriction fragment length polymorphisms method. The role of the Apa-I Vitamin D receptor gene polymorphism and the risk of T2DM were analyzed using the Chi-square test. RESULTS: The results showed that there was a significant association between codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism with the risk of T2DM (p < 0.05; odds ratio [OR] = 0.204, 95% confidence interval [CI] = 0.063–0.662; OR = 0.337, 95% CI = 0.113–1.004; OR = 0.367, 95% CI = 0.180–0.747, respectively), but not in codominant (GT genotype) and over-dominant models (p > 0.05). CONCLUSION: This study shows a role of the codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism on T2DM, but not in codominant (GT genotype) and over-dominant models.

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Association of Apa I polymorphism of vitamin d receptor gene with type 2 diabetes mellitus in Saudi population

Cited by 6 publications

References 26 publications

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

Association of Vitamin D Receptor Gene Polymorphisms With the Evolution of MODY Diabetes: Study in Tunisian Patients

The Role of Apa-I Vitamin D Receptor Gene Polymorphism in Type 2 Diabetes Mellitus

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