Association of Apo B, Apo A1 and lipid Profile with Early Onset Stroke

Abstract

Background: Early onset of stroke is a devastating illness and dyslipidaemia are widely accepted risk factors for coronary heart disease (CHD). High Apolipoprotein B (Apo B), low Apolipoprotein A 1 (Apo A 1 ) and the Apo B/Apo A 1 ratio are used as the predictors of stroke for CHD. Objective: To evaluate the association of Apo B, Apo A 1 and lipid profile with early onset stroke. Methods: This case-control study was conducted in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka from Jan'2008 to Dec'2008. Total 100 stroke patients of both sexes were included, diagnosed by CT scan and MRI. Fifty stroke patients of early onset (EOS-P; age d"45 yrs) were included as case and 50 stroke patients of late onset (LOS-P; age >50 yrs) were taken as control. Serum lipid profile (TAG, TC, LDL-C & HDL-C), lipid ratios (TC/HDL-C, LDL-C/HDL-C & TAG/ TC), Apo B, Apo A 1 , and Apo B/Apo A 1 ratio were measured in all patients. Mann Whitney U test, Odds Ratio, unpaired t-test were used for statistical analysis. Results: In this study, serum Apo A 1, and TAG were significantly higher in EOS-P than those of LOS-P. Again, with respect of cut off value, odds ratio of 2.29 indicates that high serum Apo B concentration is associated whereas odds ratio of 0.38 indicates that low serum Apo A 1 concentration is not associated with EOS Conclusion: From this study it can be concluded that, higher level of TAG is a risk factors for early onset stroke and high Apo B is associated with early onset stroke.

The role of von Willebrand factor in determining the risk of ischemic stroke in Hawler city: a case-control study

“…This finding is in accordance with the other researchers. 19,20,21 However the mean fasting serum LDL-C level in patients with ischemic stroke was significantly higher (P<0.01) than healthy subjects. Similar results have been reported by other workers.…”

Apolipoprotein B - An ideal biomarker for atherosclerosis?

“…Levels of hs-CRP, apo-B, and TG/HDL ratio were not statistically significant in assessing the future CHD events. Malek R, 2015 16 Bangladesh Case-control study Stroke (early onset- age 45 years) To evaluate the association of Apo B, Apo A1 and lipid profile with early onset stroke Late onset stroke - Age >50 years 100 High Apo B concentration found with early onset stroke as compared to late onset stroke. Chowdhury AK, 2015 17 Bangladesh Case-control study Coronary heart disease, documented by coronary angiogram (CAG) To determine the blood levels of apolipoproteins in patients with coronary artery disease (CAD).…”