Association of Apolipoprotein B with Incident Type 2 Diabetes in an Aboriginal Canadian Population1

Ley, Sylvia H.; Harris, Stewart B.; Connelly, Philip W.; Mamakeesick, Mary; Gittelsohn, Joel; Wolever, Thomas M. S.; Hegele, Robert A.; Zinman, Bernard; Hanley, Anthony J.

doi:10.1373/clinchem.2009.136994

Cited by 60 publications

(51 citation statements)

References 15 publications

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“…The plasma concentration of APOB protein reflects the total number of potentially atherogenic particles 2,4 and, therefore, is predictive of high risk of coronary heart disease that may not be otherwise detected from routine lipid profile 2,[7][8][9][10] . High APOB protein level in blood is correlated with cerebrovascular and coronary artery diseases as well as increased risk of diabetes 1,3,11,12 . Variable number of tandem repeats (VNTRs), also known as minisatellites, comprise a significant portion (~3%) of the human genome 13 .…”

Section: Introductionmentioning

confidence: 99%

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Sajib

Khan

Haque

et al. 2018

Bangladesh J Med Sci

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Background: Apolipoprotein B (APOB) is a component of chylomicrons, low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and functions as the main protein for transporting cholesterol to peripheral cells. APOB gene has an AT-rich VNTR site at its 3ʹ-untranslated region (3ʹ-UTR). APOB 3ʹ-VNTR alleles with ≥36 repeats have been shown to be strongly associated with increased serum lipid levels, gallstone formation and coronary artery disease. Objectives: To investigate any possible association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure. Materials and methods: APOB 3ʹ-VNTR region in the DNA of non-diabetic controls and type 2 diabetic patients were amplified by polymerase chain reaction (PCR) and the numbers of core repeat in the amplified products were determined. Frequencies of the APOB alleles and genotypes among the controls and the patients were calculated and statistical analyses were performed. Results and discussion: Here we report for the first time that APOB 3ʹ-VNTR alleles have different distribution frequencies among type 2 diabetic and non-diabetic individuals. We also observed higher body mass index (BMI), systolic and diastolic blood pressures in individuals who had at least one APOB 3ʹ-VNTR allele with ≥35 repeats. Conclusion: Our study might bridge among the genetic signature of APOB 3ʹ-VNTR, high APOB protein level in blood, diabetes and other co-morbidities.

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Section: Introductionmentioning

confidence: 99%

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Sajib

Khan

Haque

et al. 2018

Bangladesh J Med Sci

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“…Instead, they reported that obesity and insulin resistance explained most of the association between leptin and subsequent diabetes risk. Other studies also suggest that abdominal adiposity may modulate the association between leptin and type 2 diabetes [9,12,14,15,25].…”

Section: Discussionmentioning

confidence: 99%

“…High levels of leptin have been shown to be independently associated with diabetes in some [8][9][10][11] but not all studies [7,[12][13][14][15]18]. Of these studies, only two were UK population based studies [7,10].…”

Section: Discussionmentioning

confidence: 99%

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The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Neville

Patterson

Linden

et al. 2016

Diabetes Research and Clinical Practice

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Woodside, J. V. (2016). The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. Diabetes Research and Clinical Practice, 120,[24][25][26][27][28][29][30] Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. Abstract:Aims: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.Methods: Baseline serum levels of leptin and adiponectin were measured in 1839 nondiabetic men aged 50-60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.Results: 151 participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95%CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95%CI 0.14-0.42) relative to men in the bottom third.However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin. Conclusions:This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

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“…[5] The association of ApoB with incident of T2DM has been demonstrated with improved risk prediction as compared to HDL cholesterol or LDL cholesterol. [27] Moreover, insulin resistance is strongly associated with Apo B/Apo A1 ratio. [28] While conventional lipid estimations have been stated to be related to the incident of T2DM, some dispute still prevails on the nature and the degree of association.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

Jamwal¹,

Yadav²,

Malik³

2018

AIMDR

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Background: Apolipoprotein A (Apo A) and apolipoprotein B (Apo B) are the key structural components of high density lipoprotein (HDL) particles and atherogenic lipoproteins respectively. The present study was designed to estimate and investigate the role of Apo A and Apo B levels along with standard lipid profile in patients with type 2 diabetes mellitus (T2DM). Methods: The study was carried out on 200 subjects viz. 100 healthy controls and 100 T2DM cases. Whole blood sample was utilized for glycosylated hemoglobin (HbA1c) and serum obtained was analyzed for quantitative estimation of total cholesterol, triglycerides, low density lipoprotein (LDL), HDL, Apo A and Apo B by automated chemistry analyzer. Results: A significant increase (p < 0.005) was observed in the mean HbA1c, cholesterol, triglycerides, LDL and Apo B levels in patients with T2DM as compared to healthy controls. On the contrary, a significant decrease (p < 0.005) was witnessed in the mean HDL and Apo A values of T2DM patients as compared to healthy controls. A positive correlation was seen between HbA1c and total cholesterol (r = 0.427); HbA1c and triglyceride levels (r = 0.281); HbA1c and LDL (r = 0.399); HbA1c and Apo B (r = 0.403). However, a negative correlation was observed between HbA1c and HDL (r = -0.337); HbA1c and Apo A (r = -0.426). Conclusion: There is a high prevalence of dyslipidemia with poorly controlled HbA1c in T2DM patients. Apo A and Apo B assays should be incorporated in the standard lipid profile, for better risk prediction in diabetics and to curtail the risk of future cardiovascular mortality.

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Association of Apolipoprotein B with Incident Type 2 Diabetes in an Aboriginal Canadian Population1

Cited by 60 publications

References 15 publications

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Apolipoprotein A and Apolipoprotein B Levels Along With Standard Lipid Profile in Type II Diabetes Mellitus Patients in a Tertiary Care Centre in Sub Himalayan Region

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