Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China

Abstract

BackgroundApolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.MethodsA total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.ResultsApolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p < 0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p < 0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.ConclusionsThis study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level.

Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR

“…Our co-expression analysis also indicates that HNF4A , is co-expressed with LINC01229 but not MAFTRR , consistent with the SUA2 LINC01229 eQTL and the coincidental expression of the SUA2 enhancer and hnf4a . LINC01229 and HNF4A also share enriched GO terms in lipid relevant pathways that involve genes with (albeit unreplicated) reports of association with urate (e.g., ApoE ) (Sun et al, 2015) and gout (e.g., ABCG1 and ABCA1 ) (Lai et al, 2012) (Supplementary Figure S14).…”

Sex‐dependent effects of uric acid on cerebral microbleed: a cross‐sectional study in the general population

“…There is a greater risk for CMB in male APOE4 carriers than in female APOE4 carriers . Moreover, APOE4 is associated with an increased risk for hyperuricemia in Chinese men . This suggests that different manifestations of CMB according to APOE4 carrier status may contribute to the observed sex differences.…”

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

“…The genetical background may have a potential influence in the prevalence of hyperuricemia among these different ethnic groups except lifestyle, a major factor. For example, previous studies reported that gene polymorphism in Uygur Chinese may be correlated with hyperuricemia such as ApoE E4, IL-8, IL-1RL1, IL-18 and SLC17A1 genes [48][49][50]. Hyperuricemia is a complicated metabolic disease with many risk factors.…”