Association of Arterial Stiffness and Osteoporosis in Healthy Men Undergoing Screening Medical Examination

Abstract

BackgroundAssociation of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD).MethodsWe reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray absorptiometry. Metabolic syndrome was based on the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25 kg/m2 was used instead of waist circumference.ResultsIn Pearson's correlation analysis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, total) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and women (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMD and PWV had an independent relationship in women after adjusting for age, metabolic syndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independent association was found between PWV and BMD in men.ConclusionsThe association between arterial stiffness and BMD was confirmed in women. However, this association was not statistically significant for men.

Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension

“…Recently, some reports found that BMD is not associated with baPWV in men . However, these studies were conducted in the general population.…”

“…The findings on the relationship between BMD and baPWV are inconsistent. Some reports demonstrate that BMD is associated with baPWV in patients with OP, whereas other studies reveal that the association is not significantly different . The discrepancies in these results may be attributed to small sample sizes, different sexes, and select populations.…”

“…Some reports demonstrate that BMD is associated with baPWV in patients with OP, whereas other studies reveal that the association is not significantly different. [8][9][10][11] The discrepancies in these results may be attributed to small sample sizes, different sexes, and select populations.The objective of this study was to investigate the relationship between BMD and baPWV in men with HTN.…”

Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

“…A significant inverse correlation between PWV and BMD was found in the general population in Macedonia [37]. A few studies performed in Japan and Korea have reported similar results in women [11, 34, 35]. However, other studies conducted in Japan and Korea have found no association between lumbar spine BMD and PWV in women [10, 22].…”

“…The association between BMD and baPWV has mainly been evaluated in women, and the conclusions drawn from studies are inconsistent and controversial [11, 34-37]. A significant inverse correlation between PWV and BMD was found in the general population in Macedonia [37].…”