Association of Arterial Stiffness With Markers of Vascular Endothelial Dysfunction and Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Kulik, Ekaterina; Pavlenko, Valentina; Нарышкина, С. В.

doi:10.12737/article_5a9f273cb8bdc0.80232446

Bulletin Physiology and Pathology of Respiration

2018

DOI: 10.12737/article_5a9f273cb8bdc0.80232446

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Association of Arterial Stiffness With Markers of Vascular Endothelial Dysfunction and Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Ekaterina Kulik¹,

Valentina Pavlenko²,

С. В. Нарышкина³

Abstract: Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской Федерации, 675000, г. Благовещенск, ул. Горького, 95 РЕЗЮМЕ С целью анализа взаимосвязей параметров ар-териальной ригидности (АР) с маркерами дисфунк-ции сосудистого эндотелия и системного воспаления, обследовано 69 больных ХОБЛ тяже-лого течения, высокого риска (GOLD 2013), в ста-дии обострения. Жесткость сосудистой стенки определяли с по… Show more

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Cited by 5 publications

References 8 publications

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Chronic Kidney Disease as a Manifestation of Comorbidity in Patients With Chronic Obstructive Pulmonary Disease

Bakina¹,

Pavlenko²

2018

Bulletin Physiology and Pathology of Respiration

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Chronic obstructive pulmonary disease (COPD) has many systemic effects, one of which is impaired renal function. Existing studies prove that patients with COPD often have risk factors for developing chronic kidney disease (CKD). Many risk factors for developing COPD are common for the onset of CKD. However, in routine clinical practice, there is an underestimation of the incidence of renal dysfunction in COPD patients, while in-depth and targeted studies reveal changes in renal function in patients with COPD. Topical methods for identifying initial changes in renal function in COPD patients are the study of the glomerular filtration rate, the evaluation of the level of microalbuminuria, the study of the index of resistance of renal vessels. The importance of identifying CKD in the early stages in COPD patients is determined by the increased risk of cardiovascular events and the onset of cardiorenal syndrome in patients.

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Chronic Kidney Disease as a Manifestation of Comorbidity in Patients With Chronic Obstructive Pulmonary Disease

Bakina¹,

Pavlenko²

2018

Bulletin Physiology and Pathology of Respiration

Self Cite

View full text Add to dashboard Cite

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Arterial stiffness and albuminuria as markers of endothelial dysfunction in those with chronic obstructive pulmonary disease

Bakina

Pavlenko

Нарышкина

2021

Tuberk. bolezni lëgk.

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The objective: to assess the state of arterial stiffness and the level of albuminuria in patients with chronic obstructive pulmonary disease (COPD) and to investigate the presence and nature of the association of the studied parameters with clinical and laboratory parameters of COPD.Subjects and methods. 70 patients with COPD were examined, they all were divided into 4 groups depending on severity of clinical symptoms and number of exacerbations suffered in the previous 12 months. Additionally to standard examinations, albuminuria level, the pulse wave velocity in aorta (PWVa), and cardio-ankle vascular index (CAVI) were assessed.Results. The increased albuminuria level was registered in 51.4% of patients mainly suffering from frequent exacerbations. The increased CAVI and PWVa also prevailed in individuals with a high frequency of exacerbation and their higher levels were found in 37.1% and 14.3% of patients, respectively. PWVa and CAVI values were found to be associated with albuminuria level and clinical and laboratory parameters of COPD.

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Endotheliopathy and systemic inflammation: reversibility of cause-and-effect relationship in the pathological functional system (review of literature)

Сазонова

Zhmerenetsky

Zhivotova

et al. 2022

Regional blood circulation and microcirculation

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The review considers the involvement of the endothelium and endothelial glycocalyx in the systemic inflammatory response. The role of the endothelium in the inflammation is ambivalent and depends on the nature of the inflammatory process. The physiological response of endothelial cells to local inflammation is necessary to successful eliminate the pathogen and restore the tissue homeostasis. In systemic inflammation, the endothelium is the most «suffering» structure of the body. However, endothelial cells can be a source of systemic inflammatory mediators, supporting the pathological inflammatory process. The problem of generalization of inflammation is discussed where endotheliopathy develops and closes the vicious circle, being both a consequence of systemic inflammation and the cause of its prolongation and intensification. In the pathogenesis of a new coronavirus infection the relationship between endotheliopathy and systemic inflammation was most clearly manifested. Preceding endothelial dysfunction causes a severe course of COVID-19 with a «cytokine storm» and coagulopathy that can lead to the death. SARS-CoV-2 infection induces long-term endothelial dysfunction, which is recorded even after the virus elimination. The early detection of blood level of endothelial glycocalyx damage markers (i. e. syndecan-1, glycosaminoglycans like heparan sulfate and hyaluronic acid) may seem to be an effective approach to the prevention of severe forms of COVID-19. Endothelial-protective drugs can reduce the risk of severe new coronavirus infection and eliminate the manifestations of long-COVID.

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Association of Arterial Stiffness With Markers of Vascular Endothelial Dysfunction and Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Cited by 5 publications

References 8 publications

Chronic Kidney Disease as a Manifestation of Comorbidity in Patients With Chronic Obstructive Pulmonary Disease

Chronic Kidney Disease as a Manifestation of Comorbidity in Patients With Chronic Obstructive Pulmonary Disease

Arterial stiffness and albuminuria as markers of endothelial dysfunction in those with chronic obstructive pulmonary disease

Endotheliopathy and systemic inflammation: reversibility of cause-and-effect relationship in the pathological functional system (review of literature)

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