Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population

Seok, Ho-Sik; Kim, Su Kang; Yoo, Kyung Ho; Lee, Byung-Cheol; Kim, Young Ock; Chung, Joo‐Ho

doi:10.12965/jer.140168

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…The pooled p value, OR, and 95% CI were used to investigate the association between the risk of COPD and ACE insertion/deletion polymorphism. In the present meta-analysis, we adopted the following genetic models [24, 25]: codominant 1 (I/D genotype versus I/I genotype), codominant 2 (D/D genotype versus I/I genotype), dominant (D/D genotype + I/D genotype versus I/I genotype), and recessive (D/D genotype versus I/D genotype + I/I genotype) models and the allele model (D allele versus I allele). For codominant 1, codominant 2, and dominant models, we used I/I genotype as the reference group.…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

Kang

Kim

Chung

et al. 2016

BioMed Research International

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The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between the ACE gene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooled p value, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD (p > 0.05 in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of the ACE gene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919–5.093, p < 0.001; recessive, OR = 3.326, 95% CI = 2.190–5.050, p < 0.001) but not in the Caucasian population (p > 0.05 in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of the ACE gene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.

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Section: Methodsmentioning

confidence: 99%

Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

Kang

Kim

Chung

et al. 2016

BioMed Research International

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“…For meta-analysis of TNF-a polymorphism (-308G/A), the pooled ORs, 95% CI, and p-value were calculated using combination of genotype. We first estimated the risk of the A/A genotype and A/G genotype for asthma compared with the G/G genotype as dominant model, respectively, and then evaluated the risk of ''A allele versus G allele,'' ''A/A genotype+A/G genotype versus G/G genotype,'' and ''A/A genotype versus A/G genotype+G/G genotype'' on risk of asthma, assuming dominant and recessive effects of the variant A allele, respectively (Seok et al, 2014;Park and Kim, 2015;Kang et al, 2016Kang et al, , 2017Kim et al, 2017b). The p < 0.05 was regarded as statistically significant association with asthma.…”

Section: Discussionmentioning

confidence: 99%

Promoter Polymorphism (−308G/A) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Asthma Risk: An Updated Meta-Analysis

Kang

Kim

Han

et al. 2019

Genetic Testing and Molecular Biomarkers

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Background and Aims: The relationship between the promoter polymorphism (-308G/A) of the tumor necrosis factor-alpha (TNF-a) gene and the susceptibility to asthma has been tested in several studies. However, the results have been inconsistent. Therefore, we performed an updated meta-analysis to evaluate the relationship between this promoter polymorphism of the TNF-a gene and the risk of asthma. Methods: Fifty case-control studies were included in this meta-analysis which provided 17,937 controls and 9961 asthma patients. The pooled p-value, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association of this polymorphism of the TNF-a gene with the risk of asthma. The meta-analysis was carried out by Comprehensive Meta-Analysis software. Results: The results of our meta-analysis revealed that the TNF-a polymorphism (-308, G/A) was strongly associated with the risk of asthma (p < 0.05 in the allelic, dominant, and recessive models, respectively). In further analyses, based on age group and ethnicity, we observed this association for all subpopulations examined (p < 0.05 in allelic, dominant, and recessive models, respectively). Conclusion: This large-scale meta-analysis supports a strong association between the TNF-a gene promoter polymorphism (-308G/A) and the development to asthma in both children and adults.

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“…Genotype models (codominant, dominant, recessive, and log-additive) and logistic regression analysis were applied to determine whether differences in genotype frequencies between the periodontal disease and control groups were significant (Kim et al, 2013;Seok et al, 2014). SNPStats and SPSS 18.0 (SPSS, Inc., Chicago, IL, USA) were used for the statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of CASP gene polymorphisms in periodontal disease

Sw¹,

Kim²,

Chung³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in the development of periodontal disease, 51 patients and 33 control subjects were assessed. A total of 201 CASP gene SNPs were analyzed with genotypes being determined using and Axiom™ genomewide human assay. SNPStats and SPSS 18.0 were used for the analysis of genetic data and logistic regression models were utilized to evaluate odds ratios, 95% confidence intervals, and P values. Of the 201 SNPs, only three (rs12108497, rs4647602, and rs113420705, all in the CASP3 gene) were significantly associated with chronic periodontitis (P < 0.05). The minor allele frequencies of these SNPs were higher in the patient group than in the control group. In addition, the TC and GT haplotypes 18070 S.W. Kang et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18069-18077 (2015) formed by rs4647602 and rs113420705 were found to be associated with chronic this disease (TC haplotype, P = 0.0039; GT haplotype, P = 0.002). These results suggest that CASP3 gene polymorphisms may be associated with susceptibility to periodontal disease in the Korean population.

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Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population

Cited by 8 publications

References 34 publications

Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

Promoter Polymorphism (−308G/A) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Asthma Risk: An Updated Meta-Analysis

Assessment of CASP gene polymorphisms in periodontal disease

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