Association of Birth Parameters with OCT Measured Macular and Retinal Nerve Fiber Layer Thickness

Tariq, Yasser M.; Pai, Amy; Li, Haitao; Afsari, Sonia; Gole, Glen A.; Burlutsky, George; Mitchell, Paul

doi:10.1167/iovs.10-6365

Cited by 56 publications

(68 citation statements)

References 31 publications

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“…This result is in agreement with recent studies using SD-OCT. 1,2,7 With regard to sectoral distributions of peripapillary RNFL, it has been reported that peripapillary RNFL thickness on the temporal side of the disc is thicker in preterm children than in full-term controls, whereas all other peripapillary RNFL sectors are thinner in preterm children than those in full-term children. 1,2 In this study, the results also showed that all peripapillary RNFL sectors except for the temporal side were thinner in preterm children than those in full-term controls. Statistically significant differences were observed in the average total, nasal, and superior disc RNFL thicknesses after adjustment for patients' age at examination and spherical equivalent refractive error.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies using optical coherence tomography (OCT) have revealed that preterm children also have a thinner peripapillary retinal nerve fiber layer (RNFL) than children born at term, suggesting an association between prematurity and subclinical optic nerve hypoplasia. 1,2 These studies showed a significant correlation between RNFL thickness and gestational age 1 and birth weight. 2 Because gestational age and birth weight are closely related with each other and are also strongly correlated with development of other disorders including retinal vascular disorder, ROP, it is difficult to determine which factor is a critical contributor for the abnormality in the optic nerve development in prematurity.…”

Section: Introductionmentioning

confidence: 94%

“…1,2 These studies showed a significant correlation between RNFL thickness and gestational age 1 and birth weight. 2 Because gestational age and birth weight are closely related with each other and are also strongly correlated with development of other disorders including retinal vascular disorder, ROP, it is difficult to determine which factor is a critical contributor for the abnormality in the optic nerve development in prematurity. Åkerblom et al 3 recently attempted to determine the most critical factor involved in the abnormality of RNFL thickness and reported that ROP stage is inversely correlated with RNFL thickness.…”

Section: Introductionmentioning

confidence: 94%

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Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

2015

Eye

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Purpose To compare retinal nerve fiber layer (RNFL) thickness profiles between preterm and full-term children and to investigate factors affecting the RNFL distribution in preterm children.Methods We performed Spectral domain optical coherence tomography (SD-OCT) peripapillary RNFL circular scan centered on the optic disc in 50 premature and 58 full-term children. RNFL thickness profiles were compared between preterm and fullterm children using a linear regression model. Among preterm patients in this study, 20 patients previously received laser treatment for severe retinopathy of prematurity (ROP).Results Global average, nasal, and superior disc RNFL thickness profiles were significantly smaller in preterm children (92.70 ± 16.57 μm, 56.02 ± 17.04 μm, and 108.74 ± 27.36 μm, respectively) compared with full-term children (101.63 ± 9.21 μm, P = 0.006, 69.14 ± 14.15 μm, Po0.001, and superior, 129.11 ± 18.14 μm, Po0.001, respectively). Multivariable analysis revealed that ROP stage was inversely correlated with nasal RNFL thickness (P = 0.010).Conclusions Our SD-OCT data demonstrate decreased global average, nasal, and superior disc RNFL thicknesses in preterm children. ROP stage was inversely correlated with nasal RNFL thickness. Further studies are needed to better understand the association between these structural changes and visual functions in preterm children.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 94%

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Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

2015

Eye

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“…It has been shown that both low birth weight and prematurity have important and significant effects on posterior segment structures, e.g., fovea, macula, retinal nerve fiber layer (RNFL), and optic disc. 22,23 In the study, we examined the association between birth weight and anterior segment structures. Our study population comprised preschool children, born at term, with birth weight of >2500 g. Previous studies had reported that prematurity and low birth weight have significant effects on the anterior segment, particularly in premature infants with/without ROP (Retinopathy of Prematurity).…”

Section: Discussionmentioning

confidence: 99%

“…Decreased birth weight is also associated with decreased retinal nerve fiber layer thickness. 22 These findings suggest that low birth weight may impair retinal nerve fiber layer and corneal development, and may predispose such children to ocular problems, e.g., glaucoma or keratoconus, in later life. Central part of the cornea is the most important area for biomechanics and optics of corneal architecture.…”

Section: Accepted Manuscriptmentioning

confidence: 93%

Effects of Birth Weight on Anterior Segment Measurements in Full-Term Children Without Low Birth Weight by Dual-Scheimpflug Analyzer

Yeter

Arıtürk

Birinci

et al. 2015

American Journal of Ophthalmology

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Association of Maternal Smoking During Pregnancy and Birth Weight With Retinal Nerve Fiber Layer Thickness in Children Aged 11 or 12 Years

Ashina

Olsen

et al. 2017

JAMA Ophthalmol

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IMPORTANCE Both maternal smoking during pregnancy and low birth weight have been implicated in impaired development of the retina. OBJECTIVE To investigate the associations of maternal smoking during pregnancy and low birth weight with retinal nerve fiber layer (RNFL) thickness in preadolescent children. DESIGN, SETTING, PARTICIPANTS The Copenhagen Child Cohort 2000 Eye Study is a prospective, population-based, birth cohort study that included all children (n = 6090) born in 2000 in Copenhagen, Denmark. Maternal smoking data were collected through parental interviews. Birth weight, pregnancy, and medical history data were obtained from the Danish Medical Birth Registry. As a follow-up, the study performed eye examinations on 1406 of these children from May 1, 2011, to October 31, 2012, when the children were aged 11 or 12 years. The participants were predominantly (1296 [92.4%]) of European descent. Study data were analyzed from June 1, 2016, to October 1, 2016. MAIN OUTCOMES AND MEASURES Peripapillary RNFL thickness measured using optical coherence tomography at the 11-or 12-year examination. RESULTS Of the 1406 children in the study, 1323 were included in the analysis (mean [SD] age was 11.7 [0.4] years; 633 [47.8%] were boys and 690 [52.2%] were girls). The mean (SD) RNFL thickness was 104 (9.6) μm. In 227 children whose mothers had smoked during pregnancy, the peripapillary RNFL was 5.7 μm (95% CI, 4.3-7.1 μm; P < .001) thinner than in children whose mothers had not smoked after correction for age, sex, birth weight, height, body weight, Tanner stage of pubertal development, axial length, and spherical equivalent refractive error. In low-birth-weight children (<2500 g), the RNFL was 3.5 μm (95% CI, 0.6-6.3 μm; P = .02) thinner than in normal-birth-weight children after adjustment for all variables. CONCLUSIONS AND RELEVANCE Exposure to maternal smoking during uterine life and low birth weight were independently associated with having a thinner RNFL at age 11 or 12 years. These observations support previous findings that intrauterine and perinatal factors can have long-lasting effects on the retina and the optic nerve. The results of this study add evidence to existing recommendations to avoid smoking during pregnancy and support measures that promote maternal and fetal health.

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Association of Birth Parameters with OCT Measured Macular and Retinal Nerve Fiber Layer Thickness

Cited by 56 publications

References 31 publications

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

Effects of Birth Weight on Anterior Segment Measurements in Full-Term Children Without Low Birth Weight by Dual-Scheimpflug Analyzer

Association of Maternal Smoking During Pregnancy and Birth Weight With Retinal Nerve Fiber Layer Thickness in Children Aged 11 or 12 Years

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