Association of blood glucose and lipid levels with complete blood count indices to establish a regression model

Abstract

Abstract. Hyperglycemia and hyperlipidemia, which are usually diagnosed by analysis of blood glucose (GLU) and lipid levels, are two of the most common diseases in modern society. The purpose of the current study was to investigate the potential association between blood GLU and lipid levels with complete blood count (CBC) indices in overweight and healthy individuals and establish a regression model. There were 456 healthy and 421 overweight participants in the study. Data were collected on triglyceride (TG), total cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood GLU and CBC. The distribution characteristics and differences between healthy and overweight subjects were analyzed. Subsequently, the associations between TG, CHO, HDL, LDL and GLU with CBC were analyzed using correlation analysis and multiple linear regression (MLR). Significant differences were identified between the healthy and overweight individuals in TG, CHO, HDL, LDL, GLU and in the majority of the CBC indices. The correlation analysis indicated that there were strong correlations between TG, LDL, HDL, CHO and GLU with CBC indices in the healthy and overweight subjects. The MLR demonstrated that the regression models of TG, LDL, HDL and CHO, but no GLU, were statistically significant in the two groups (P<0.001). The HDL regression model exhibited the best regression parameters; the multiple correlation coefficients (R) were 0.351 and 0.308 in the healthy and overweight subjects, respectively. In the overweight and healthy subjects, there were strong correlations between TG, LDL, HDL and CHO with CBC indices, with HDL being the most relevant to the CBC indices. The CBC demonstrated statistical significance in the diagnosis of hyperlipidemia.

Características sociodemográficas y clínicas relacionadas con la condición final de pacientes intoxicados por paraquat en un hospital del suroccidente de Colombia

“…A propósito de la mortalidad de pacientes intoxicados con paraquat, en el análisis ajustado de esta investigación se encontró que la muerte se relacionaba con características como tiempo de hospitalización, frecuencia cardiaca y creatinina en el momento del ingreso. Estudios en otras regiones indican como predictores de mal pronóstico a la cantidad ingerida, un nivel alto de creatinina, hiperamilasemia, hiperglucemia, niveles elevados de lactato y compromiso multiorgánico (26)(27)(28)(29)(30)43,44). Lee, et al, afirman, en detalle, que el 23,75 % de los pacientes fallecen después de la intoxicación por paraquat al referir factores como la cantidad ingerida, las condiciones clínicas y la alteración de los parámetros de laboratorio, entre otros (45).…”

“…Actualmente, no se cuenta con un antídoto específico que realmente repercuta en el pronóstico del paciente. Otros factores asociados con la intoxicación por paraquat, descritos como predictores de mal pronóstico, son cantidad ingerida, valor sérico de la creatinina, hiperamilasemia, hiperglucemia y compromiso multiorgánico (26)(27)(28)(29)(30).…”

Ethyl acetate extract of crabapple fruit is the cholesterol-lowering fraction

“…Blood glucose homeostasis is closely related to lipid metabolism. 32,33 To investigate EAC effect on glucose and lipid balance, fasting blood glucose and short-term effects of EAC on the blood glucose levels of the DIO mice were tested. As expected, high-fat diet induced higher fasting blood glucose levels and impaired glucose tolerance, compared to the chow control mice (Fig.…”

Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction

“…For example, the excessive production of ATP by creatine kinase is the pathogenesis of angiocardiopathy [ 1 ] and the aberrant concentration of ATP will cause energy disturbance, resulting in hypoglycaemia, ischemia, and Parkinsons’ disease [ 2 ]. On the other hand, the high glucose levels will produce diabetes mellitus, which damages the eyes, kidneys, feet, and heart, and also causes a series of angiocardiopathy [ 3 ], while hypoglycaemia is usually due to the low concentration of glucose. This means that both the levels of ATP and glucose are related to angiocardiopathy and hypoglycaemia by virtue of the coexistence of ATP and glucose in biological samples [ 4 , 5 , 6 , 7 ], thus, the simultaneous determination of ATP and glucose with a single test mode is highly desirable for disease diagnostics and early recognition.…”