Association of bone mineral density and mammographic breast density in premenopausal and postmenopausal Malaysian women: Study on women with and without breast cancer

Zain, Norhayati Mohd; Seriramulu, Vengkatha Priya; Chelliah, Kanaga Kumari; Soin, Norhayati; Arasaratnam, Shantini

doi:10.1109/biosmart.2016.7835595

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…Consequently, although numerous studies have been conducted to clarify this issue, there are no conclusive results. A systemic review has also found that the association between BMD and breast cancer risk is still debatable [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?

Lee¹,

Kim²,

Jung³

et al. 2023

Korean J Clin Oncol

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Purpose: Several studies are concerned about the association between bone mineral density (BMD) and the risk of breast cancer in postmenopausal women, but it is controversial. Therefore, we evaluated whether BMD might be a risk factor for recurrences, or metastases in menopausal luminal A breast cancer patients.Methods: In this retrospective study, data of 348 patients with luminal A breast cancer who received treatment at Pusan National University Yangsan Hospital between 2012 and 2016 were analyzed. Patients were divided into two groups: normal BMD and low BMD including osteopenia or osteoporosis in preoperative examination. Patients were also divided into three groups according to BMD changes: no change in BMD; improvement in BMD, and deterioration in BMD. Events were defined as recurrence, occurrence of contralateral breast cancer, and metastasis to any other organ.Results: Preoperative examination revealed normal BMD in 129 of 348 patients and low BMD in 219 patients. During a median follow-up period of 78 months, only 14 patients (4.0%) experienced recurrences, distant metastases, or occurrences of contralateral breast cancer. Five-year disease-free survival rate was 98.2% for 219 patients with low BMD and 95.0% for 129 patients with normal BMD (P=0.33). Disease-free survival at 5 years was 97.0% for the no change in the BMD group, 94.6% for the BMD improvement group, and 98.4% for the BMD deterioration group (P=0.79).Conclusion: In this study, BMD had no statistically significant associations on recurrences, metastases, or incidences of contralateral breast cancer in postmenopausal patients with luminal A breast cancer.

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Section: Discussionmentioning

confidence: 99%

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?

Lee¹,

Kim²,

Jung³

et al. 2023

Korean J Clin Oncol

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“…There is substantial inconsistency among different studies in results regarding the connection between anthropometry and BMD and breast cancer risk. Furthermore, this association tends to vary depending on certain population characteristics such as ethnicity and menopausal status [ 9 , 10 ]. Thus, to capture the most sensitive estimation of risk factor association, research effort needs to stratify analyses based on these characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…Bone mineral density is considered as a crucial parameter used to evaluate the bone quality and to identify people with osteoporosis, a disease that commonly strikes women, particularly after menopause due to greater bone loss caused by lower levels of estrogen [ 10 , 28 ]. Notably, high BMD is a lifetime marker of continued exposure to estrogen, which controls the turnover of bones through suppressing bone resorption and activating specific hormones that stimulate the formation of bones [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several factors are proved to be commonly linked with an elevated breast cancer risk in women such as factors related to genetics, menstruation, reproduction, exogenous hormone intake, and nutrition [ 8 ]. Nevertheless, there are emerging factors thought to contribute to breast cancer risk, such as anthropometry and bone mineral density (BMD) [ 9 , 10 ]. Prior research suggested a possible link between breast cancer risk and anthropometric measurements such as body mass index (BMI).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have shown that high BMD might be associated with higher breast cancer risk, mainly in postmenopausal females due to long-term estrogen exposure. However, this relationship is still inconclusive and needs further investigation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Anthropometry, bone mineral density and risk of breast cancer in premenopausal and postmenopausal Saudi women

et al. 2020

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Introduction: Anthropometry and bone mineral density are linked to hormonal imbalance, which plays a possible role in breast carcinogenesis. The current study was designed to explore the relationship between selected anthropometric and bone mineral density parameters and the risk of breast cancer in premenopausal and postmenopausal Saudi women. Material and methods: A cross-sectional study was carried out among premenopausal (n = 308) and postmenopausal (n = 148) women at two Medical Cities in Riyadh, Saudi Arabia from May 2015 to June 2016. Selected anthropometric measurements were obtained from 456 women; 213 of them had breast cancer. Bone mineral density was also measured using dual-energy X-ray absorptiometry. Results: Greater waist circumference was significantly correlated with a higher breast cancer risk in premenopausal women (OR = 1.02, p = 0.03) but not in postmenopausal women. Greater triceps skinfold thickness had been found to be significantly correlated with a higher risk of breast cancer in premenopausal (OR = 1.06, p = 0.001) and postmenopausal (OR = 1.06, p = 0.001) women. However, bone mineral density was not significantly associated with breast cancer risk in either group of participants. Conclusions: Breast cancer risk was significantly associated with waist circumference and triceps skinfold thickness in premenopausal women and with only triceps skinfold thickness in postmenopausal women.

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Is There a Relationship Between Bone Mineral Density, Mammographic Breast Density and Serum Estrogen Concentration Level? Study on Malaysian Women

et al. 2017

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Association of bone mineral density and mammographic breast density in premenopausal and postmenopausal Malaysian women: Study on women with and without breast cancer

Cited by 3 publications

References 15 publications

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?

Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?

Anthropometry, bone mineral density and risk of breast cancer in premenopausal and postmenopausal Saudi women

Is There a Relationship Between Bone Mineral Density, Mammographic Breast Density and Serum Estrogen Concentration Level? Study on Malaysian Women

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